Article
Biochemistry & Molecular Biology
Alicia Weier, Michael Enders, Philipp Kirchner, Arif Ekici, Marc Bigaud, Christopher Kapitza, Juergen Woerl, Stefanie Kuerten
Summary: Multiple sclerosis is an autoimmune disease of the central nervous system. Siponimod, the only approved drug for secondary progressive MS, acts on the peripheral immune system and does not have pronounced direct neuroprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Roua A. Nouh, Ahmed Kamal, Anwar Abdelnaser
Summary: Multiple sclerosis (MS) is a complex disease characterized by immune system attacks on myelinated axons in the central nervous system. Cannabinoids have shown potential therapeutic effects in controlling MS symptoms, but their dual nature and limitations in treatment should be considered. This review explores the molecular effects of cannabinoids on the endocannabinoid system, factors affecting cannabinoid response, and the positive and adverse effects of cannabinoids in MS.
Review
Cell Biology
Theresa Greiner, Markus Kipp
Summary: Multiple sclerosis initially presents with a relapsing-remitting disease course, then progresses to a secondary progressive stage. In both stages, peripheral immune cells are triggered by CNS-intrinsic stimuli to invade the brain parenchyma.
Article
Biochemistry & Molecular Biology
Kathrin Koch, Maren Lindner, Ann-Katrin Fleck, Marie Liebmann, Melanie Eschborn, Lisa Zondler, Rodrigo Dieguez-Hurtado, Ralf H. Adams, Gerd Meyer zu Hoerste, Alexander Zarbock, Tanja Kuhlmann, Heinz Wiendl, Luisa Klotz
Summary: Pericytes play a crucial role in regulating the blood-brain barrier and influencing immune cell activation in the central nervous system. This study demonstrates that pericytes can directly interact with T cells and induce their activation and proliferation through antigen presentation. The depletion of major histocompatibility complex II in pericytes enhances T cell infiltration in the CNS, although it does not affect the overall disease course.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Carolina Prado, Francisco Osorio-Barrios, Paulina Falcon, Alexandra Espinoza, Juan Jose Saez, Maria Isabel Yuseff, Rodrigo Pacheco
Summary: Recent evidence has shown dopamine as a major regulator of inflammation, with dopaminergic regulation of immune cells playing an important role in inflammatory disorders. The study addressed the role of dopamine receptor D3 in B cells in animal models of multiple sclerosis (MS) and found that selective Drd3 deficiency in B cells abolished disease development in one model while exacerbating disease severity in another, demonstrating a dual role of DRD3 in CNS-autoimmunity.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Rongbo Zhang, Jin Liu, Bin Xu, You Wu, Shunli Liang, Qiang Yuan
Summary: The study investigated the therapeutic effects of cornuside on EAE and its impact on Th17 and Treg cell infiltration. Cornuside showed anti-inflammatory and immunosuppressive effects, alleviating neurological deficits in EAE rats with Th17 cells possibly being one of its therapeutic targets.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Immunology
Hiroshi Horiuchi, Bijay Parajuli, Hiroyasu Komiya, Yuki Ogawa, Shijie Jin, Keita Takahashi, Yasu-Taka Azuma, Fumiaki Tanaka, Akio Suzumura, Hideyuki Takeuchi
Summary: IL-19 deficiency exacerbates multiple sclerosis by promoting Th17 cell infiltration and increasing expression of antigen presentation and Th17 cell differentiation factors. IL-19 suppresses MS pathogenesis by inhibiting macrophage antigen presentation and Th17 cell expansion. Treatment with IL-19 shows significant therapeutic benefits in experimental autoimmune encephalomyelitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hayato Une, Ryo Yamasaki, Satoshi Nagata, Hiroo Yamaguchi, Yuko Nakamuta, Ulfa Camelia Indiasari, Yiwen Cui, Koji Shinoda, Katsuhisa Masaki, Magdalena Goetz, Jun-ichi Kira
Summary: By knocking out the Cx43 gene in astroglia, EAE clinical symptoms can be alleviated, reducing inflammation cell infiltration and demyelination in the spinal cord, meanwhile promoting anti-inflammatory gene expression and inhibiting proinflammatory gene expression.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Immunology
Judith Derdelinckx, Patrick Cras, Zwi N. Berneman, Nathalie Cools
Summary: Antigen-specific therapy for multiple sclerosis aims to induce tolerance to myelin-derived antigens for more effective treatment, but faces challenges from clinical trials and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Yun Xiao, Jing Tian, Wen-Cheng Wu, Yu-Han Gao, Yu-Xin Guo, Sheng-Jiao Song, Rui Gao, Li-Bin Wang, Xiao-Yu Wu, Yuan Zhang, Xing Li
Summary: The lack of targeted and high-efficiency drug delivery to the central nervous system (CNS) nidus is a major problem in treating demyelinating diseases. This study developed a novel therapeutic system using engineered extracellular vesicles (EVs) from neural stem cells (NSCs) with high expressed ligand PDGF-A (EVPs) for local delivery targeting oligodendrocyte lineage. Experimental results demonstrated that systemic injection of EVPs + T3, as compared to EVPs or T3 alone, significantly alleviated disease progression, enhanced oligodendrocyte survival, inhibited myelin damage, and promoted myelin regeneration in mice with experimental autoimmune encephalomyelitis.
