Article
Biochemistry & Molecular Biology
Tyler Cobb, Deena Damschroder, Robert Wessells
Summary: This study investigates the roles of Sestrin and Spargel in the chill coma response in Drosophila melanogaster, finding that they are important for recovery time independent of their role in exercise.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Cleopatra A. Moraiti, Eleni Verykouki, Nikos T. Papadopoulos
Summary: The study investigated the basal chill tolerance of the Mediterranean fruit fly across different latitudes and found that the climatic variability, particularly in terms of temperature and precipitation, has an impact on the fly's cold tolerance. The results revealed latitudinal trends in chill coma recovery time and indicated the combined effects of latitude and macroclimatic conditions. Overall, the study suggests that local climatic variability drives the evolutionary patterns of basal chill tolerance in the fruit fly.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Wu Ling-Yun, Yan Jun, Huang Zhi-wu, Wan Yan-Hui, Zhu Wei-Min
Summary: Seed priming, particularly using the solid matrix priming (SMP) method, effectively enhances seed germination and early seedling growth of cauliflower and broccoli under suboptimal temperature conditions. SMP improves antioxidant enzyme activities, seed germination vigor, and emergence of the seeds during the early spring season.
Article
Agricultural Engineering
Hutao Wang, Caiye Hu, Yi Wang, Chunji Jin, Zonglian She, Liang Guo
Summary: This study investigated the effects of SDZ on the growth, photosynthesis, cellular damage, antioxidant capacity, and intracellular biochemical components of Chlorella pyrenoidosa. The results showed that SDZ inhibited the growth of C. pyrenoidosa but had little impact on photosynthesis. SDZ stress also increased the lipid and carbohydrate content of C. pyrenoidosa, improving its biodiesel quality.
BIORESOURCE TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Cecilia Ramiro Talarico, Rafaella Almeida Lima Nunes, Gabriela Avila Fernandes Silva, Larissa Bastos Eloy da Costa, Marcella Regina Cardoso, Sergio Carlos Barros Esteves, Luis Otavio Zanatta Sarian, Luiz Carlos Zeferino, Lara Termini
Summary: High SOD2 expression is strongly associated with recurrence, distant recurrence, and death in patients with stage IIIB squamous cell cervical carcinoma. Multivariate analysis revealed a threefold increased risk of recurrence and death in patients with high SOD2 expression compared to those with low expression. Patients with high SOD2 expression had shorter disease-free and overall survival times.
Article
Plant Sciences
Lifeng Chen, Hongzhen Jiang, Guoqiang Xing, Bing Guan, Yang Yang, Anwar Ahmed, Xiaodong Ma
Summary: Adjunct therapies with YB and XNJ can improve postoperative recovery and clinical prognosis in patients with moderate-to-severe TBI, possibly through divergent regulation of S100B and SOD pathways.
Article
Cell Biology
Kira L. Tomlinson, Sebastian A. Riquelme, Swikrity Upadhyay Baskota, Marija Drikic, Ian R. Monk, Timothy P. Stinear, Ian A. Lewis, Alice S. Prince
Summary: Neutrophils play a critical role in defending against Staphylococcus aureus infection. However, S. aureus can still evade immune clearance even in the presence of a strong neutrophil response. This study reveals that S. aureus impairs neutrophil function by inducing the production of the anti-inflammatory metabolite itaconate. Itaconate inhibits neutrophil glycolysis and oxidative burst, leading to compromised bacterial killing. This evasion mechanism involves targeting neutrophil metabolism and inducing the production of itaconate.
Article
Multidisciplinary Sciences
Jeremy W. Linsley, Drew A. Linsley, Josh Lamstein, Gennadi Ryan, Kevan Shah, Nicholas A. Castello, Viral Oza, Jaslin Kalra, Shijie Wang, Zachary Tokuno, Ashkan Javaherian, Thomas Serre, Steven Finkbeiner
Summary: Optimized convolutional neural networks (BO-CNNs) improve the detection accuracy and speed of cell death, while also revealing a previously unnoticed intranuclear cell signal that reliably indicates death. These models are essential for analyzing live microscopy and interpreting high-throughput experiments.
Article
Chemistry, Multidisciplinary
Premkumar Jayaraj, Priyanka Sarkar, Sreyoshi Routh, Chaitanya Sarathe, Rajagopal Desikan, Kavitha Thirumurugan
Summary: This study synthesized lipoic acid-sesamol conjugate (LSC) using phytonutrients and analyzed its chemical structure and biological properties. The experiments showed that lower concentrations of LSC increased the survival rate of fruit flies and provided longevity under heat shock, oxidative stress, and starvation stress. This discovery has great significance in the field of anti-aging research.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Eira Choudhary, Rishabh Sharma, Pramila Pal, Nisheeth Agarwal
Summary: This study examined the adaptive mechanisms of Mycobacterium tuberculosis (Mtb) under physiological stresses and identified protein changes in response to acid, diamide, and H2O2 treatments. The findings highlight the importance of proteomics in understanding the complex adjustments made by Mtb during infection.
