Article
Clinical Neurology
Simon Frerich, Rainer Malik, Marios K. Georgakis, Moritz F. Sinner, Steven J. Kittner, Braxton D. Mitchell, Martin Dichgans
Summary: This study used genetic data to assess the associations between cardiac traits and stroke risk, finding that cardiac traits have limited effects on stroke risk beyond known clinical risk factors.
Article
Cardiac & Cardiovascular Systems
Hidehiro Kaneko, Yuichiro Yano, Akira Okada, Hidetaka Itoh, Yuta Suzuki, Isao Yokota, Kojiro Morita, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Satoko Yamaguchi, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Toshimasa Yamauchi, Masaomi Nangaku, Takashi Kadowaki, John W. McEvoy, Carolyn S. P. Lam, Hideo Yasunaga, Issei Komuro
Summary: The contribution of modifiable risk factors to the development of cardiovascular disease is greater in younger individuals, suggesting that preventive efforts for risk factor modification may be more effective in younger people.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Matthew Chun, Robert Clarke, Tingting Zhu, David Clifton, Derrick Bennett, Yiping Chen, Yu Guo, Pei Pei, Jun Lv, Canqing Yu, Ling Yang, Liming Li, Zhengming Chen, Benjamin J. Cairns
Summary: The study found that the risk estimates of stroke for individuals increase annually, with different annual increase rates for men and women, and using machine learning methods to integrate longitudinal data has value for stroke prediction.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Marta Gruca, Justyna Zamojska, Katarzyna Niewiadomska-Jarosik, Agnieszka Wosiak, Aleksandra Stasiak, Karolina Sikorska, Jerzy Stanczyk, Elzbieta Smolewska
Summary: The aim of this study was to assess CVD risk factors in patients with JIA. IMT, metabolic parameters and health behaviors were evaluated. The study found that CVD risk factors were present in both groups, with more JIA patients having abnormal BMI compared to the control group. Dietary habits were not associated with IMT or other parameters in the JIA group. Only one JIA patient met the criteria for ideal cardiovascular health. The pursuit of ideal cardiovascular health should be given attention in the pediatric population, especially in patients with chronic diseases like JIA. Further studies are needed to apply carotid artery IMT measurement in assessing CVD risk.
Article
Public, Environmental & Occupational Health
Demosthenes Panagiotakos, Christina Chrysohoou, Evangelia Damigou, Fotios Barkas, Evangelos Liberopoulos, Costas Tsioufis, Petros P. Sfikakis, ATTICA Study Grp
Summary: This study aimed to predict lifetime risk for cardiovascular disease (CVD). The results showed that men and women had similar lifetime CVD risk, with the risk declining as age increased. These findings can guide resource allocation and improve public health and preventive services, especially for individuals under the age of 50.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Fahad Mohammad Sulaiteen, Ibrahim Abdulaziz Al-Zaagi, Majed Sultan Alenazi, Amani Zaben Alotaibi, Tahani Aali Alghamdi, Anum Yousaf, Sheraz Ali
Summary: Community pharmacists in Saudi Arabia have satisfactory knowledge of cardiovascular disease risk factors, with the frequency of contact with diabetic patients and age being associated with their knowledge level.
Article
Cardiac & Cardiovascular Systems
Yasina B. Somani, Laween Uthman, Vincent L. Aengevaeren, Laura Rodwell, Gregory Y. H. Lip, Maria T. E. Hopman, Niels Van Royen, Thijs M. H. Eijsvogels, Dick H. J. Thijssen
Summary: Prolonged exercise can lead to the release of cardiac troponin. The magnitude of troponin release decreases with successive days of exercise in healthy individuals and those with cardiovascular risk factors, but not in patients with established cardiovascular disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Timothy E. O'Toole, Xiaohong Li, Daniel W. Riggs, David J. Hoetker, Shahid P. Baba, Aruni Bhatnagar
Summary: The study found significant associations between nonconjugated carnosine and cardiovascular risk factors like hypertension and heart failure, while carnosine conjugates were significantly associated with diabetes and HDL levels. This suggests that carnosine and its conjugates may be informative biomarkers for assessing CVD risk, especially in relation to diabetes and skeletal muscle injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Jennifer J. Stuart, Lauren J. Tanz, Eric B. Rimm, Donna Spiegelman, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: This study aimed to evaluate the association between hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) and identify the proportion mediated by established CVD risk factors. The results showed that women with HDP during their first pregnancy had a higher risk of CVD, which was mainly mediated by established CVD risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Oncology
Harry Klimis, Jehonathan H. Pinthus, Nazanin Aghel, Emmanuelle Duceppe, Vincent Fradet, Ian Brown, D. Robert Siemens, Bobby Shayegan, Laurence Klotz, Patrick P. Luke, Tamim Niazi, Luke T. Lavallee, Negareh Mousavi, Robert J. Hamilton, Joseph L. Chin, Darin Gopaul, Philippe D. Violette, Margot K. Davis, Nawar Hanna, Robert Sabbagh, Osnat Itzhaki Ben Zadok, Ludhmila Abrahao Hajjar, Ariel Galapo Kann, Rajibul Mian, Sumathy Rangarajan, Kelvin Kuan Huei, Zaza Iakobishvili, Joseph B. Selvanayagam, Alvaro Avezum, Darryl P. Leong
Summary: This study aimed to investigate the rate and correlates of poor cardiovascular risk factor control among men with prostate cancer. It found that almost all participants had at least one uncontrolled cardiovascular risk factor, with 51% having poor overall risk factor control. Not taking statins, physical frailty, need for blood pressure medication, and age were identified as key factors associated with poor overall risk factor control.
