期刊
JOURNAL OF INTERNAL MEDICINE
卷 274, 期 3, 页码 203-214出版社
WILEY
DOI: 10.1111/joim.12096
关键词
apoptosis; beta cells; diabetes; GLP-1; insulin secretion; pregnancy
资金
- Swiss National Science Foundation [3100A0-113525]
- National Center of Competence in Research 'Frontiers in Genetics'
- Innovative Medicine Initiative Joint Undertaking [155005]
- European Union
- EFPIA
In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hyperglycaemia. Incomplete understanding of the molecular mechanisms controlling the plasticity of adult beta cells mechanisms and how these cells fail during the pathogenesis of diabetes strongly limits the ability to develop new beta cell-specific therapies. Here, current knowledge of the signalling pathways controlling beta cell plasticity is reviewed, and possible directions for future research are discussed.
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