标题
The challenge of intratumour heterogeneity in precision medicine
作者
关键词
-
出版物
JOURNAL OF INTERNAL MEDICINE
Volume 276, Issue 1, Pages 41-51
出版商
Wiley
发表日期
2014-03-25
DOI
10.1111/joim.12240
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Bringing precision medicine to the clinic: from genomic profiling to the power of clinical observation
- (2013) J. Baselga ANNALS OF ONCOLOGY
- Can Stroma Reaction Predict Cancer Lethality?
- (2013) M. R. Freeman et al. CLINICAL CANCER RESEARCH
- Genome evolution during progression to breast cancer
- (2013) D. E. Newburger et al. GENOME RESEARCH
- Tracking the clonal origin of lethal prostate cancer
- (2013) Michael C. Haffner et al. JOURNAL OF CLINICAL INVESTIGATION
- Precision Oncology: An Overview
- (2013) Levi A. Garraway et al. JOURNAL OF CLINICAL ONCOLOGY
- Circulating tumour cells: insights into tumour heterogeneity
- (2013) D. F. Hayes et al. JOURNAL OF INTERNAL MEDICINE
- Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling
- (2013) Ali Bashashati et al. JOURNAL OF PATHOLOGY
- Precision Medicine for Cancer Patients: Lessons Learned and the Path Forward
- (2013) A. F. Gazdar et al. JNCI-Journal of the National Cancer Institute
- PET imaging of oestrogen receptors in patients with breast cancer
- (2013) Michel van Kruchten et al. LANCET ONCOLOGY
- Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: The role of massively parallel sequencing
- (2013) Leticia De Mattos-Arruda et al. Molecular Oncology
- Tumour heterogeneity in the clinic
- (2013) Philippe L. Bedard et al. NATURE
- The causes and consequences of genetic heterogeneity in cancer evolution
- (2013) Rebecca A. Burrell et al. NATURE
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- Influence of tumour micro-environment heterogeneity on therapeutic response
- (2013) Melissa R. Junttila et al. NATURE
- Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
- (2013) Muhammed Murtaza et al. NATURE
- Liquid biopsy: monitoring cancer-genetics in the blood
- (2013) Emily Crowley et al. Nature Reviews Clinical Oncology
- Circulating tumour cells and cell-free DNA as tools for managing breast cancer
- (2013) Leticia De Mattos-Arruda et al. Nature Reviews Clinical Oncology
- Circulating Tumor DNA to Monitor Metastatic Breast Cancer
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Pilot Studies for Personalized Cancer Medicine: Focusing on the Patient for Treatment Selection
- (2013) L. De Mattos-Arruda et al. ONCOLOGIST
- Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
- (2013) A. Sottoriva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis
- (2013) L. Zhang et al. Science Translational Medicine
- The roots of cancer: Stem cells and the basis for tumor heterogeneity
- (2012) Maho Shibata et al. BIOESSAYS
- Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
- (2012) Jeffrey A. Magee et al. CANCER CELL
- Intratumor Heterogeneity: Evolution through Space and Time
- (2012) C. Swanton CANCER RESEARCH
- Formation and regulation of the cancer stem cell niche
- (2012) Nobuyuki Takakura CANCER SCIENCE
- The Life History of 21 Breast Cancers
- (2012) Serena Nik-Zainal et al. CELL
- The Harmonies Played by TGF-β in Stem Cell Biology
- (2012) Naoki Oshimori et al. Cell Stem Cell
- Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center Initiative
- (2012) A.-M. Tsimberidou et al. CLINICAL CANCER RESEARCH
- Heterogeneity of Epidermal Growth Factor Receptor Status and Mutations of KRAS/PIK3CA in Circulating Tumor Cells of Patients with Colorectal Cancer
- (2012) C. Gasch et al. CLINICAL CHEMISTRY
- Feasibility of real time next generation sequencing of cancer genes linked to drug response: Results from a clinical trial
- (2012) Ben Tran et al. INTERNATIONAL JOURNAL OF CANCER
- Genetic heterogeneity and cancer drug resistance
- (2012) Nicholas C Turner et al. LANCET ONCOLOGY
- Sequence analysis of mutations and translocations across breast cancer subtypes
- (2012) Shantanu Banerji et al. NATURE
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- Clonal selection drives genetic divergence of metastatic medulloblastoma
- (2012) Xiaochong Wu et al. NATURE
- What are we learning from the cancer genome?
