Article
Biochemistry & Molecular Biology
Alberto Carreno, Jens Lykke-Andersen
Summary: This study investigates the regulation of mRNA decay activator TTP by the p38 MAPK-MK2 pathway. The results show that the UP CIM recruits the CCR4-NOT deadenylase complex and activates mRNA degradation cooperatively with the conserved tryptophan residues of UP. Interestingly, the UP CIM remains unphosphorylated and can still promote association with the CCR4-NOT complex and mRNA decay upon activation of the p38-MAPK-activated kinase MK2.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Neurosciences
Houmin Lin, Steven Grant Dixon, Wei Hu, Eric D. Hamlett, Junfei Jin, Adviye Ergul, Gavin Y. Wang
Summary: Research suggests that the accumulation of amyloid beta (Aβ) plaques in the brain is a key factor in the development of Alzheimer's disease (AD). This study found that Aβ(1-40) oligomers stimulate the expression of IL-6 in human microglial cells. The activation of p38 MAPK is associated with this increase in IL-6. Inhibition of p38 MAPK can prevent Aβ-induced IL-6 production. These findings indicate that targeting p38 MAPK could be a potential approach to reduce neuroinflammation caused by Aβ accumulation in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Takuya Nagai, Tomohisa Sekimoto, Syuji Kurogi, Tomomi Ohta, Shihoko Miyazaki, Yoichiro Yamaguchi, Takuya Tajima, Etsuo Chosa, Mai Imasaka, Kumiko Yoshinobu, Kimi Araki, Masatake Araki, Narantsog Choijookhuu, Katsuaki Sato, Yoshitaka Hishikawa, Taro Funamoto
Summary: This study reveals that Tmem161a is a crucial regulator in bone structure and function. Depletion of Tmem161a leads to thicker and stronger bones in mice.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Yingyu Zhou, Tomohiro Takano, Xuyang Li, Yimei Wang, Rong Wang, Zhangliang Zhu, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Beta-elemene regulates the balance of proinflammatory cytokines in mouse white adipose tissue through MAPK signaling, affecting the imbalance of M1-M2 macrophages and inhibiting the phosphorylation of MAPK pathways. These results suggest that beta-elemene may be a potential therapeutic medicine for macrophage-mediated chronic diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yanbo Wang, Yanling Yu, Wanjing Yu, Xun Bian, Linxia Gong
Summary: IL-35 inhibits cell pyroptosis and reduces asthma injury by suppressing the p38 MAPK pathway.
Article
Fisheries
Kexin Hua, Mingyang Wang, Yishun Jin, Yuan Gao, Rui Luo, Dingren Bi, Rui Zhou, Hui Jin
Summary: This study reveals for the first time the transcription factor Ets2 and the p38 MAPK signaling pathway mediating the expression of pig resistin during H. parasuis stimulation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Physiology
Paulina Villar-Fincheira, Aaron J. Paredes, Tomas Hernandez-Diaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceno, Jorge Mandiola, Nicole Bruneau, Lorena Garcia, Maria Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
Summary: The study aims to evaluate the effects of exercise on plasma IL-6 and sIL-6R levels, and their relationship with vascular remodeling. Results show that post-marathon HT athletes had higher post-race plasma sIL-6R levels than LT athletes, suggesting a possible role of IL-6 in vascular remodeling, with a proposed association between IL-6 and aortic dilation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junjue Chen, Huimin Zhong, Huan Yu, Jun Sun, Bingqiao Shen, Xing Xu, Shouyue Huang, Ping Huang, Yisheng Zhong
Summary: IL-17A plays a significant role in the regulation of retinal immune response and retinal ganglion cell death in glaucoma by promoting retinal microglial activation via p38 MAPK signaling pathway. Suppression of IL-17A contributes to alleviate glaucoma neuropathy.
Article
Biochemistry & Molecular Biology
Joanna Szpotkowska, Kamil Szpotkowski, Jerzy Ciesiolka
Summary: In this study, the spatial folding of the 5'-terminal region of mouse p53 mRNA was proposed using the SAXS method and the RNAComposer program. The RNA-assisted affinity chromatography technique was used to identify proteins that bind to this region. Most of the identified proteins were found to bind to the sites that are accessible for hybridization with complementary oligonucleotides. Additionally, hnRNP K and PCBP2 were found to have high binding affinity to the 5'-terminal region of mouse p53 mRNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Qinrong Wang, Lingling Liu, Xuanjing Gou, Ting Zhang, Yan Zhao, Yuan Xie, Jianjiang Zhou, Ying Liu, Kewei Song
Summary: Silencing XB130 inhibits cell proliferation and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC), and this study investigated the role of the 3'-untranslated region (3'-UTR) in regulating XB130 expression. The results showed that specific regions of the 3'-UTR play important roles in promoting or inhibiting XB130 expression by affecting mRNA stability and translation rate. Additionally, candidate proteins that potentially regulate XB130 expression were identified.
