Review
Cell Biology
Hui Yang, Bruce Beutler, Duanwu Zhang
Summary: The spliceosome, while crucial for cell function, can also be implicated in diseases and serve as a target for cancer therapy. Research has shown connections between the spliceosome and immune signaling, leading to immune dysregulation. Furthermore, core spliceosome components have splicing-independent immune functions, adding to their functional diversity.
Article
Fisheries
Ge Qin, Xiang Yu, Yuanjie Zhao, Xiaoping Li, Beibei Yu, Hui Peng, Diqi Yang
Summary: The expression of NLRP9 was examined in piglets and IPECJ2 cells, and it was found that NLRP9 had high levels of mRNA and protein expression in the intestine of piglets and IPEC-J2 cells. Furthermore, it was demonstrated that NLRP9 acts in combination with VIM to participate in porcine intestinal antiviral innate immunity. These findings provide preliminary insights into the molecular mechanisms involved in the regulation of mucosal immunity in the porcine intestine by NLRP9.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Immunology
Xiaoxin Ji, Wei Meng, Zichuan Liu, Xin Mu
Summary: This article summarizes the roles of long noncoding RNAs (lncRNAs) in modulating the RNA-activated IFN-I signaling pathway. By analyzing the event order during the signaling, the regulatory mechanisms of lncRNAs in this pathway are revealed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Wentao Zhang, Yanling Li, Shuyu Xin, Li Yang, Mingjuan Jiang, Yujie Xin, Yiwei Wang, Pengfei Cao, Senmiao Zhang, Yang Yang, Jianhong Lu
Summary: IFIT3 is an important protein induced by interferon, playing a role in antiviral innate immunity and regulating cellular biology. It has the potential to serve as a biomarker for disease diagnosis and therapy.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chunfu Zheng
Summary: Members of the MARCH family play important roles in regulating immune system and protein transport in cells, especially in antiviral immune responses. Studies have shown that MARCH affects viral replication by regulating the activity of signaling molecules, impacting host immune defense systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Virology
Chuan Kok Lim, Bang Manh Tran, Dustin Flanagan, Erin Mccartney, Edmund Tse, Elizabeth Vincan
Summary: This study evaluated the application of intrahepatic cholangiocyte organoids (ICOs) model in hepatitis B virus (HBV) infection and cellular responses. The results showed that human ICOs can support HBV infection and replication, but did not upregulate interferon-stimulated genes (ISGs). These findings are important for the development of personalized antiviral drugs.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chunfu Zheng
Summary: Recent studies have revealed the emerging role of NLRs in antiviral innate immune signaling pathways, yet the underlying mechanisms are still not fully understood.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Virology
Chunfu Zheng, Yan-Dong Tang
Summary: This article introduces the role of CDKs family members in the cell cycle and emphasizes their emerging role in antiviral innate immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sanjaya K. Sahu, Devesha H. Kulkarni, Ayse N. Ozanturk, Lina Ma, Hrishikesh S. Kulkarni
Summary: The complement system not only protects the intravascular space from encapsulated bacteria but also plays a role in protecting against non-encapsulated pathogens. Specific complement proteins recognize and interact with pathogens, locally derived complement proteins are important in host defense, and intracellular complement proteins facilitate local protection and barrier function.
TRENDS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Meilin Chen, Yijun Liu, Yuqin Yang, Yanbing Qiu, Zhicheng Wang, Xiaoxu Li, Wenling Zhang
Summary: Activating transcription factors (ATFs) are a group of bZIP transcription factors that play important roles in maintaining homeostasis by responding to extracellular signals. ATFs have diverse functions in cell proliferation, apoptosis, differentiation, and inflammation-related processes. Their expression and phosphorylation status are also associated with neurodegenerative diseases and polycystic kidney disease. miRNAs target ATFs to regulate cancer proliferation, apoptosis, autophagy, and sensitivity/resistance to radiotherapy and chemotherapy. Understanding the regulation and function of ATFs provides insights into the basic mechanisms of cellular responses mediated by transcription factors. Dysfunction of ATFs is crucial in cancer biology and treatment, making the characterization of ATF dysfunction important for therapeutic strategies.
Review
Immunology
Xiuzhi Jia, Chunyuan Zhao, Wei Zhao
Summary: The MHC-I region contains a cluster of E3 ubiquitin ligase genes that play important roles in controlling innate immune responses. This review highlights the regulatory roles of these ligases in innate immunity, and outlines their potential functions in infection, inflammation, and autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ansul Lokdarshi, Albrecht G. von Arnim
Summary: The pan-eukaryotic protein kinase GCN2 regulates mRNA translation in response to external and metabolic conditions. In plants, GCN2 has assumed novel functions, including innate immunity and retrograde signaling. However, there are still unresolved questions regarding the divergence of the GCN2 system in green plants, such as whether GCN2 regulates amino acid biosynthesis and the role of phosphorylation of eIF2 alpha in translation control.
Article
Virology
Yu Han, Xue Bai, Siying Liu, Jingfei Zhu, Fan Zhang, Lifen Xie, Guodi Liu, Xiaohui Jiang, Mingchao Zhang, Yingkang Huang, Jingfeng Wang, Dapei Li, Huiying Zhang, Yuanqing He, Sudan He, Yu Xia, Xiulong Xu, Feng Xu, Feng Ma
Summary: This study reveals the crucial role of XAF1 in enhancing interferon-induced apoptosis and combating RNA virus infections. XAF1 stabilizes IRF1 protein and induces the expression of antiviral genes, thereby strengthening the host's antiviral innate immunity.
JOURNAL OF VIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joshua D. Samuels, John R. Lukens, Richard J. Price
Summary: Microglia play a critical role in Alzheimer's disease and understanding the regulation of their innate immune responses is important for therapeutic development. This review summarizes the functions of microglia in response to amyloid beta plaques and discusses the role of innate immune receptors and intracellular signaling in guiding these functions.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Microbiology
Li Yi, Chunfu Zheng
Summary: Post-translational modifications play a crucial role in expanding protein diversity. Fatty acylation modification is emerging as a novel regulatory mechanism of antiviral innate immunity. Palmitoylation has been shown to play a key role in host antiviral innate immunity against viruses.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)