Manganese toxicity in the central nervous system: the glutamine/glutamate-γ-aminobutyric acid cycle

The Protective Effects of Riluzole on Manganese-Induced Disruption of Glutamate Transporters and Glutamine Synthetase in the Cultured Astrocytes

(2012) Yu Deng et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Mechanism of Mn(II)-mediated dysregulation of glutamine-glutamate cycle: focus on glutamate turnover

(2012) Marta Sidoryk-Wegrzynowicz et al.   JOURNAL OF NEUROCHEMISTRY

Disruption of astrocytic glutamine turnover by manganese is mediated by the protein kinase C pathway

(2011) Marta Sidoryk-Wegrzynowicz et al.   GLIA

Protein Kinase C-dependent Ubiquitination and Clathrin-mediated Endocytosis of the Cationic Amino Acid Transporter CAT-1

(2011) Arnau Vina-Vilaseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C-Mediated Phosphorylation of a Single Serine Residue on the Rat Glial Glutamine Transporter SN1 Governs Its Membrane Trafficking

(2011) L. S. H. Nissen-Meyer et al.   JOURNAL OF NEUROSCIENCE

Changes in the Striatal Proteome of YAC128Q Mice Exhibit Gene–Environment Interactions between Mutant Huntingtin and Manganese

(2011) Michal Wegrzynowicz et al.   JOURNAL OF PROTEOME RESEARCH

Patterns of levels of biological metals in CSF differ among neurodegenerative diseases

(2011) Isao Hozumi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Motor function in adults of an Ohio community with environmental manganese exposure

(2011) Yangho Kim et al.   NEUROTOXICOLOGY

Rapid downregulation of the rat glutamine transporter SNAT3 by a caveolin-dependent trafficking mechanism in Xenopus laevis oocytes

(2010) Sarojini Balkrishna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Manganese induces the overexpression of α-synuclein in PC12 cells via ERK activation

(2010) Tongjian Cai et al.   BRAIN RESEARCH

In Vivo Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese

(2010) Ulrike Dydak et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Manganese-induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin-mediated proteolytic system

(2010) Marta Sidoryk-Wȩgrzynowicz et al.   GLIA

APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2010) Tomás R. Guilarte   NEUROTOXICOLOGY

Protein kinase C isoforms: Multi-functional regulators of cell life and death

(2009) Mary et al.   Frontiers in Bioscience-Landmark

SNAT2 Amino Acid Transporter Is Regulated by Amino Acids of the SLC6 γ-Aminobutyric Acid Transporter Subfamily in Neocortical Neurons and May Play No Role in Delivering Glutamine for Glutamatergic Transmission

(2009) Sukhjeevan Grewal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes

(2009) Eun-Sook Y. Lee et al.   JOURNAL OF NEUROCHEMISTRY

Manganese disrupts astrocyte glutamine transporter expression and function

(2009) Marta Sidoryk-Węgrzynowicz et al.   JOURNAL OF NEUROCHEMISTRY

Disease-toxicant screen reveals a neuroprotective interaction between Huntington’s disease and manganese exposure

(2009) B. Blairanne Williams et al.   JOURNAL OF NEUROCHEMISTRY

From Manganism to Manganese-Induced Parkinsonism: A Conceptual Model Based on the Evolution of Exposure

(2009) Roberto G. Lucchini et al.   NEUROMOLECULAR MEDICINE

Effects of Chronic Manganese Exposure on Glutamatergic and GABAergic Neurotransmitter Markers in the Nonhuman Primate Brain

(2009) Neal C. Burton et al.   TOXICOLOGICAL SCIENCES

Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures

(2008) Zhaoobao Yin et al.   BRAIN RESEARCH

Molecular mechanism of manganese exposure-induced dopaminergic toxicity

(2008) K. Prabhakaran et al.   BRAIN RESEARCH BULLETIN

Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates

(2008) Neal C. Burton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

PKC-dependent endocytosis of the GLT1 glutamate transporter depends on ubiquitylation of lysines located in a C-terminal cluster

(2008) Inmaculada M. González-gonzález et al.   GLIA

Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCδ proteolytic activation and mitochondrial translocation

(2008) Faneng Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phorbol ester induced trafficking-independent regulation and enhanced phosphorylation of the dopamine transporter associated with membrane rafts and cholesterol

(2008) James D. Foster et al.   JOURNAL OF NEUROCHEMISTRY

Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2008) Tomás R. Guilarte et al.   JOURNAL OF NEUROCHEMISTRY

Differential Tonic GABA Conductances in Striatal Medium Spiny Neurons

(2008) K. K. Ade et al.   JOURNAL OF NEUROSCIENCE

Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity

(2008) Keith M. Erikson et al.   NEUROTOXICOLOGY

Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brain

(2008) Joel G. Anderson et al.   NEUROTOXICOLOGY

Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester

(2007) Bala T.S. Susarla et al.   NEUROCHEMISTRY INTERNATIONAL

Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders

(2007) Dixin Wang et al.   TOXICOLOGY LETTERS