JACC: CARDIOONCOLOGY
(2023)
Review
Medicine, General & Internal
Kieran Maroney, Jodie Laurent, Flor Alvarado, Alexandra Gabor, Caryn Bell, Keith Ferdinand, Jiang He, Katherine T. Mills
Summary: Church-based interventions have been shown to effectively reduce CVD risk factors, particularly in populations with health disparities. Increasing physical activity, improving diet, stress management, medication adherence, and smoking cessation are commonly used approaches in these interventions.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Cimmino, Francesco Natale, Roberta Alfieri, Luigi Cante, Simona Covino, Rosa Franzese, Mirella Limatola, Luigi Marotta, Riccardo Molinari, Noemi Mollo, Francesco S. Loffredo, Paolo Golino
Summary: Cardiovascular diseases are a major global health issue, causing death and reduced quality of life. Identifying and managing modifiable risk factors is crucial for prevention, but emerging factors have also impacted assessment.
Article
Cardiac & Cardiovascular Systems
Matti A. Vuori, Jaakko Reinikainen, Stefan Soderberg, Ellinor Bergdahl, Pekka Jousilahti, Hugh Tunstall-Pedoe, Tanja Zeller, Dirk Westermann, Susana Sans, Allan Linneberg, Licia Iacoviello, Simona Costanzo, Veikko Salomaa, Stefan Blankenberg, Kari Kuulasmaa, Teemu J. Niiranen
Summary: The main mediators of heart failure in diabetes are obesity, hyperglycemia, and cardiac strain/volume overload. Conventional cardiovascular risk factors are strongly related to incident heart failure, but these associations are not stronger in diabetic than in non-diabetic individuals. Active measurement of relevant biomarkers could potentially be used to improve prevention and prediction of heart failure in high-risk diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alessio Petrelli, Gabriella Sebastiani, Anteo Di Napoli, Alessandra Macciotta, Paola Di Filippo, Elena Strippoli, Concetta Mirisola, Angelo d'Errico
Summary: This study evaluated the impact of education differences on the incidence of cardiovascular disease (CVD) and coronary heart disease (CHD) in Italy, as well as the role of behavioral and biological risk factors (BBRF). The findings revealed a higher risk of CVD and CHD among individuals with lower education levels. BBRF played a significant mediating role in the education inequalities.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Nutrition & Dietetics
Ulrike Siewert-Markus, Sabina Ulbricht, Beate Gaertner, Birgit-Christiane Zyriax, Marcus Doerr, Stefanie Tobschall, Sophie Baumann, Ulrich John, Jennis Freyer-Adam
Summary: Little is known about the (co-)occurrence and motivation to change behavioral health risk factors in older general hospital patients with cardiovascular disease. A survey conducted on consecutively admitted patients aged 50 to 79 years revealed a notable co-occurrence of behavioral health risk factors, with the majority of older adults considering changing their behaviors. Hospitalization may be an opportune time for systematic screening and intervention.
