Article
Multidisciplinary Sciences
Ousman Jobe, Jiae Kim, Daniel O. Pinto, Zuzana Villar, Tiffany Hewitt, Elizabeth H. Duncan, Alexander Anderson, Neelakshi Gohain, Hua Gong, Courtney Tucker, Carl R. Alving, Gary R. Matyas, Elke Bergmann-Leitner, Mangala Rao
Summary: Monocyte-derived macrophages (MDM) are highly susceptible to HIV-1 infection due to the downregulation of innate factors during differentiation. Activation of MDM and upregulation of anti-viral factors, particularly APOBEC3A, can decrease permissiveness to HIV-1 infection. This study highlights the relationship between innate immune activation, proinflammatory environment, and upregulation of anti-HIV proteins, which can switch MDM into a less susceptible phenotype.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F. Dickson, Jonas Weidenhausen, Shannon Smyly, Ji-Chun Yang, Sarah L. Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C. James
Summary: TRIM proteins are the largest family of E3 ligases in mammals, and the ubiquitination mechanism of TRIM ligases has been unclear. However, this study reveals that ligase ubiquitination is not necessary for substrate degradation during Trim-Away.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Ann-Katrin Menzner, Tanja Rottmar, Simon Voelkl, Jacobus J. Bosch, Dimitrios Mougiakakos, Andreas Mackensen, Yazid J. Resheq
Summary: The study highlights the crucial role of metabolism in tumor immune evasion, with hepatic stromal cells controlling H2O2 metabolism to induce immunosuppressive properties in monocytic cells. By unraveling the complex interaction between cholesterol/LDL and H2O2 metabolism, the research sheds new light on the potential for improving immunotherapeutic approaches against cancer.
Article
Cardiac & Cardiovascular Systems
Cristhian A. Gutierrez-Huerta, Briana S. Turner, Sophie E. Claudel, Nicole Farmer, Rafique Islam, Valerie M. Mitchell, Billy S. Collins, Yvonne Baumer, Alan T. Remaley, Tiffany M. Powell-Wiley
Summary: This study found differences in the immune cell profile between African Americans (AAs) and Caucasians, and demonstrated that lipid content was associated with differences in monocyte subsets among AAs. LDL treatment induced phenotypic changes in monocytes and altered the expression of specific chemokine receptors. Understanding these molecular mechanisms could have therapeutic benefits for cardiovascular disease (CVD) in high-risk populations.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Virology
Moises A. Huaman, Manuel G. Feria, Cissy Kityo, Sophie Nalukwago, Rashidah Nazzinda, David A. Zidar, Markella V. Zanni, Mark J. Siedner, Steven K. Grinspoon, Chris T. Longenecker
Summary: Women with HIV may experience higher rates of non-AIDS comorbidities compared to men with HIV, and there are sex-related differences in monocyte phenotypes. However, our study found that HIV affects monocyte subsets similarly in both men and women, without significant interactions between sex and HIV status.
Article
Cell Biology
Pauline Esteves, Benoit Allard, Alexis Celle, Isabelle Dupin, Elise Maurat, Olga Ousova, Matthieu Thumerel, Jean-William Dupuy, Thierry Leste-Lasserre, Roger Marthan, Pierre-Olivier Girodet, Thomas Trian, Patrick Berger
Summary: This study shows that asthmatic bronchial smooth muscle (BSM) cells enhance the replication of rhinovirus (RV) in bronchial epithelium through increased production of CCL20. Additionally, these asthmatic BSM cells downregulate the antiviral pathway PKR, leading to increased susceptibility of the bronchial epithelium to RV infection.
Article
Immunology
Moises A. Huaman, Steven M. Juchnowski, David A. Zidar, Cissy M. Kityo, Sophie Nalukwago, Rashidah Nazzinda, Carl J. Fichtenbaum, Chris T. Longenecker
Summary: The study found that in HIV-infected individuals with LTBI or prior active TB, there was enhanced monocyte activation, which may contribute to the pathogenesis of noncommunicable diseases.
