Article
Cell & Tissue Engineering
Takeshi Tada, Hiroe Ohnishi, Norio Yamamoto, Fumihiko Kuwata, Yasuyuki Hayashi, Hideaki Okuyama, Tsunetaro Morino, Yoshiyuki Kasai, Hiromi Kojima, Koichi Omori
Summary: This study transplanted hiPSC-derived AECs into the middle ear of immunodeficient rats and found the presence of HNA-positive ciliated cells after transplantation. The percentage of HNA-positive ciliated cells in the transplanted areas increased in the 2-week postoperative group compared with the 1-week group, indicating the survival of hiPSC-derived AECs. Immunohistochemical analysis showed the presence of basal cells and goblet cells in the transplanted AECs, suggesting the regeneration of these cell types within the middle ear cavity.
REGENERATIVE THERAPY
(2022)
Article
Virology
Bengul Durmaz, Olkar Abdulmajed, Riza Durmaz, Mehmet Koroglu, Oguz Ari, Serdal Celik, Mahmut Tayyar Kalcioglu
Summary: The study found that at least one respiratory virus was detected in 56% of children with otitis media with effusion, compared to 12.8% in individuals without middle ear disease. There was no positive association between viruses and bacteria found in the middle ear cavity. The detection rate of respiratory viruses was significantly higher in children aged 6 to 11 years.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, Research & Experimental
Mana Espahbodi, Tina L. Samuels, Caroline McCormick, Pawjai Khampang, Ke Yan, Samuel Marshall, Michael E. McCormick, Robert H. Chun, Steven A. Harvey, David R. Friedland, Nikki Johnston, Joseph E. Kerschner
Summary: Cell culture models are valuable for investigating the molecular pathogenesis of otitis media (OM), showing that pediatric MEE cells differ significantly from adult-derived HMEEC-1 cells in response to inflammatory stimuli and expression of OM-related molecules. OM may be associated with specific molecular phenotypes that are retained in primary cell culture.
Article
Pharmacology & Pharmacy
Manar Magdy, Enas Elmowafy, Mona Elassal, Rania A. H. Ishak
Summary: This review focuses on the anatomy of the ear, barriers to effective delivery, and localized delivery methods. It specifically addresses middle and inner ear diseases and their targeted drug delivery systems, including the use of hydrogels and nanocarriers for local delivery to the middle ear.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Thomas M. Kaffenberger, Michael A. Belsky, Nicholas R. Oberlies, Aarti Kumar, Joseph P. Donohue, Tiffany S. Yang, Amber D. Shaffer, David H. Chi
Summary: This study examined the impact of intraoperative middle ear effusion (MEE) types on outcomes of pediatric bilateral myringotomy and tympanostomy tube placement (BMT) surgeries. The results indicated that purulent effusions increased the odds of in-office suctioning in patients with recurrent acute otitis media (RAOM) compared to other types of MEE.
Article
Multidisciplinary Sciences
Chan Mi Lee, Yoon Young Go, Jae-Jun Song
Summary: This study demonstrates the anti-inflammatory effect of conditioned medium and extracellular vesicles derived from human trophoblast cells in treating otitis media. The underlying mechanism of cell migration during inflammatory healing was identified through RNA-sequencing analysis. This research holds significant clinical potential for treating chronic inflammation.
SCIENTIFIC REPORTS
(2023)
Review
Otorhinolaryngology
Kavya K. Pai, Ariel O. Omiunu, Dhiraj K. Peddu, Vivienne H. Au, Soly Baredes, Robert W. Jyung, Jean Anderson Eloy, Christina H. Fang
Summary: Tuberculous otitis media (TOM) is a rare extrapulmonary manifestation of tuberculosis (TB) that is challenging to diagnose due to non-specific symptoms. This systematic review analyzes clinical characteristics, diagnostic methods, and outcomes in 67 cases of TOM. The study finds that common symptoms of TOM include otorrhea, hearing loss, otalgia, and facial palsy. Tissue biopsy is a reliable diagnostic method, and early detection and management are recommended for optimal outcomes.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Sarah Callaham, Maxwell Newby, Aniket A. Saoji, Jad Ramadan, Michele M. Carr
Summary: WBT has potential use to differentiate types of MEE, with further studies needed to investigate its clinical application.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Microbiology
Steven L. Taylor, Lito E. Papanicolas, Alyson Richards, Furdosa Ababor, Wan Xian Kang, Jocelyn M. Choo, Charmaine Woods, Steve L. Wesselingh, Eng H. Ooi, Patricia MacFarlane, Geraint B. Rogers
Summary: This study in a remote Aboriginal community in South Australia found a variety of OM conditions in children, with ear microbiota characteristics related to OM diagnosis and changing with disease course. Nasopharyngeal microbiota characteristics were consistent with the contribution of acute upper respiratory infection to OM aetiology.
Article
Medicine, Research & Experimental
Zhuohui Liu, Tao Lu, Shumin Liu, Fan Zhang, Jinxiong Yang, Shumin Dai, Biao Ruan, Ruiqing Long
Summary: NEAT1 may attenuate LPS-induced inflammation and apoptosis in HMEECs by modulating the miR-301b-3p/TLR4 axis, providing a new therapeutic target for the clinical treatment of AOM.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Clinical Neurology
Michele Cavaliere, Antonella Miriam Di Lullo, Camilla Russo, Massimo Mesolella, Elena Cantone, Giuseppe Di Lorenzo, Gaetano Motta, Andrea Elefante
Summary: The study compares the accuracy of unstructured preoperative CT reports from non-tertiary diagnostic centers with intraoperative findings in patients with COM, suggesting discrepancies may be due to limited expertise of general radiologists in ENT neuroimaging. A structured checklist is proposed for optimizing communication with surgeons and providing crucial information for accurate surgical planning.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Apoorva Mulay, Md Miraj K. Chowdhury, Cameron T. James, Lynne Bingle, Colin D. Bingle
Summary: The study described a novel in vitro model of mouse middle ear epithelial cells and investigated the genome wide gene expression profiles as they underwent differentiation. Significant differences were found in gene expression among different cell populations, with upregulated genes associated mainly with the process of ciliogenesis during differentiation.
