Article
Clinical Neurology
Maciej Jurynczyk, Elzbieta Klimiec-Moskal, Yazhuo Kong, Samuel Hurley, Silvia Messina, Tianrong Yeo, Mark Jenkinson, Maria Isabel Leite, Jacqueline Palace
Summary: This study identified four distinct subgroups within the antibody-negative NMOSD/MS overlap syndrome, each with different pathological features and MRI findings. Tailored treatment based on these subgroup classifications may optimize outcomes for challenging patients in the NMOSD/MS cohort.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Ren Wei, Xiaolu Xu, Yunyun Duan, Ningnannan Zhang, Jie Sun, Haiqing Li, Yuxin Li, Yongmei Li, Chun Zeng, Xuemei Han, Fuqing Zhou, Muhua Huang, Runzhi Li, Zhizheng Zhuo, Frederik Barkhof, James H. Cole, Yaou Liu
Summary: This study evaluated the clinical significance of deep learning-derived brain age prediction in NMOSD and RRMS. The results showed that both NMOSD and RRMS patients had a significantly higher brain age gap compared to healthy controls. The brain age gap was associated with baseline disability score, advanced brain volume loss, and disease duration. Additionally, the brain age gap predicted the worsening of disability status in both NMOSD and RRMS patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica and its spectrum is a relapsing demyelinating disorder of the central nervous system, encompassing six syndromes and associated with aquaporin-4 autoantibodies. Effective treatment is able to prevent relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica, previously known as Devic's disease, is a relapsing demyelinating disorder of the central nervous system that encompasses six syndromes and is associated with aquaporin-4 autoantibodies. Effective treatment is crucial in preventing relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mark M. Melamud, Evgeny A. Ermakov, Anastasiia S. Boiko, Daria A. Kamaeva, Alexey E. Sizikov, Svetlana A. Ivanova, Natalia M. Baulina, Olga O. Favorova, Georgy A. Nevinsky, Valentina N. Buneva
Summary: The study revealed that 11 cytokines were increased in the cytokine profile of systemic lupus erythematosus patients, while 10 cytokines were significantly decreased in multiple sclerosis patients. These changes were associated with dysregulation of interleukins, TNF superfamily members, and chemokines in SLE, and abnormal levels of growth factors and chemokines in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Eun Bin Cho, Se Young Jung, Jin-Hyung Jung, Yohwan Yeo, Hee Jin Kim, Kyungdo Han, Dong Wook Shin, Ju-Hong Min
Summary: A population-based study in South Korea found that patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) have an increased risk of developing dementia, with MS patients having a higher risk compared to NMOSD patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Juan Zhang, Mei-Jiao Chen, Gui-Xian Zhao, Hong-Fu Li, Lei Wu, Yong-Feng Xu, Yajin Liao, Zengqiang Yuan, Zhi-Ying Wu
Summary: The study explored the association between PRRC2A variants and susceptibility to NMOSD and MS in the Han Chinese population. Certain PRRC2A variants were found to alter susceptibility to AQP4(+)NMOSD and MS, with specific genotypes increasing the risk. Additionally, haplotypes and gene expression levels associated with these variants were identified, suggesting potential implications for personalized therapeutic approaches in these disease entities.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Romina Mariano, Silvia Messina, Adriana Roca-Fernandez, Maria Leite, Yazhuo Kong, Jacqueline A. Palace
Summary: Spinal cord involvement is a key feature of multiple sclerosis, neuromyelitis optica with AQP4 antibodies, and MOG-antibody disease. Quantitative spinal cord MRI was used in a cross-sectional study to differentiate these conditions, showing significant damage in AQP4-antibody disease and multiple sclerosis, while MOG-antibody disease had a predominant central grey matter component. The study also found that relapsing MOG-antibody disease is a more severe phenotype and applied various analyses to discriminate between different diseases.
Article
Clinical Neurology
Burak Arslan, Gokce Ayhan Arslan, Asli Tuncer, Rana Karabudak, Aylin Sepici Dincel
Summary: This pilot study evaluated dynamic thiol-disulfide homeostasis as an oxidative stress parameter in neuroimmunological diseases, finding a significant relationship between clinical features and thiol homeostasis. Serum biomarkers of thiol homeostasis differed from CSF levels, indicating a potential role in monitoring disease activity.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Fudong Shi, Umer Asgher, Nils Muhlert, Yaou Liu, Jinhui Wang
Summary: This study investigated the impact of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) on the cerebellar connectome. The findings showed both shared and specific alterations in the connectome between MS and NMOSD, with MS patients exhibiting increased morphological connectivity within the cerebellar secondary motor module and NMOSD patients showing increased connectivity between the cerebellar primary motor module and cerebral motor- and sensory-related areas. Additionally, both diseases had decreased functional connectivity between cerebellar motor modules and cerebral association cortices.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Cong-Cong Fu, Cong Gao, Hui-Hua Zhang, Ying-Qing Mao, Jing-Qiao Lu, Brianne Petritis, Andy S. Huang, Xin-Guang Yang, You-Ming Long, Ruo-Pan Huang
Summary: This study found that there were 39 differentially expressed serological proteins in NMOSD patients compared to healthy controls, with 29 of these proteins not observed in MS patients. In addition, there were differentially expressed proteins between AQP4-IgG seronegative and AQP4-IgG seropositive NMOSD patients, as well as between NMOSD patients without AQP4-IgG and MS patients without AQP4-IgG.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Peng Peng Ip, Qiongyu Li, Wei-Han Lin, Chien-Ching Chang, Cathy Shen-Jang Fann, Huan-Yuan Chen, Fu-Tong Liu, Carlito B. Lebrilla, Chih-Chao Yang, Fang Liao
Summary: Glycosylation plays a key role in protein biological functions and can be used to understand disease etiology, differentiate diseases, and develop therapeutics. Differences in glycosylation profiles of serum proteins between patients with remitting multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) were observed. Site-specific N-glycans on certain proteins were identified as potential markers to differentiate between MS and NMOSD. Monitoring serum protein glycan profiles using high-throughput analysis may provide additional diagnostic criteria for differentiating diseases and assessing treatment effects.
