Article
Biochemistry & Molecular Biology
Ulf Hedstrom, Lisa Oberg, Outi Vaarala, Goran Dellgren, Martin Silverborn, Leif Bjermer, Gunilla Westergren-Thorsson, Oskar Hallgren, Xiaohong Zhou
Summary: The study found that airway epithelial cells in patients with Chronic Obstructive Pulmonary Disease (COPD) are damaged, and COPD epithelial cells show differential gene expression on COPD airway scaffolds compared to normal epithelial cells, with increased proliferation and maintained basal cell phenotype.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Han Liu, Pengbei Fan, Fanli Jin, Hui Ren, Feng Xu, Jiansheng Li
Summary: COPD is responsible for high disability rates, high death rates, and significant cost to health systems. Recent research has shown significant biophysical microenvironment changes in COPD, which have the potential to be novel targets for improved COPD treatment strategies. Both pharmacological and non-pharmacological therapies can repair the biophysical microenvironment of the lung.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Critical Care Medicine
Ana I. Hernandez Cordero, Chen Xi Yang, Julia Yang, Steve Horvath, Tawimas Shaipanich, Julia MacIsaac, David T. S. Lin, Michael S. Kobor, Silvia Guillemi, Marianne Harris, Wan Lam, Stephen Lam, Julio Montaner, S. F. Paul Man, Don D. Sin, Janice M. Leung
Summary: By analyzing the DNA methylation and gene expression of bronchial epithelial brushings from PLWH, it was found that methylation age acceleration and shorter methylation estimates of telomere length were observed in PLWH with COPD, which may contribute to the increased risk of COPD in this population. The distinct methylation profile of PLWH with COPD, different from that of patients with COPD alone, suggests a unique pathogenesis for HIV-associated COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Maria-Elpida Christopoulou, Eleni Papakonstantinou, Daiana Stolz
Summary: Matrix metalloproteinases (MMPs) are proteolytic enzymes that regulate airway remodeling and may contribute to the development of emphysema in chronic obstructive pulmonary disease (COPD). This literature review examines the role of different MMPs in COPD, their regulation by tissue inhibitors, and the potential therapeutic targeting of MMPs in COPD. Recent clinical trials supporting this approach are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Immunology
Stefanie Krick, E. Scott Helton, Molly Easter, Seth Bollenbecker, Rebecca Denson, Rennan Zaharias, Phillip Cochran, Shia Vang, Elex Harris, James M. Wells, Jarrod W. Barnes
Summary: This study suggests that the reduced expression of ST6GAL1 and alpha 2-6 sialylation could lead to increased IL-6 expression and secretion in human bronchial epithelial cells (HBECs), and could be associated with poor clinical outcomes in COPD. Exposures to cigarette smoke or BACE1 inhibition resulted in decreased ST6GAL1 secretion, reduced alpha 2-6 sialylation, and increased IL-6 production in HBECs. Plasma ST6GAL1 levels demonstrated an inverse association with prospective acute exacerbations of COPD, while IL-6 was positively associated.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Samir Rustam, Yang Hu, Seyed Babak Mahjour, Andre F. Rendeiro, Hiranmayi Ravichandran, Andreacarola Urso, Frank D'Ovidio, Fernando J. Martinez, Nasser K. Altorki, Bradley Richmond, Vasiliy Polosukhin, Jonathan A. Kropski, Timothy S. Blackwell, Scott H. Randell, Olivier Elemento, Renat Shaykhiev
Summary: The remodeling and loss of distal conducting airways, including preterminal and terminal bronchioles, contribute to progressive airflow limitation in COPD. However, the cellular mechanisms underlying these structural changes are still unknown.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Dian Chen, Rongbing Yi, Weifeng Hong, Kai Wang, Yahong Chen
Summary: This study found that the small airway epithelium in patients with chronic obstructive pulmonary disease (COPD) has a survival mechanism against detachment, which is closely associated with disease progression and immune status. TNMD was identified as one of the key molecules involved in this process.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Stanislav Kotlyarov
Summary: Chronic obstructive pulmonary disease (COPD) is a common disease characterized by progressive airflow limitation due to chronic inflammation in the bronchi. The mechanisms of the innate immune system play a role in the pathogenesis of COPD, leading to chronic inflammation and lung tissue damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Respiratory System
Nancy Gomez, Victoria James, David Onion, Lucy C. Fairclough
Summary: This systematic review examines the role of extracellular vesicles (EVs) in the pathogenesis and diagnosis of Chronic Obstructive Pulmonary Disease (COPD). The research found that EVs are involved in the mechanism of COPD pathogenesis, derived from various cell types and containing modified levels of miRNAs. The findings suggest that EVs could be a potential method for COPD diagnosis and progress monitoring.