Article
Pharmacology & Pharmacy
Yuan-Chin Lee, Jing-Ting Chiou, Long-Sen Chang
Summary: The study aimed to investigate the cytotoxic effects of the AMPK inhibitor Compound C in chronic myeloid leukemia (CML) cell lines. Compound C induced apoptosis in certain CML cell lines, and its effects were enhanced by the silencing of SIRT3. Autophagy and downregulation of MCL1 were observed in response to Compound C treatment. The study suggests that AMPK inhibition is a promising strategy for improving CML therapy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kohei Morimoto, Ryota Eguchi, Taisuke Kitano, Ken-ichi Otsuguro
Summary: The research demonstrates that in rat spinal cord astrocytes, ß1- and 13-adrenoceptors can promote IL-6 transcription through different signaling pathways (PKC/ERK and cAMP/PKA/CREB), respectively. Additionally, conditioned medium from astrocytes treated with ß2-AR antagonist dexmedetomidine increased IL-6 mRNA in other astrocytes.
Article
Pharmacology & Pharmacy
Panpan Chen, Rong Wang, Fangbin Liu, Shengnan Li, Yanqiu Gu, Lei Wang, Yongfang Yuan
Summary: Schizandrin C from Schisandra chinensis has been found to ameliorate liver fibrosis by regulating lipid metabolism and inflammation through nuclear factor kappa-B and p38/ERK MAPK signaling pathways, making it a potential drug for liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Marcos Paulo Oliveira Almeida, Caroline Martins Mota, Tiago Wilson Patriarca Mineo, Eloisa Amalia Vieira Ferro, Bellisa Freitas Barbosa, Neide Maria Silva
Summary: This study demonstrates the crucial role of HO-1 in human trophoblast cells infected with Toxoplasma gondii, with its inducers inhibiting parasitism and promoting IL-6 production to control infection. The findings highlight the potential of HO-1 as a therapeutic target for Toxoplasma gondii infection during pregnancy.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Mahalia M. McGill, Alyssa R. Richman, Joseph R. Boyd, Bristy Sabikunnahar, Karolyn G. Lahue, Theresa L. Montgomery, Sydney Caldwell, Stella Varnum, Seth Frietze, Dimitry N. Krementsov
Summary: Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system, with higher prevalence in women but more severe symptoms in men. Research has shown that genetic ablation of p38 alpha MAP kinase in myeloid cells has sex-specific protective effects, suggesting that distinct cellular and molecular pathways drive autoimmunity in males and females. This indicates the potential for future sex-specific therapeutic approaches in treating MS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joy E. Kirkpatrick, Keith L. Kirkwood, Patrick M. Woster
Article
Dentistry, Oral Surgery & Medicine
Panos N. Papapanou, Mariano Sanz, Nurcan Buduneli, Thomas Dietrich, Magda Feres, Daniel H. Fine, Thomas F. Flemmig, Raul Garcia, William V. Giannobile, Filippo Graziani, Henry Greenwell, David Herrera, Richard T. Kao, Moritz Kebschull, Denis F. Kinane, Keith L. Kirkwood, Thomas Kocher, Kenneth S. Kornman, Purnima S. Kumar, Bruno G. Loos, Eli Machtei, Huanxin Meng, Andrea Mombelli, Ian Needleman, Steven Offenbacher, Gregory J. Seymour, Ricardo Teles, Maurizio S. Tonetti
JOURNAL OF CLINICAL PERIODONTOLOGY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Ian Needleman, Raul Garcia, Nikos Gkranias, Keith L. Kirkwood, Thomas Kocher, Anna Di Iorio, Federico Moreno, Aviva Petrie
JOURNAL OF CLINICAL PERIODONTOLOGY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Brent Fung, Mahnaz Fatahzadeh, Keith L. Kirkwood, Jeffery Hicks, Sherry R. Timmons
JOURNAL OF DENTAL EDUCATION
(2018)
Article
Dentistry, Oral Surgery & Medicine
H. M. Steinkamp, J. D. Hathaway-Schrader, M. B. Chavez, J. D. Aartun, L. Zhang, T. Jensen, A. Shojaee Bakhtiari, K. L. Helke, D. J. Stumpo, A. V. Alekseyenko, C. M. Novince, P. J. Blackshear, K. L. Kirkwood