- (2012) Eric A. Collisson et al. Nature Reviews Clinical Oncology
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intra- and Inter-Tumor Heterogeneity of BRAFV600EMutations in Primary and Metastatic Melanoma
- (2012) Molly Yancovitz et al. PLoS One
- Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines
- (2012) Ashley A. Powell et al. PLoS One
- Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer
- (2012) R. A. Beckman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA
- (2012) T. Forshew et al. Science Translational Medicine
- Intratumor Heterogeneity: Seeing the Wood for the Trees
- (2012) T. A. Yap et al. Science Translational Medicine
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer
- (2011) M. Hidalgo et al. MOLECULAR CANCER THERAPEUTICS
- Tumour evolution inferred by single-cell sequencing
- (2011) Nicholas Navin et al. NATURE
- Mapping copy number variation by population-scale genome sequencing
- (2011) Ryan E. Mills et al. NATURE
- Integrated genomic analyses of ovarian carcinoma
- (2011) D. Bell et al. NATURE
- WIN Consortium—challenges and advances
- (2011) John Mendelsohn et al. Nature Reviews Clinical Oncology
- Implications of personalized medicine—perspective from a cancer center
- (2011) Thomas Tursz et al. Nature Reviews Clinical Oncology
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Personalized Oncology Through Integrative High-Throughput Sequencing: A Pilot Study
- (2011) S. Roychowdhury et al. Science Translational Medicine
- The BATTLE Trial: Personalizing Therapy for Lung Cancer
- (2011) Edward S. Kim et al. Cancer Discovery
- A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer
- (2011) A. Bertotti et al. Cancer Discovery
- TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma
- (2010) Judit Anido et al. CANCER CELL
- Pilot Study Using Molecular Profiling of Patients' Tumors to Find Potential Targets and Select Treatments for Their Refractory Cancers
- (2010) Daniel D. Von Hoff et al. JOURNAL OF CLINICAL ONCOLOGY
- Radiolabelled receptor-tyrosine-kinase targeting drugs for patient stratification and monitoring of therapy response: prospects and pitfalls
- (2010) Vladimir Tolmachev et al. LANCET ONCOLOGY
- Genome remodelling in a basal-like breast cancer metastasis and xenograft
- (2010) Li Ding et al. NATURE
- Distant metastasis occurs late during the genetic evolution of pancreatic cancer
- (2010) Shinichi Yachida et al. NATURE
- International network of cancer genome projects
- (2010) Thomas J. Hudson (Chairperson) et al. NATURE
- Advances in understanding cancer genomes through second-generation sequencing
- (2010) Matthew Meyerson et al. NATURE REVIEWS GENETICS
- Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
- (2010) Eunice L. Kwak et al. NEW ENGLAND JOURNAL OF MEDICINE
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma
- (2009) Silvia Peñuelas et al. CANCER CELL
- Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution
- (2009) Mark Shackleton et al. CELL
- I-SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy
- (2009) AD Barker et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
- (2009) Peter C. Fong et al. NEW ENGLAND JOURNAL OF MEDICINE
- The HER-2 Receptor and Breast Cancer: Ten Years of Targeted Anti-HER-2 Therapy and Personalized Medicine
- (2009) J. S. Ross et al. ONCOLOGIST
- Stem cell concepts renew cancer research
- (2008) J. E. Dick BLOOD
- Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib
- (2008) Kazuya Taniguchi et al. CANCER SCIENCE
- Implications of the Cancer Stem-Cell Hypothesis for Breast Cancer Prevention and Therapy
- (2008) Madhuri Kakarala et al. JOURNAL OF CLINICAL ONCOLOGY
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now