BIOACTIVE MATERIALS
(2022)
Review
Medicine, Research & Experimental
Danning Wang, Shaodi Guan, Pei Lu, Yali Li, Hui Xu
Summary: Growing evidence indicates the involvement of extracellular vesicles (EVs) in the communication between the central nervous system (CNS) and peripheral organs. EVs, serving as innovative information transport systems, can transport various bioactive substances and cross the blood-brain barrier. This review explores the mechanisms by which EVs contribute to neurodegenerative diseases, stroke, and trauma, and highlights their potential for targeted drug delivery.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Daniel Schiffmann, Victoria Lampkemeyer, Maren Lindner, Ann-Katrin Fleck, Kathrin Koch, Melanie Eschborn, Marie Liebmann, Jan-Kolja Strecker, Jens Minnerup, Heinz Wiendl, Luisa Klotz
Summary: This study investigated the impact of endurance exercise on established secondary progressive MS and found that exercise can attenuate the disease course, potentially through modulation of the innate immune compartment. Further studies are warranted to validate these findings and assess the potential of this lifestyle intervention as a complementary therapeutic strategy in patients with secondary progressive MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Jacqueline M. Orian, Claretta S. D'Souza, Pece Kocovski, Guy Krippner, Matthew W. Hale, Xiaowei Wang, Karlheinz Peter
Summary: Platelets play important roles not only in thrombosis and hemostasis, but also in inflammatory and immune reactions. They are central to immune responses and may serve as key mediators in autoimmune disorders, such as their association with multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Valeria Ramaglia, Olga Rojas, Ikbel Naouar, Jennifer L. Gommerman
Summary: Multiple sclerosis is a chronic disease characterized by the invasion of immune cells into the central nervous system, causing demyelination of axons and subsequent physical and cognitive disability. Immunologists are interested in MS as it provides a case study for how immune cells interact with CNS barriers and specialized tissue cells. The review describes the infiltration of immune cells into the CNS, their interactions with glial cells in different lesions, and the impact of compartmentalized immune cells on disease progression.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Article
Surgery
Shoichi Kageyama, Hirofumi Hirao, Kojiro Nakamura, Bibo Ke, Min Zhang, Takahiro Ito, Antony Aziz, Damla Oncel, Fady M. Kaldas, Ronald W. Busuttil, Rebecca A. Sosa, Elaine F. Reed, Jesus A. Araujo, Jerzy W. Kupiec-Weglinski
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Meeting Abstract
Immunology
Fang Li, Nicole Valenzuela, Rebecca Sosa, Enrique Rozengurt, Elaine F. Reed
Article
Surgery
Rebecca A. Sosa, Maura Rossetti, Bita Naini, Victoria M. Groysberg, Fady M. Kaldas, Ronald W. Busuttil, Yu-Ling Chang, David W. Gjertson, Jerzy W. Kupiec-Weglinski, Elaine F. Reed
Article
Surgery
Xuedong Wei, Nicole M. Valenzuela, Maura Rossetti, Rebecca A. Sosa, Jessica Nevarez-Mejia, Gregory A. Fishbein, Arend Mulder, Jayeeta Dhar, Karen S. Keslar, William M. Baldwin, Robert L. Fairchild, Jianquan Hou, Elaine F. Reed
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Gastroenterology & Hepatology
Rebecca A. Sosa, Allyson Q. Terry, Fady M. Kaldas, Yi-Ping Jin, Maura Rossetti, Takahiro Ito, Fang Li, Richard S. Ahn, Bita V. Naini, Victoria M. Groysberg, Ying Zheng, Antony Aziz, Jessica Nevarez-Mejia, Ali Zarrinpar, Ronald W. Busuttil, David W. Gjertson, Jerzy W. Kupiec-Weglinski, Elaine F. Reed
Summary: The study identified disulfide-HMGB1 as a mechanistic biomarker and therapeutic target for minimizing sterile inflammation during human liver ischemia-reperfusion injury.
