期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 141, 期 -, 页码 94-102出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2014.08.013
关键词
Gold complexes; N-heterocyclic dicarbenes; Antiproliferative effects; Dinuclear complexes; Metallopharmaceuticals; CuAAC
资金
- La Ligue contre le Cancer - Region Grand Est, France [CCIR-GE]
New dinuclear di(N-heterocyclic carbene) silver(I), gold(I) and gold(III) complexes have been synthesised and their antiproliferative effects towards various cancer cell lines have been screened. The di(N-heterocyclic carbene) ligands have a propylene linker between the carbene moieties and the imidazole backbone has been functionalised with a 1-benzyl- or 1-PEG-1,2,3-triazole ring (PEG = poly(ethylene glycol)) via a CuAAC (copper azido alkyne cycloaddition) reaction. The resulting gold(I) and gold(III) complexes display an antiproliferative activity superior to that of the unfunctionalised pristine complexes together with a higher selectivity towards cancerous cells with respect to healthy cells. (C) 2014 Elsevier Inc. All rights reserved.
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