Article
Infectious Diseases
Andreas D. Knudsen, Randa Bouazzi, Shoaib Afzal, Marco Gelpi, Thomas Benfield, Julie Hogh, Magda Teresa Thomsen, Marius Troseid, Borge G. Nordestgaard, Susanne D. Nielsen
Summary: This study found that HIV infection is associated with lower monocyte count and higher concentrations of monocyte activation markers.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Moira A. McMahon, Meghdad Rahdar, Swagatam Mukhopadhyay, Huynh-Hoa Bui, Christopher Hart, Sagar Damle, Margo Courtney, Michael W. Baughn, Don W. Cleveland, Frank Bennett
Summary: Antisense oligonucleotides (ASOs) are synthetic nucleic acids that bind to RNA to alter gene expression. A functional genomic screen identified GOLGA8 as a novel regulator that enhances ASO activity, leading to increased uptake and improved splice modulation. GOLGA8 is localized to the trans-Golgi and plasma membrane, and overexpression enhances RNase H1-dependent ASOs as well.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Immunology
Bo L. Honge, Morten N. Andersen, Mikkel S. Petersen, Sanne Jespersen, Candida Medina, David D. S. Te, Bertram Kjerulff, Alex L. Laursen, Holger J. Moller, Christian Wejse, Henrik Krarup, Bjarne K. Moller, Christian Erikstrup
Summary: AIDS-defining illness develops at higher CD4+ T-cell counts in individuals infected with HIV-2 compared with HIV-1-infected, which suggests that the two types of HIV may have different effects on other compartments of the immune system. This study investigated monocyte phenotype, activation, and macrophage-derived extracellular vesicles in individuals with different HIV types. The results showed that HIV-2-positive participants had a less deviated monocyte phenotype from healthy controls and a lower concentration of extracellular CD206 vesicles compared with HIV-1-positive participants.
Article
Biochemistry & Molecular Biology
Yun Zhang, Doudou Dong, Xiaoting Xu, Hui He, Yuan Zhu, Tingwen Lei, Hailong Ou
Summary: This study reveals a causal link between oxHDL and CD36 palmitoylation, providing insights into foam cell formation and atherogenesis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Juan Lin, Erik Ehinger, David Hanna, Qibin Qi, Tao Wang, Yanal Ghosheh, Karin Mueller, Kathryn Anastos, Jason M. Lazar, Wendy J. Mack, Phyllis C. Tien, Joan W. Berman, Mardge H. Cohen, Igho Ofotokun, Stephen Gange, Chenglong Liu, Sonya L. Heath, Russell P. Tracy, Howard N. Hodis, Alan L. Landay, Klaus Ley, Robert C. Kaplan
Summary: Persistent inflammation, driven by monocytes, contributes to cardiovascular disease (CVD) as a comorbidity in individuals with HIV. This study examined the role of specific types of monocytes (NCM and IM) in the host response to HIV infection and HIV-associated CVD. The findings suggest that circulating NCM and IM have distinct gene expression profiles in women with HIV, and the presence of CVD further amplifies these gene transcriptional changes.
Article
Cell Biology
Luis Vazquez-Flores, Jessica Castaneda-Casimiro, Luis Vallejo-Castillo, Violeta D. Alvarez-Jimenez, Eliud S. Peregrino, Mariano Garcia-Martinez, Dante Barreda, Victor Hugo Rosales-Garcia, C. David Segovia-Garcia, Teresa Santos-Mendoza, Carlos Wong-Baeza, Jeanet Serafin-Lopez, Rommel Chacon-Salinas, Sergio Estrada-Parra, Iris Estrada-Garcia, Isabel Wong-Baeza
Summary: Tuberculosis remains a major global public health problem. This study found that extracellular vesicles released by human neutrophils infected with Mycobacterium tuberculosis contain host proteins and mycobacterial antigens. These vesicles are able to activate the adaptive immune response by transferring mycobacterial proteins to antigen-presenting cells. This research highlights the importance of extracellular vesicles in immune cell communication during tuberculosis infection.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Immunology
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina M. Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M. C. Boehner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Roesen-Wolff, Lino L. Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
Summary: The study identifies abnormal DNA recognition and IFN-I production as drivers of severe ANCA-associated vasculitis, and demonstrates that blocking this pathway can ameliorate the disease and accelerate recovery, suggesting potential therapeutic targets for patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tomozumi Imamichi, Suranjana Goswami, Xiaojun Hu, Sylvain Laverdure, Jun Yang, Ju Qiu, Qian Chen, Brad T. Sherman, Weizhong Chang
Summary: IL-27 treatment led to the discovery of 38 novel miRNAs in differentiated macrophages, with 16 of them being differentially regulated. Overexpression of miRAB40 showed potent HIV-inhibiting and autophagy-inducing properties, partially mediated via IFN-dependent and -independent pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)