Article
Clinical Neurology
Laura Clarke, Simon Arnett, Wajih Bukhari, Elham Khalilidehkordi, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M. Prain, Mark Woodhall, Roger Silvestrini, Christine S. Bundell, David A. Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J. Brew, Wallace Brownlee, Helmut Butzkueven, William M. Carroll, Cella Chen, Alan Coulthard, Russell C. Dale, Chandi Das, Marzena J. Fabis-Pedrini, David Gillis, Simon Hawke, Robert Heard, Andrew P. D. Henderson, Saman Heshmat, Suzanne Hodgkinson, Trevor J. Kilpatrick, John King, Christopher Kneebone, Andrew J. Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A. L. Macdonell, Deborah F. Mason, Pamela A. McCombe, Jennifer Pereira, John D. Pollard, Sudarshini Ramanathan, Stephen W. Reddel, Cameron P. Shaw, Judith M. Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C. Wong, Eppie M. Yiu, Michael H. Barnett, Allan G. K. Kermode, Mark P. Marriott, John D. E. Parratt, Mark Slee, Bruce Taylor, Ernest Willoughby, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A. Broadley
Summary: Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS with overlapping clinical and MRI features, but distinguishing them can be achieved with the use of MRI features and machine learning models.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Mario Habek, Marko Andabaka, Alessandra Fanciulli, Gregor Brecl Jakob, Jelena Drulovic, Fabian Leys, Franziska Di Pauli, Harald Hegen, Michael Auer, Tatjana Pekmezovic, Sarlota Mesaros, Vanja Jovicevic, Anamari Junakovic, Gregor K. Wenning, Florian Deisenhammer, Tereza Gabelic, Barbara Barun, Ivan Adamec, Magdalena Krbot Skoric
Summary: This study aimed to determine the extent of sudomotor dysfunction in patients with neuromyelitis optica spectrum disorder (pwNMOSD) and compare it with patients with relapsing-remitting multiple sclerosis (pwRRMS). The results showed that sudomotor dysfunction is common in pwNMOSD, and symptoms are more frequent compared to pwRRMS. Age and diagnosis of neuromyelitis optica spectrum disorder were significant predictors for symptomatic sudomotor dysfunction.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Frederike Cosima Oertel, Svenja Specovius, Hanna G. Zimmermann, Claudia Chien, Seyedamirhosein Motamedi, Charlotte Bereuter, Lawrence Cook, Marco Aurelio Lana Peixoto, Mariana Andrade Fontanelle, Ho Jin Kim, Jae-Won Hyun, Jacqueline Palace, Adriana Roca-Fernandez, Maria Isabel Leite, Srilakshmi Sharma, Fereshteh Ashtari, Rahele Kafieh, Alireza Dehghani, Mohsen Pourazizi, Lekha Pandit, Anitha D'Cunha, Orhan Aktas, Marius Ringelstein, Philipp Albrecht, Eugene May, Caryl Tongco, Letizia Leocani, Marco Pisa, Marta Radaelli, Elena H. Martinez-Lapiscina, Hadas Stiebel-Kalish, Sasitorn Siritho, Jerome de Seze, Thomas Senger, Joachim Havla, Romain Marignier, Alvaro Cobo Calvo, Denis Bichuetti, Ivan Maynart Tavares, Nasrin Asgari, Kerstin Soelberg, Ayse Altintas, Rengin Yildirim, Uygur Tanriverdi, Anu Jacob, Saif Huda, Zoe Rimler, Allyson Reid, Yang Mao-Draayer, Ibis Soto de Castillo, Axel Petzold, Ari J. Green, Michael R. Yeaman, Terry Smith, Alexander U. Brandt, Friedemann Paul
Summary: This study highlights the importance of attack prevention to avoid severe neuroaxonal damage and vision loss caused by ON in NMOSD. Therapies to ameliorate attack-related damage, especially during the first attack, are a clinical need. Mild neuroaxonal changes in ON-unaffected eyes may be solely due to contralateral ON attacks and do not indicate clinically relevant progression, but require further investigation.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)