Article
Cell & Tissue Engineering
Bradley W. Ellis, Dmitry O. Traktuev, Stephanie Merfeld-Clauss, Uryan Isik Can, Meijing Wang, Ray Bergeron, Pinar Zorlutuna, Keith L. March
Summary: Heart transplantation is a life-saving therapy for end-stage organ failure, but organ deterioration during transportation limits the number of hearts available for transplantation. Studies show that adipose-derived stem/stromal cell secretome (ASC-S) can ameliorate organ damage and increase the pool of hearts acceptable for transplantation.
Review
Biochemistry & Molecular Biology
Flavio R. Palma, Benjamin N. Gantner, Marcelo J. Sakiyama, Cezar Kayzuka, Sanjeev Shukla, Riccardo Lacchini, Brian Cunniff, Marcelo G. Bonini
Summary: In eukaryotic cells, mitochondria are traditionally viewed as the primary organelles responsible for ATP generation under normoxic conditions. However, recent studies have shown that mitochondrial ROS play important signaling functions in cellular adaptation and stress resistance. Contrary to previous beliefs, ROS production is not merely a by-product of dysfunctional mitochondria, but an essential component in cellular adaptation triggered by important stressors.
Article
Pharmacology & Pharmacy
Jiancheng Xu, Jing Ji, Zhan Wang, Tao Xu
Summary: The study found that minocycline can promote the recovery of motor function after spinal cord injury in rats. The possible mechanism of action includes inhibiting local free radical generation, reducing lipid peroxidation and glial fibrillary acidic protein expression, and promoting the synthesis of endogenous brain-derived neurotrophic factor.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shunlong Meng, Xi Chen, Chao Song, Limin Fan, Liping Qiu, Yao Zheng, Jiazhang Chen, Pao Xu
Summary: The study found that lower concentrations of methomyl had no effect on antioxidant levels in the testis of Nile tilapia, while higher concentrations significantly influenced these antioxidants. Recovery tests showed that oxidative damage caused by lower concentrations of methomyl was reversible, whereas damage from higher concentrations was irreversible within 18 days.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Arvin Behzadi, Fani Pujol-Calderon, Anton E. Tjust, Anna Wuolikainen, Kina Hoglund, Karin Forsberg, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Peter Munch Andersen
Summary: Elevated levels of CSF NFL, CSF pNFH, and plasma NFL are significantly associated with ALS, providing diagnostic value in differentiating ALS from other neurological diseases. Plasma NFL levels can help differentiate between clinical and genetic subgroups of ALS. Survival rate is negatively correlated with all three biomarkers.
SCIENTIFIC REPORTS
(2021)
Article
Entomology
Luciana Mercedes Pujol-Lereis, Natalia Soledad Fagali, Alejandro Rabossi, Angel Catala, Luis Alberto Quesada-Allue
JOURNAL OF INSECT PHYSIOLOGY
(2016)
Article
Oncology
Gabriela A. Pizzurro, Florencia P. Madorsky Rowdo, Luciana M. Pujol-Lereis, Luis A. Quesada-Allue, Andrea M. Copati, Maria P. Roberti, Jean-Luc Teillaud, Estrella M. Levy, Maria M. Barrio, Jose Mordoh
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2013)
Article
Geriatrics & Gerontology
Luciana Mercedes Pujol-Lereis, Alejandro Rabossi, Luis Alberto Quesada-Allue
EXPERIMENTAL GERONTOLOGY
(2012)
Article
Biochemistry & Molecular Biology
J. Berni, A. Rabossi, L. M. Pujol-Lereis, D. S. Tolmasky, L. A. Quesada-Allue
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Luciana Mercedes Pujol-Lereis, Ana Massaldi, Alejandro Rabossi, Luis Alberto Quesada-Allue
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2010)
Article
Multidisciplinary Sciences
Luciana M. Pujol-Lereis, Gerhard Liebisch, Tina Schick, Yuchen Lin, Felix Grassmann, Koji Uchida, Peter F. Zipfel, Sascha Fauser, Christine Skerka, Bernhard H. F. Weber
Review
Biochemistry & Molecular Biology
Luciana M. Pujol-Lereis
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Isabelle Steymans, Luciana M. Pujol-Lereis, Bjorn Brembs, E. Axel Gorostiza
Summary: Our unique character traits define our behavior consistency and individuality, which are not robotic or machine-like repetitive behaviors. Both humans and animals combine personality traits with spontaneity to produce adaptive behavior. In the study of fruit flies, the interaction between individuality and spontaneity explains why group averages are poor predictors of individual choices, even for seemingly stereotype behaviors.