Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014
出版年份 2014 全文链接
标题
Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014
作者
关键词
-
出版物
JOURNAL OF INTERNAL MEDICINE
Volume 275, Issue 3, Pages 251-283
出版商
Wiley
发表日期
2014-03-09
DOI
10.1111/joim.12191
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Advances in the prevention of Alzheimer's disease and dementia
- (2014) A. Solomon et al. JOURNAL OF INTERNAL MEDICINE
- The neuroprotective and neurotrophic agent T-817MA for Alzheimer’s disease: Randomized, double-blind, placebo-controlled proof-of-concept trial outcomes
- (2013) Lon Schneider et al. Alzheimers & Dementia
- Mortality and Treatment Costs have a Great Impact on the Cost- Effectiveness of Disease Modifying Treatment in Alzheimer’s Disease - A Simulation Study
- (2013) Anders Skoldunger et al. Current Alzheimer Research
- A randomized controlled Alzheimer’s disease prevention trial’s evolution into an exposure trial: The preadvise trial
- (2013) R. J. Kryscio et al. Journal of Nutrition Health & Aging
- Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer's disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial
- (2013) Richard Dodel et al. LANCET NEUROLOGY
- Regulatory Innovation and Drug Development for Early-Stage Alzheimer's Disease
- (2013) Nicholas Kozauer et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effect of Immunotherapy With Bapineuzumab on Cerebrospinal Fluid Biomarker Levels in Patients With Mild to Moderate Alzheimer Disease
- (2012) Henrik Zetterberg ARCHIVES OF NEUROLOGY
- Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease
- (2012) Vladimir Coric et al. ARCHIVES OF NEUROLOGY
- EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo- Controlled, Double-Blind Study
- (2012) B. Vellas et al. Current Alzheimer Research
- Where, when, and in what form does sporadic Alzheimerʼs disease begin?
- (2012) Heiko Braak et al. CURRENT OPINION IN NEUROLOGY
- Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study
- (2012) Bengt Winblad et al. LANCET NEUROLOGY
- Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial
- (2012) Bruno Vellas et al. LANCET NEUROLOGY
- Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Reisa A. Sperling et al. Alzheimers & Dementia
- The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Guy M. McKhann et al. Alzheimers & Dementia
- The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Marilyn S. Albert et al. Alzheimers & Dementia
- Chronic Divalproex Sodium to Attenuate Agitation and Clinical Progression of Alzheimer Disease
- (2011) Pierre N. Tariot ARCHIVES OF GENERAL PSYCHIATRY
- Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)
- (2011) Paul S. Aisen et al. Archives of Medical Science
- Lack of Evidence for the Efficacy of Memantine in Mild Alzheimer Disease
- (2011) Lon S. Schneider ARCHIVES OF NEUROLOGY
- Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab
- (2011) Susanne Ostrowitzki ARCHIVES OF NEUROLOGY
- Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment
- (2011) Suzanne Craft ARCHIVES OF NEUROLOGY
- Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
- (2011) Orestes V. Forlenza et al. BRITISH JOURNAL OF PSYCHIATRY
- AFFITOME® technology in neurodegenerative diseases: The doubling advantage
- (2011) Achim Schneeberger et al. Human vaccines & immunotherapeutics
- A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease
- (2011) S. Salloway et al. NEUROLOGY
- A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
- (2011) M. Sano et al. NEUROLOGY
- Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift
- (2011) Todd E. Golde et al. NEURON
- A Randomized Pilot Clinical Trial of the Safety of Pioglitazone in Treatment of Patients With Alzheimer Disease
- (2010) David S. Geldmacher et al. ARCHIVES OF NEUROLOGY
- Intravenous Immunoglobulins as a Treatment for Alzheimerʼs Disease
- (2010) Richard Dodel et al. DRUGS
- Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease
- (2010) Joseph F. Quinn et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Revising the definition of Alzheimer's disease: a new lexicon
- (2010) Bruno Dubois et al. LANCET NEUROLOGY
- 11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
- (2010) Juha O Rinne et al. LANCET NEUROLOGY
- Alzheimer's disease: clinical trials and drug development
- (2010) Francesca Mangialasche et al. LANCET NEUROLOGY
- Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
- (2010) H. H. Feldman et al. NEUROLOGY
- Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial
- (2010) A. David Smith et al. PLoS One
- Current Alzheimer's disease clinical trials: Methods and placebo outcomes
- (2009) Lon S. Schneider et al. Alzheimers & Dementia
- A Combination Therapy of Donepezil and Cilostazol for Patients With Moderate Alzheimer Disease: Pilot Follow-Up Study
- (2009) Heii Arai et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer’s Disease: The OmegAD Study
- (2009) Yvonne Freund-Levi et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial
- (2009) Robert C. Green JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Lithium Trial in Alzheimer's Disease
- (2009) Harald Hampel et al. JOURNAL OF CLINICAL PSYCHIATRY
- What we have learned from the xaliproden Sanofi-aventis trials
- (2009) P. Douillet et al. Journal of Nutrition Health & Aging
- Effect of tramiprosate in patients with mild-to-moderate alzheimer’s disease: Exploratory analyses of the MRI sub-group of the alphase study
- (2009) S. Gauthier et al. Journal of Nutrition Health & Aging
- A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
- (2009) S. Salloway et al. NEUROLOGY
- Donepezil treatment of patients with MCI: A 48-week randomized, placebo-controlled trial
- (2009) R. S. Doody et al. NEUROLOGY
- O3-04-07: Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks
- (2008) Claude M. Wischik et al. Alzheimers & Dementia
- High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease
- (2008) Paul S. Aisen JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Ginkgo biloba for Prevention of DementiaA Randomized Controlled Trial
- (2008) Steven T. DeKosky JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
- (2008) Clive Holmes et al. LANCET
- Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
- (2008) Lars Lannfelt et al. LANCET NEUROLOGY
- Endpoints for trials in Alzheimer's disease: a European task force consensus
- (2008) Bruno Vellas et al. LANCET NEUROLOGY
- Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial
- (2008) Gordon K Wilcock et al. LANCET NEUROLOGY
- Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial
- (2008) Ruth Peters et al. LANCET NEUROLOGY
- Growth hormone secretagogue MK-677: No clinical effect on AD progression in a randomized trial
- (2008) J. J. Sevigny et al. NEUROLOGY
- Safety and efficacy of galantamine in subjects with mild cognitive impairment
- (2008) B. Winblad et al. NEUROLOGY
- Prevention therapeutics of dementia
- (2007) Lon S. Schneider Alzheimers & Dementia
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