Letter
Plant Sciences
Philippe Fuchs, Elisenda Feixes-Prats, Paulo Arruda, Elias Feitosa-Araujo, Alisdair R. Fernie, Christopher Grefen, Sophie Lichtenauer, Nicole Linka, Ivan de Godoy Maia, Andreas J. Meyer, Soeren Schilasky, Lee J. Sweetlove, Stefanie Wege, Andreas P. M. Weber, A. Harvey Millar, Olivier Keech, Igor Florez-Sarasa, Pedro Barreto, Markus Schwarzlaender
Summary: UCP2 is localized to the Golgi, unlike its close homolog UCP1, which is abundant in the mitochondria.
Article
Endocrinology & Metabolism
Jing Luo, Yao Wang, Elizabeth Gilbert, Dongmin Liu
Summary: Deletion of GPR30 protects female mice from HFD-induced obesity by regulating energy metabolism and adipocyte differentiation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Plant Sciences
Jiyang Wang, Guojuan Xu, Yuese Ning, Xuli Wang, Guo-Liang Wang
Summary: Mitochondria play important roles in plant immunity by altering metabolism, producing reactive species, and triggering programmed cell death to defend against pathogen infection. Additionally, mitochondria coordinate with other organelles to integrate and amplify immune signals.
TRENDS IN PLANT SCIENCE
(2022)
Review
Plant Sciences
Vasily N. Popov, Mikhail Y. Syromyatnikov, Alisdair R. Fernie, Subhra Chakraborty, Kapuganti Jagadis Gupta, Abir U. Igamberdiev
Summary: Plant mitochondrial respiration involves various alternative pathways that are uncoupled from energy production, contributing to ROS and NO metabolism. These pathways play a crucial role in maintaining mitochondrial functions and rapid adaptation of plants to changing environmental factors.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Taylor, Agnieszka Piasecka, Arkadiusz Kajdasz, Aleksandra Brzek, Micaela Polay Espinoza, Cyril F. Bourgeois, Artur Jankowski, Malgorzata Borowiak, Katarzyna D. Raczynska, Lukasz J. Sznajder, Krzysztof Sobczak
Summary: This study aims to elucidate the mechanism of muscleblind-like splicing regulators (MBNLs) in alternative splicing (AS) processes. The findings indicate that DEAD-box (DDX) RNA helicases DDX5 and DDX17 play an important role in MBNL-dependent AS regulation. The helicases modulate MBNL splicing activity through changes in the ratio of MBNL splicing isoforms and accessibility of MBNL-binding sites. These findings contribute to a deeper understanding of the interdependencies between RNA-binding proteins and their implications in developmental homeostasis and pathological states.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Mingyao Peng, Shanqi Zhang, Kunhong Zhao, Yuguo Zheng, Xiangyang Li
Summary: This study shows that novel compounds containing the structure of phthalimide have antibacterial, insecticidal, and herbicidal activities, and can bind to plant hormone receptors, playing important regulatory roles.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Aprajita Kumari, Vemula Chandra Kaladhar, Nidhi Yadav, Pooja Singh, Kishorekumar Reddy, Kapuganti Jagadis Gupta
Summary: The location of NO production in mitochondrial cytochrome c oxidase and its role in mitochondrial biogenesis were investigated in Arabidopsis seedlings under osmotic stress and recovery. Osmotic stress reduced growth and mitochondrial number while increasing NO production. Nitrite application stimulated NO production and mitochondrial number in a NO-deficient mutant. COX6b(-)3 and COA6-L subunits were induced during osmotic stress and mutants impaired in these subunits showed reduced NO production and mitochondrial biogenesis. The COX6b-3 and COA6-L subunits interacted with a VQ27 motif-containing protein in the presence of NO, and a vq27 mutant displayed impaired mitochondrial biogenesis.
PLANT CELL AND ENVIRONMENT
(2023)
Review
Plant Sciences
Isabelle Faria Matos, Luis Miguel Mazorra Morales, Diederson Bortolini Santana, Glaucia Michelle Cosme Silva, Mara Menezes de Assis Gomes, Ricardo Antonio Ayub, Jose Helio Costa, Jurandi Goncalves de Oliveira
Summary: Vitamin C is essential for metabolism, and humans rely on plants as a source of vitamin C. The last step of the vitamin C synthesis pathway in plants is linked to the respiratory chain of mitochondria and catalyzed by l-galactono-1,4-lactone dehydrogenase (l-GalLDH). This enzyme can introduce electrons into the respiratory chain and bypass the phosphorylating Complex III. This review explores the potential changes in respiratory function and physiological alterations related to low vitamin C in plants.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Immunology
IkRak Jung, Becky Tu-Sekine, Sunghee Jin, Frederick Anokye-Danso, Rexford S. Ahima, Todd T. Brown, Sangwon F. Kim
Summary: The study found that DTG targets UCP1 and mitochondrial functions in brown and beige adipocytes, disrupting thermogenic functions in preclinical models.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Plant Sciences
Yanmin Zou, Zeyang Liu, Jiaojiao Bai, Yuanyuan Zhou, Dongping Lu
Summary: The imbalance in the mitochondrial proteome leads to mitochondrial proteotoxic stresses, and the mechanisms of UPRmt signaling in plants are less understood. This study reveals that the DNA intercalating agent EtBr triggers UPRmt and activates ABA signaling in Arabidopsis thaliana.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Sanja Skulj, Zlatko Brkljaca, Jurgen Kreiter, Elena E. Pohl, Mario Vazdar
Summary: Molecular dynamics simulations of uncoupling proteins present a challenge due to the lack of available structural data. In this study, a combination of homology modelling and MD simulations of UCP2 revealed a structure impermeable to water. Additionally, results from conductance measurements in model membranes suggest that the UCP2 structure modeled from ANT protein possesses key functional elements related to proton transport.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Junyan Zhu, Xiaomei Yan, Shengrui Liu, Xiaobo Xia, Yanlin An, Qingshan Xu, Shiqi Zhao, Lu Liu, Rui Guo, Zhaoliang Zhang, De-Yu Xie, Chaoling Wei
Summary: By integrating metabolomics and transcriptomics, this study reveals that alternative splicing variants of the CsJAZ1 gene coordinately regulate the biosynthesis of flavan-3-ols in the tea plant, providing a better understanding of the JA-mediated flavan-3-ol biosynthesis.
Article
Biochemistry & Molecular Biology
Woo Yong Park, Gahee Song, Ja Yeon Park, Kwan-Il Kim, Kwang Seok Ahn, Hyun Jeong Kwak, Jungtae Leem, Jae-Young Um, Jinbong Park
Summary: The extract of Gardenia jasminoides fruit induces thermogenic action by activating mitochondrial function via PPAR gamma activation, suggesting potential as an anti-obesity agent with a novel mechanism involving thermogenic action in white adipocytes.
Review
Biochemistry & Molecular Biology
David G. Nicholls
Summary: This review examines the mechanisms underlying non-shivering thermogenesis in brown adipose tissue mediated by UCP1, emphasizing the experimental evidence and physiological constraints. It also discusses the nature of endogenous proton leak and evaluates the troubled history of putative novel uncoupling proteins UCP2 and UCP3.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2021)
Review
Plant Sciences
Norbert Andrasi, Aladar Pettko-Szandtner, Laszlo Szabados
Summary: Plant heat shock factors (HSFs) are encoded by large gene families and are involved in responses to high temperatures and various abiotic stresses. They are regulated primarily at the transcript level, with alternative splicing and post-translational modifications providing additional variability. Plant HSFs participate in a complex network of protein-protein interactions and play crucial roles in transcriptional control.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)