Article
Medicine, Research & Experimental
Kojiro Nakamura, Shoichi Kageyama, Fady M. Kaldas, Hirofumi Hirao, Takahiro Ito, Kentaro Kadono, Kenneth J. Dery, Hidenobu Kojima, David W. Gjertson, Rebecca A. Sosa, Maciej Kujawski, Ronald W. Busuttil, Elaine F. Reed, Jerzy W. Kupiec-Weglinski
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Review
Cell Biology
Carol Chase Huizar, Itay Raphael, Thomas G. Forsthuber
CELLULAR IMMUNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Ming Ni, Jing Zhang, Rebecca Sosa, Hanwen Zhang, Han Wang, Dan Jin, Kaitlyn Crowley, Bita Naini, F. Elaine Reed, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski, Xuehao Wang, Yuan Zhai
Summary: TIM-4 is critical for the homeostatic function of Kupffer cells in both the activation and resolution of liver ischemia reperfusion injury through efferocytosis.
Article
Cell Biology
Carol Chase Huizar, Niannian Ji, Robert Reddick, Gary R. Ostroff, Thomas G. Forsthuber
Summary: The use of beta-1,3-D-glucan particles has been shown to effectively induce experimental autoimmune encephalomyelitis (EAE) in mice without causing strong injection site tissue reactions, offering a potential alternative method for inducing EAE. This method resulted in comparable disease severity and immune responses to traditional methods, but with reduced inflammation.
CELLULAR IMMUNOLOGY
(2021)
Article
Immunology
Yi-Ping Jin, Jessica Nevarez-Mejia, Allyson Q. Terry, Rebecca A. Sosa, Sebastiaan Heidt, Nicole M. Valenzuela, Enrique Rozengurt, Elaine F. Reed
Summary: Donor-specific HLA antibodies stimulate the formation of complexes between TLR4 and HLA I on ECs, leading to EC activation and recruitment of monocytes. Knockdown of TLR4 or MyD88 inhibits P-selectin expression, von Willebrand factor release, and monocyte recruitment on ECs stimulated by HLA I antibodies.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Transplantation
Rebecca A. Sosa, Allyson Q. Terry, Takahiro Ito, Bita V. Naini, Ying Zheng, Harry Pickering, Jessica Nevarez-Mejia, Ronald W. Busuttil, David W. Gjertson, Jerzy W. Kupiec-Weglinski, Elaine F. Reed, Fady M. Kaldas
Summary: Hispanic patients undergoing liver transplantation for NASH have worse outcomes, particularly among females. The underlying immune mechanisms include increased inflammation and apoptosis.
TRANSPLANTATION DIRECT
(2023)
Article
Surgery
Sahar Salehi, Rebecca A. Sosa, Yi-Ping Jin, Shoichi Kageyama, Michael C. Fishbein, Enrique Rozengurt, Jerzy W. Kupiec-Weglinski, Elaine F. Reed
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Meeting Abstract
Surgery
R. Sosa, J. Nevarez-Mejia, M. Rossetti, A. Zarrinpar, F. Kaldas, C. Lassman, B. Naini, N. Datta, R. Busuttil, D. Gjertson, J. Kupiec-Weglinski, E. Reed
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Meeting Abstract
Surgery
K. Nakamura, S. Kageyama, X. Li, A. Aziz, R. Sosa, E. Reed, F. Kaldas, R. Busuttil, J. Kupiec-Weglinski
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Meeting Abstract
Surgery
K. Nakamura, S. Kageyama, S. Yue, A. Aziz, T. Ito, D. Oncel, B. Ke, R. Sosa, E. Reed, F. Kaldas, R. Busuttil, J. Kupiec-Weglinski
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)