Article
Chemistry, Inorganic & Nuclear
Kakoli Malakar, Winaki P. Sohtun, Venkatesan Srinivasan, Marappan Velusamy
Summary: A binuclear copper(I) complex was synthesized and characterized. The binding interaction between the complex and BSA was studied using absorption and fluorescence spectroscopy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Swarup Kumar Tarai, Saikat Mandal, Arup Tarai, Ipsita Som, Angana Pan, Arka Bagchi, Arunima Biswas, Sankar Ch. Moi
Summary: The bidentate donor Schiff base HL was synthesized for the synthesis of CuL2 complex, which showed important structural features characterized by single crystal X-ray diffraction and spectroscopic methods. DFT/TD-DFT studies were performed to evaluate the structure optimization, electronic spectroscopy data, and binding interactions with biomolecules. The Cu(II) complex showed anticancer activity and less toxicity compared to cisplatin and oxaliplatin, and the mechanism of cell death was assessed via apoptosis or necrosis.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Sivaswamy Kanchanadevi, Frank R. Fronczek, Charles Immanuel David, Raju Nandhakumar, Viswanathan Mahalingam
Summary: Two mononuclear complexes of Co(II) and Ni(II) and a binuclear copper(II) complex were synthesized and characterized for their biological activities, including DNA and protein-binding, antioxidant and anticancer activity. The interaction with DNA and protein, as well as radical scavenging ability, of the complexes were studied, and their cytotoxicity towards human cancer cell lines was tested.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Physical
Shunmugasundaram Gurusamy, Kumar Krishnaveni, Murugesan Sankarganesh, Veerasamy Sathish, Pounraj Thanasekaran, Alagarsamy Mathavan
Summary: A novel naphthalene-based Schiff-base ligand (NNP) was synthesized and characterized, showing selective colorimetric response towards Co2+ and Cu2+ cations, high antioxidant effect, and strong binding affinity with DNA and BSA. The results suggest NNP's potential for biological and environmental monitoring studies as well as the design of new multiple target detection and binding sensors.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Murugesan Sankarganesh, Paul Raj Adwin Jose, Jeyaraj Dhaveethu Raja, Rajadurai Vijay Solomon, Clarence Dorothy Sheela, Shunmugasundaram Gurusamy
Summary: A new octahedral platinum complex [PtLCl4] of Schiff base ligand containing pyrimidine and morpholine skeleton was synthesized and characterized. The compound exhibited interaction with DNA and BSA through electrostatic interactions and static quenching, respectively. The platinum complex showed promising anticancer activity against various cancer cell lines, while also demonstrating good radical scavenging and antimicrobial abilities.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Physical
Jayanthi Eswaran, Anusuya Mariappan, Nagaveni Arumugham, Theetharappan Murugan, Nattamai Sp Bhuvanesh, Neelakandan Mallanpillai Anathakrishnan, Santhanaraj Daniel, Rajakumar Kanthapazham
Summary: In this study, a series of ruthenium complexes were synthesized and investigated for their interaction with biomolecules DNA and protein, as well as their cytotoxicity against human breast cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Jianfang Dong, Qiong Guo, Peiran Zhao, Lei Gao, Buqin Jing, Lianzhi Li
Summary: The interactions between two mixed-ligand oxovanadium(IV) complexes and bovine serum albumin were studied. The results showed that complex 2 has a better affinity for bovine serum albumin and both complexes have similar binding modes located within subdomain IIA of BSA.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Hakan Sahal, Samet Oz, Suat Tekin, Erdal Canpolat
Summary: Five new sulfonamide-based Schiff base compounds were synthesized and characterized. The compounds exhibited cytotoxic effects against cancer cells, leading to cell death through DNA damage.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Si-Yuan Chen, Xiao-Hong Jiang, Rui-Xue Liu, Yao Huang, Wen-Ying Shen, Yan-Hua Jiang, Ke-Bin Huang, Yan-Cheng Liu
Summary: The copper(II) and zinc(II) complexes of three new Schiff base ligands exhibit higher anti-proliferation activities against tumor cell lines but without obvious cytotoxicity on normal liver cell lines. Complex 2 can induce cell cycle arrest and cell apoptosis through the mitochondria-related apoptotic pathway. DNA binding studies suggest that the complexes likely bind with DNA in an intercalative mode.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Elahe Keshavarzian, Zahra Asadi, Monika Kucerakova, Michal Dusek, Banafsheh Rastegari
Summary: In this study, two new mononuclear CoIII and NiII complexes were synthesized and their bio-interactions, antineoplastic ability, and basal cell toxicity were investigated. The results showed that these complexes exhibited static mechanism of interaction with proteins and DNA mainly through hydrophobic forces. Docking studies and experimental data revealed that the NiII complex had stronger intercalation binding with DNA compared to the CoIII complex.
Article
Chemistry, Applied
Prasun Acharya, Ribhu Maity, Arun Kuila, Tithi Maity, Swapan Maity, Nayim Sepay, Bidhan Chandra Samanta
Summary: In this study, a new Cu(II) complex was synthesized and its interactions with DNA and BSA protein were investigated using experimental and theoretical methods. The experimental results demonstrated the strong binding ability of the complex to CT-DNA and BSA protein, which was supported by molecular docking analysis. Additionally, the complex showed potential as a biomaterial for transplantation.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Shuxian Yu, Chuan Li, Shuhua Fan, Juan Wang, Lu Liang, Min Hong
Summary: Three new organotin(IV) complexes have been synthesized by reacting organotin(IV) chlorides with Schiff base carboxylic acid ligand. The complexes were characterized and evaluated for their structural features and cytotoxicities. The results showed that the di-n-butyltin(IV) and triphenyltin(IV) complexes exhibited higher cytotoxicities, possibly due to the generation of intracellular reactive oxygen species (ROS).
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Polymer Science
Saraswathi Kothandan, Sheela Angappan
Summary: The study synthesized and characterized two previously unreported dioxovanadium(V) complexes, showing good DNA/BSA binding ability and cytotoxic effects against cervical cancer cells. The complexes preferentially bind to the DNA groove with increasing concentration, as observed through hyperchromic effects.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2021)
Article
Chemistry, Physical
Ola A. El-Gammal, Ashraf A. El-Bindary, Farid Sh Mohamed, Ghada N. Rezk, Mohamed A. El-Bindary
Summary: This study investigates the properties of a novel Schiff base and its complexes with Co(II), Ni(II), and Cu(II) metals using various analysis methods. The research covers structural characterization, thermodynamic properties, DNA binding, antioxidant activity, and antibacterial action. The potential of the compound in combating COVID-19 and prostate cancer is evaluated through its interaction with the SARS-CoV-2 main protease.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Multidisciplinary Sciences
Ghada N. Rezk, Ola A. El -Gammal, Salhah H. Alrefaee, Ismail Althagafi, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: A hydrazone ligand was successfully created by combining hydrazide with 2-Acetylpyridine. Copper (II) hydrazone complexes were synthesized using various copper (II) salts and studied using analytical techniques. The complexes exhibited tridentate behavior and octahedral geometries. Their properties were analyzed through computational calculations and experimental assays, revealing potential antimicrobial and antioxidant effects.
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)