RESPIRATORY RESEARCH
(2022)
Article
Critical Care Medicine
Jeffrey T-J Huang, Erin Cant, Holly R. Keir, Alun K. Barton, Elena Kuzmanova, Morven Shuttleworth, Jennifer Pollock, Simon Finch, Eva Polverino, Mathieu Bottier, Alison J. Dicker, Amelia Shoemark, James D. Chalmers
Summary: This study investigated the sputum microbiome and proteome in patients with bronchiectasis, COPD, and the COPD-bronchiectasis association, proposing five endotypes with differential inflammatory, mucin, and microbiological features. The key traits related to the COPD-bronchiectasis association include neutrophilic inflammation, differential mucin expression, and Gram-negative infection.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Editorial Material
Multidisciplinary Sciences
John V. Fahy, Richard M. Locksley
Summary: Smoking leads to chronic obstructive pulmonary disease (COPD). Some COPD patients exhibit elevated levels of eosinophil cells, indicating type 2 inflammation, and blocking this inflammation can enhance their lung health.
Article
Medicine, Research & Experimental
Rosalia Gagliardo, Fabio Bucchieri, Angela Marina Montalbano, Giusy Daniela Albano, Delphine Gras, Alberto Fucarino, Roberto Marchese, Giulia Anzalone, Chiara Lo Nigro, Pascal Chanez, Mirella Profita
Summary: The airway epithelium plays a critical role in the pathophysiology of COPD, with dysregulation of Oct4, CD146, and CD105 expression induced by cigarette smoke exposure potentially exacerbating airway epithelial dysfunction and contributing to disease progression.
Review
Cell Biology
Binay Kumar Shah, Bivek Singh, Yukun Wang, Shuanshuan Xie, Changhui Wang
Summary: Most COPD patients suffer from excessive production of airway mucus, leading to symptoms such as cough and expectoration. This chronic mucus hypersecretion (CMH) is a major contributor to the increased morbidity and mortality in certain subsets of COPD patients. It is crucial to develop medications that can effectively suppress mucus hypersecretion to improve their outcomes.
MEDIATORS OF INFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Margaret Warner, Jan-Ake Gustafsson
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2015)
Review
Cell Biology
Bo Huang, Margaret Warner, Jan-Ake Gustafsson
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Y-B Dai, W-F Wu, B. Huang, Y-F Miao, S. Nadarshina, M. Warner, J-A Gustafsson
MOLECULAR PSYCHIATRY
(2016)
Article
Multidisciplinary Sciences
Laure Maneix, Per Antonson, Patricia Humire, Sabrina Rochel-Maia, Jessica Castaneda, Yoko Omoto, Hyun-Jin Kim, Margaret Warner, Jan-Ake Gustafsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Yifei Miao, Wanfu Wu, Yubing Dai, Laure Maneix, Bo Huang, Margaret Warner, Jan-Ake Gustafsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Yu-bing Dai, Yi-fei Miao, Wan-fu Wu, Yu Li, Francesca D'Errico, Wen Su, Alan R. Burns, Bo Huang, Laure Maneix, Margaret Warner, Jan-Ake Gustafsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Multidisciplinary Sciences
Bo Huang, Ryan Butler, Yifei Miao, Yubing Dai, Wanfu Wu, Wen Su, Yoshiaki Fujii-Kuriyama, Margaret Warner, Jan-Ake Gustafsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Review
Pharmacology & Pharmacy
Margaret Warner, Bo Huang, Jan-Ake Gustafsson
TRENDS IN PHARMACOLOGICAL SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Chiara Gabbi, Margaret Warner, Jan-Ake Gustafsson
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Biochemistry & Molecular Biology
H. Suzuki, R. P. A. Barros, N. Sugiyama, V. Krishnan, B. C. Yaden, H-J Kim, M. Warner, J-A Gustafsson
MOLECULAR PSYCHIATRY
(2013)
Review
Biochemistry & Molecular Biology
M. Warner, J-A Gustafsson
MOLECULAR PSYCHIATRY
(2015)
Article
Biochemistry & Molecular Biology
P. Xu, H. Xu, X. Tang, L. Xu, Y. Wang, L. Guo, Z. Yang, Y. Xing, Y. Wu, M. Warner, J-A Gustafsson, X. Fan
MOLECULAR PSYCHIATRY
(2014)
Editorial Material
Medicine, General & Internal
Margaret Warner, Jan-Ake Gustafsson
NEW ENGLAND JOURNAL OF MEDICINE
(2014)
Article
Multidisciplinary Sciences
Bo Huang, Yoko Omoto, Hirotaka Iwase, Hiroko Yamashita, Tatsuya Toyama, Raoul Charles Coombes, Aleksandra Filipovic, Margaret Warner, Jan-Ake Gustafsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Multidisciplinary Sciences
Yi-fei Miao, Wen Su, Yu-bing Dai, Wan-Fu Wu, Bo Huang, Rodrigo P. A. Barros, Hao Nguyen, Laure Maneix, You-fei Guan, Margaret Warner, Jan-Ake Gustafsson
SCIENTIFIC REPORTS
(2016)