☆ 4.7 Article

C-reactive protein lowering with rosuvastatin in the METEOR study

JOURNAL OF INTERNAL MEDICINE (2010)

期刊

JOURNAL OF INTERNAL MEDICINE

卷 268, 期 2, 页码 155-161

出版社

WILEY

DOI: 10.1111/j.1365-2796.2010.02230.x

关键词

carotid intima media thickness; clinical trials; inflammation; preventive medicine; statins; ultrasound

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Medicine, General & Internal

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AstraZeneca

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摘要

Peters SAE, Palmer MK, Grobbee DE, Crouse JR III, O'Leary DH, Raichlen JS, Bots ML (Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; Keele University, Keele, UK; Wake Forest University School of Medicine, Winston-Salem, NC, USA; Caritas Carney Hospital, Boston, MA, USA; AstraZeneca, Wilmington, DE, USA). C-reactive protein lowering with rosuvastatin in the METEOR study. J Intern Med 2010; 268: 155-161. Objectives. In addition to its LDL-C-lowering effects, statin treatment reduces the level of C-reactive protein (CRP). Long-term data on this effect in low-risk populations are limited. Furthermore, whether the CRP reduction is a consequence of LDL-C lowering or occurs independently remains unclear. We studied these aspects in the Measuring Effects on intima media Thickness: an Evaluation Of Rosuvastatin (METEOR) study, a randomized placebo-controlled trial amongst 984 low-risk subjects. Methods. METEOR is a randomized placebo-controlled trial that evaluated the effect of 40 mg of rosuvastatin on 2-year change in carotid intima media thickness (CIMT) amongst 984 low-risk patients (10-year Framingham risk < 10%) with modest CIMT (CIMT >= 1.2 and < 3.5 mm) and elevated LDL-C. CRP levels were measured at baseline and after 2 years of treatment. Results. Median baseline CRP was 1.4 mg L-1. Rosuvastatin lowered CRP significantly compared with placebo: -36% in the rosuvastatin group versus no change in the placebo group. There was no relation between change in CRP and change in LDL-C (Spearman correlation: 0.08; SE: 0.04). Stratified analyses showed that the CRP-lowering effect was present amongst all strata of baseline characteristics, including baseline lipids and CRP levels. However, the magnitude of CRP reduction was larger amongst women and participants older than 60 years. Conclusions. Rosuvastatin (40 mg) lowers CRP independently from its effects on LDL-C in low-risk subjects with normal baseline CRP levels and modest CIMT.

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BSMNet: Boundary-salience multi-branch network for intima-media identification in carotid ultrasound images

Guang-Quan Zhou, Hao Wei, Xiaoyi Wang, Kai-Ni Wang, Yuzhao Chen, Fei Xiong, Guanqing Ren, Chunying Liu, Le Li, Qinghua Huang

Summary: In this work, we propose an end-to-end boundary-salience multi-branch network, BSMNet, to identify the carotid intima-media from ultrasound images. Our method exploits prior shape knowledge and anatomical dependence to improve the accuracy of boundary identification and incorporates a strip attention model for segmenting thin strip regions. Experimental results demonstrate the promising performance of our method, achieving about 0.02 improvement in Dice and HD95 compared to other state-of-the-art methods. Our method is expected to advance the analysis of systemic arterial disease with ultrasound imaging.

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