Review
Cardiac & Cardiovascular Systems
Shreya Rao, Tariq Jamal Siddiqi, Muhammad Shahzeb Khan, Erin D. Michos, Ann Marie Navar, Thomas J. Wang, Stephen J. Greene, Dorairaj Prabhakaran, Amit Khera, Ambarish Pandey
Summary: Polypill use is associated with reductions in cardiovascular disease risk factors, total mortality risk, and major adverse cardiovascular events, particularly in low-risk and primary prevention populations.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Fisheries
Yahui Yang, Duo Jin, Wensu Long, Ximiao Lai, Yunjun Sun, Feng Zhai, Pan Wang, Xixun Zhou, Yibo Hu, Liqiu Xia, Ganfeng Yi
Summary: The strain Z1-26 of Streptomyces lateritius, isolated from soil samples, exhibited broad-spectrum antibacterial activity against various fish pathogens. Feeding crucian carp with strain Z1-26 resulted in improved growth performance, antioxidant capacity, and immune response. In addition, Z1-26 supplementation significantly enhanced the survival rate of fish infected with Aeromonas hydrophila. Whole genome analysis revealed the presence of multiple gene clusters in strain Z1-26, indicating its potential as a candidate probiotic for controlling bacterial diseases in aquaculture.
JOURNAL OF FISH DISEASES
(2023)
Article
Fisheries
Shijia Yang, Duo Jin, Hui Li, Lingzhi Jiang, Jun Cui, Weitao Huang, Jie Rang, YunLong Li, Liqiu Xia
Summary: In this study, a new strain of Paenibacillus polymyxa S3 with antibacterial activity against various fish pathogens was screened and evaluated for its probiotic function. The strain was found to colonize and distribute in grass carp, improving their growth rate, antioxidant capacity, immune function, and survival rate against Aeromonas hydrophila infection.
JOURNAL OF FISH DISEASES
(2023)
Article
Fisheries
Hu Yang, Jia Li, Huizhong Xu, Chunfeng Peng, Jun Cui, Shengbiao Hu, Liqiu Xia, Youming Zhang
Summary: This study investigated the antioomycete effect, mechanism, and application of acidic electrolytic water (AEW) on Saprolegnia. The results showed that AEW had an antioomycete effect on both Saprolegnia mycelium and spores. AEW mainly affected the normal physiological function of mycelium by destroying the cell membrane structure and causing content leakage. AEW has potential application to prevent and control saprolegniasis in the aquaculture industry.
AQUACULTURE INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Kevin R. Bersell, Tao Yang, Jonathan D. Mosley, Andrew M. Glazer, Andrew T. Hale, Dmytro O. Kryshtal, Kyungsoo Kim, Jeffrey D. Steimle, Jonathan D. Brown, Joe-Elie Salem, Courtney C. Campbell, Charles C. Hong, Quinn S. Wells, Amanda N. Johnson, Laura Short, Marcia A. Blair, Elijah R. Behr, Evmorfia Petropoulou, Yalda Jamshidi, Mark D. Benson, Michelle J. Keyes, Debby Ngo, Ramachandran S. Vasan, Qiong Yang, Robert E. Gerszten, Christian Shaffer, Shan Parikh, Quanhu Sheng, Prince J. Kannankeril, Ivan P. Moskowitz, John D. York, Thomas J. Wang, Bjorn C. Knollmann, Dan M. Roden
Summary: Brugada syndrome (BrS) is caused by loss-of-function variants in the SCN5A gene, but a family with BrS and a rare TBX5 variant has been identified. The study found that the TBX5 variant decreased SCN5A transcription, resulting in enhanced late sodium current (I-Na) and other electrophysiological abnormalities. Additionally, abnormal PDGF/PI3K signaling was found to be associated with the development of Brugada syndrome.
Article
Fisheries
Junzhi Zhang, Ziqing Wang, Yong Shi, Liqiu Xia, Yi Hu, Lei Zhong
Summary: In this study, the protective effects of chlorogenic acid (CGA) supplementation on oxidative stress-induced damage in channel catfish were investigated. It was found that consumption of oxidized fish oil led to decreased growth performance, disrupted intestinal structure, hepatic oxidative stress, and inflammation, as well as impaired muscle development and skin coloration in the catfish. However, supplementation of CGA in the diet partially counteracted these negative effects, improving growth performance, intestinal structure, hepatic antioxidant capacity, and skin coloration. Overall, CGA shows great potential as an aquatic feed additive for channel catfish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jinzhi Zhao, Yi Yang, Hua Xu, Jianxujie Zheng, Chengpin Shen, Tian Chen, Tao Wang, Bing Wang, Jia Yi, Dan Zhao, Enhui Wu, Qin Qin, Li Xia, Liang Qiao
Summary: DirectDIA method shows superior performance in quantitative metaproteomics, providing valuable insights into the metabolic protein profiles of intestinal microbiota and related diseases.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Cell Biology
Chih-Ling Wang, Rika Ohkubo, Wei-Chieh Mu, Wei Chen, Jiang Lan Fan, Zehan Song, Ayane Maruichi, Peter H. Sudmant, Angela O. Pisco, Dena B. Dubal, Na Ji, Danica Chen
Summary: Aging leads to a decline in neural stem cells, neurogenesis, and cognitive function. Recent evidence shows disrupted adult neurogenesis in the hippocampus of patients with neurodegenerative disorders. Single-cell RNA sequencing reveals that mitochondrial protein folding stress is prominent in activated neural stem cells/neural progenitors in the neurogenic niche, and it increases with aging, leading to dysregulated cell cycle and mitochondrial activity. This stress compromises neural stem cell maintenance and reduces neurogenesis, resulting in neural hyperactivity and impaired cognitive function. Reducing mitochondrial protein folding stress improves neurogenesis and cognitive function in old mice, suggesting a potential approach to alleviate aging-associated cognitive decline.