Article
Biotechnology & Applied Microbiology
Xiangru Yang, Qinna Zhang, Hui Lu, Chenxin Wang, Lijun Xia
Summary: This study reveals that MALAT1 promotes inflammatory response in LPS- or IL-17A-stimulated HMEECs through the NF-kappa B signaling pathway, providing a potential novel insight for the treatment of OM.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Computer Science, Artificial Intelligence
Zheng Wang, Jian Song, Ri Su, Muzhou Hou, Min Qi, Jianglin Zhang, Xuewen Wu
Summary: This paper developed a deep-learning framework called MESIC for diagnosing chronic middle ear diseases based on CT images, which can effectively identify cholesteatoma and chronic suppurative otitis media, helping alleviate the pressure on professional doctors and addressing the shortage of professional doctors in rural areas.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Pharmacology & Pharmacy
Manar Magdy, Enas Elmowafy, Mona Elassal, Rania A. H. Ishak
Summary: This research aimed to design and optimize innovative nanovesicles called Glycerospanlastics for delivering triamcinolone acetonide (TA) for otitis media treatment. The optimized Glycerospanlastics showed good properties such as nanometer size, negative charges, high TA entrapment, and improved permeation across the tympanic membrane. They outperformed the marketed drug suspension in treating otitis media, as evidenced by the restoration of histopathological alterations and reduced levels of IL-1 beta and TNF-alpha.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Jihye Rhee, Dongwook Lee, Hyun Jung Lim, Moo Kyun Park, Myung Whan Suh, Jun Ho Lee, Yun-Chul Hong, Seung-Ha Oh
Article
Nutrition & Dietetics
Sang-Yeon Lee, Gucheol Jung, Myoung-jin Jang, Myung-Whan Suh, Jun Ho Lee, Seung-Ha Oh, Moo Kyun Park
Article
Otorhinolaryngology
Hyun Soo Kim, Byeong-Gon Kim, Sohyeon Park, Nahyun Kim, An-Soo Jang, Young Rok Seo, Moo Kyun Park
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2020)
Article
Cell & Tissue Engineering
So Young Kim, Seung Ha Oh, Jun Ho Lee, Myung-Whan Suh, Moo Kyun Park
STEM CELLS INTERNATIONAL
(2019)
Article
Biochemical Research Methods
Thiago C. Cavalcanti, Sewoong Kim, Kyungsu Lee, Sang-Yeon Lee, Moo Kyun Park, Jae Youn Hwang
JOURNAL OF BIOPHOTONICS
(2020)
Article
Physiology
Byeong-Gon Kim, Moo-Kyun Park, Pureun-Haneul Lee, Sun-Hye Lee, Jisu Hong, Moh Moh Myint Aung, Khine Thandar Moe, Nyein Yu Han, An-Soo Jang
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2020)
Article
Genetics & Heredity
Mukesh Kumar Yadav, Yoon Young Go, Sung-Won Chae, Moo Kyun Park, Jae-Jun Song
FRONTIERS IN GENETICS
(2020)
Article
Multidisciplinary Sciences
Jihye Rhee, Dongwook Lee, Myung Whan Suh, Jun Ho Lee, Yun-Chul Hong, Seung Ha Oh, Moo Kyun Park
Article
Clinical Neurology
Tae-Soo Noh, Jeong-Sug Kyong, Moo Kyun Park, Jun Ho Lee, Seung Ha Oh, Myung-Whan Suh
Article
Medicine, Research & Experimental
Jin Youp Kim, Dong Su Lee, Hyun-Joon Woo, Hyung Gu Kim, Bu-Soon Son, Moo Kyun Park, Seung-No Hong
Summary: The study investigated the association between PM10 concentration and severity of rhinitis symptoms in 590 participants. Results showed a positive correlation between PM10 concentration and the severity and duration of rhinitis symptoms, particularly in non-allergic individuals.
Article
Multidisciplinary Sciences
Su Ji Kim, Nahyun Kim, So Hyeon Park, Hyun Soo Kim, Jae-Jun Song, Bu-Soon Son, An-Soo Jang, Moo Kyun Park, Young Rok Seo
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Sohyeon Park, Seung Hee Han, Byeong-Gon Kim, Myung-Whan Suh, Jun Ho Lee, Seung Ha Oh, Moo Kyun Park
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Toxicology
Hyun Soo Kim, Hyo Jeong Kim, Nahyun Kim, Jae-Jun Song, Bu-Soon Son, Jun Hyuek Yang, Cheol Min Lee, Moo Kyun Park, Young Rok Seo
TOXICOLOGY IN VITRO
(2020)
Article
Neurosciences
Miseung Koo, Jihui Jeon, Hwayoung Moon, Myungwhan Suh, Junho Lee, Seungha Oh, Mookyun Park
Summary: This preliminary study examined the effects of noise and stimulus presentation order on recall of spoken words and recorded pupil sizes. Higher reading span (RS) scores were associated with better performance in free recall tasks in both quiet and four-talker babble noise conditions. Results suggest a correlation between RS scores and free-recall scores.
Article
Multidisciplinary Sciences
Yunseo Ku, Do Youn Kim, Chiheon Kwon, Tae Soo Noh, Moo Kyun Park, Jun Ho Lee, Seung Ha Oh, Hee Chan Kim, Myung-Whan Suh