JOURNAL OF DENTAL RESEARCH
(2018)
Review
Dentistry, Oral Surgery & Medicine
M. S. Valerio, K. L. Kirkwood
JOURNAL OF DENTAL RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
Lorenzo P. Menzel, Willam Ruddick, Mobaswar H. Chowdhury, David C. Brice, Ryan Clance, Emily Porcelli, Lisa K. Ryan, Jungnam Lee, Ozlem Yilmaz, Keith L. Kirkwood, Laura McMahon, Amy Tran, Gill Diamond
JOURNAL OF PERIODONTAL RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Yanchun Li, Zhongyang Lu, Lixia Zhang, Keith L. Kirkwood, Maria F. Lopes-Virella, Yan Huang
Review
Oncology
Zhenning Li, Fa-yu Liu, Keith L. Kirkwood
Article
Dentistry, Oral Surgery & Medicine
K. H. Kwack, L. Zhang, J. Sohn, V Maglaras, R. Thiyagarajan, K. L. Kirkwood
Summary: The study suggests that expansion of myeloid-derived suppressor cells (MDSCs) in obese mice may contribute to the formation of osteoclasts during periodontitis, leading to increased alveolar bone destruction. This provides a more detailed mechanistic understanding of the interplay between obesity and periodontitis.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yanchun Li, Zhongyang Lu, Lixia Zhang, Cameron L. Kirkwood, Keith L. Kirkwood, Maria F. Lopes-Virella, Yan Huang
Summary: Imipramine, as an inhibitor of aSMase, abolishes the synergy between MetS and periodontitis on alveolar bone loss in animal model and inhibits pro-inflammatory and pro-osteoclastogenic gene expression in macrophages in vitro. This study suggests that aSMase could be a potential therapeutic target for MetS-exacerbated periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jiho Sohn, Lu Li, Lixia Zhang, Rajendra P. Settem, Kiyonobu Honma, Ashu Sharma, Karen L. Falkner, Jan M. Novak, Yijun Sun, Keith L. Kirkwood
Summary: Recent epidemiological studies have shown that inflammatory bowel disease is associated with periodontal disease. This study reveals the mechanism behind P. gingivalis-mediated intestinal inflammation and identifies the alteration in gut microbiota as a key factor in causing intestinal inflammation.
MOLECULAR ORAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Subin Surendran, Usama Aboelkheir, Andrew A. Tu, William J. Magner, S. Lynn Sigurdson, Mihai Merzianu, Wesley L. Hicks, Amritha Suresh, Keith L. Kirkwood, Moni A. Kuriakose
Summary: This study identified T regulatory cells (Treg) infiltrating oral dysplastic lesions, suggesting their association with disease progression. CD8(+) effector T cells and immune checkpoint markers PD-1 and PD-L1 were also associated with oral cancer progression, indicating the presence of an adaptive immune response and T-cell exhaustion.
Article
Dentistry, Oral Surgery & Medicine
Yanchun Li, Zhongyang Lu, Cameron L. Kirkwood, Keith L. Kirkwood, Stephen A. Wank, Ai-Jun Li, Maria F. Lopes-Virella, Yan Huang
Summary: GPR40 deficiency worsens alveolar bone loss and periodontal inflammation in patients with periodontitis and MetS, indicating a beneficial role of GPR40 in MetS-associated periodontitis. Furthermore, GPR40 deficiency or inhibition in macrophages further upregulates proinflammatory and pro-osteoclastogenic genes induced by LPS and palmitic acid, suggesting that GPR40 has anti-inflammatory and anti-osteoclastogenic properties.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
L. Li, Y. Hayashi-Okada, K. L. Falkner, S. Cervi, S. Andrusz, Y. Shimizu, J. J. Zambon, K. L. Kirkwood, R. E. Schifferle, P. I. Diaz
Summary: This study aimed to evaluate the effects of an intensive, at-home, chemical, and mechanical antiplaque regimen as an adjunct to scaling and root planing (SRP) for the treatment of periodontitis. The results showed that intensive antiplaque measures can improve periodontal therapy outcomes, particularly in subjects with diabetes.
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2023)