Article
Oncology
Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen
Summary: In this study, it was found that FBXO22 is highly expressed in MLLr AML and promotes AML progression by targeting BACH1 for degradation. Knockdown of FBXO22 leads to increased apoptosis in MLLr leukemia cells and reduced LSCs in serial transplantations. Targeting FBXO22 could be an ideal strategy to eradicate LSCs without affecting normal hematopoiesis.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Reza Mohebi, Dongyu Wang, Emily S. Lau, Juhi K. Parekh, Norrina Allen, Bruce M. Psaty, Emelia J. Benjamin, Daniel Levy, Thomas J. Wang, Sanjiv J. Shah, John S. Gottdiener, James L. Januzzi, Jennifer E. Ho
Summary: This study compares the prevalence and prognosis of heart failure (HF) stages according to the 2013 and 2022 ACC/AHA/HFSA definitions. The new standards result in a substantial shift of individuals from stage A to stage B, and those in stage B have a higher risk of progression to symptomatic HF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Ecology
Joana L. Rocha, Pedro Silva, Nuno Santos, Monia Nakamura, Sandra Afonso, Abdeljebbar Qninba, Zbyszek Boratynski, Peter H. Sudmant, Jose C. Brito, Rasmus Nielsen, Raquel Godinho
Summary: Analysis of whole genomes of four fox species shows that introgression facilitated adaptation to the hot arid environment of the Sahara Desert and suggests renal water homeostasis as a mechanism of adaptation in the extreme desert specialist species.
NATURE ECOLOGY & EVOLUTION
(2023)
Article
Biology
Li Wan, Peilei Hu, Lili Zhang, Zhao-Xi Wang, Joy Fleming, Bo Ni, Jianjun Luo, Cha-Xiang Guan, Liqiong Bai, Yunhong Tan, Haican Liu, Na Li, Tongyang Xiao, Hua Bai, Yong-An Zhang, Xian-En Zhang, Kanglin Wan, Lijun Bi, Songying Ouyang, Hongtai Zhang
Summary: A multi-omic analysis of 11 Mycobacterium tuberculosis (Mtb) isolates with different drug resistance profiles leads to the discovery of Rv3094c, an enzyme capable of activating the clinically relevant Mtb drug, ethionamide.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemical Research Methods
Chen-Shan Chin, Sairam Behera, Asif Khalak, Fritz J. Sedlazeck, Peter H. Sudmant, Justin Wagner, Justin M. Zook
Summary: By using PGR-TK, we can analyze complex genome structures and haplotype variations. We demonstrate the capability of PGR-TK in analyzing the class II major histocompatibility complex, Y-chromosome genes associated with male infertility, and X-chromosome genes linked to eye disorders. Furthermore, we showcase its application in 395 complex repetitive medically important genes, highlighting its ability to resolve complex variations in previously unanalyzable regions of the genome.
Article
Hematology
Li-Xue Yang, Cheng-Tao Zhang, Meng-Ying Yang, Xue-Hong Zhang, Hong-Chen Liu, Chen -Hui Luo, Yue Jiang, Zhang-Man Wang, Zhong-Yin Yang, Zhao -Peng Shi, Yi-Ci Yang, Ruo-Qu Wei, Li Zhou, Jun Mi, Ai -Wu Zhou, Zhi-Rong Yao, Li Xia, Jin-Song Yan, Ying Lu
Summary: Single-cell RNA sequencing revealed a subset of complement C1Q(+) macrophage-like leukemia cells enriched in the skin of AML patients with EMI. C1Q expression was associated with adverse prognosis and mediated communication with fibroblasts, promoting tissue infiltration and survival under chemotherapy stress. Hence, C1Q serves as a marker for poor prognosis in AML and represents a promising therapeutic target for EMI.
Meeting Abstract
Gastroenterology & Hepatology
Thomas J. Wang, Jordan S. Sack, Marvin Ryou
