Article
Chemistry, Multidisciplinary
Zhi Liu, Gregory A. Simchick, Jing Qiao, Morgan M. Ashcraft, Shuolin Cui, Tamas Nagy, Qun Zhao, May P. Xiong
Summary: A nanochelator system utilizing the physiological environment of iron overload was developed to improve iron elimination and pharmacokinetic properties in mice, showing promising results for iron chelation therapy with no adverse effects observed in toxicity studies. This ROS-responsive nanochelator design could be a safe alternative for effectively removing iron chelates from the body in iron chelation therapy regimens requiring repeated dosing.
Article
Biotechnology & Applied Microbiology
Zhuobin Xu, Yufei Zhu, Mengke Xie, Kankan Liu, Liangliang Cai, Huihui Wang, Dandan Li, Hao Chen, Lizeng Gao
Summary: This study synthesized mackinawite nanozymes (GFeSNs) from glutathione and iron ions, and found that GFeSNs have broad-spectrum antioxidant properties and can significantly improve the treatment outcomes of acute kidney injury (AKI) by scavenging reactive oxygen species (ROS).
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Chemistry, Analytical
Marialaura Marchetti, Luca Ronda, Monica Cozzi, Stefano Bettati, Stefano Bruno
Summary: This review provides an overview of genetically encoded biosensors for real-time measurements of intracellular oxygen and reactive oxygen species (ROS) concentrations. Oxygen sensing relies on oxygen-dependent mechanisms and direct binding, while ROS sensing involves ROS-induced chemical reactions and conformational changes. Real-time measurement of oxygen and ROS concentrations is critical for investigating physiological and pathological conditions.
Article
Plant Sciences
Huihui Zhang, Yunpeng Liu, Gengwei Wu, Xiaoyan Dong, Qin Xiong, Lin Chen, Zhihui Xu, Haichao Feng, Ruifu Zhang
Summary: This study demonstrates that Bacillus velezensis SQR9 can enhance root colonization efficiency by tolerating plant-derived oxidative stress, contributing to plant growth promotion.
PLANT CELL AND ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Pravin T. Goud, David Bai, Husam M. Abu-Soud
Summary: Severe COVID-19 patients may experience overwhelming inflammation and cytokine storms that activate reactive oxygen species, leading to nitric oxide consumption and worsening hypoxia due to decreased oxygen supply, resulting in cellular and tissue damage. These injuries further induce vasoconstriction, hypoxemia, and precipitous clinical deterioration in patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Engineering, Environmental
Ruixia Han, Jitao Lv, Suhuan Zhang, Shuzhen Zhang
Summary: The study found that surface structure significantly affects the microbial dissimilatory iron reduction and aerobic oxidation processes, with HNP producing more Fe(II) than HNR during reduction, and HNR showing higher ROS production efficiency during oxidation.
Review
Plant Sciences
Kosuke Mase, Hironaka Tsukagoshi
Summary: Plant development is highly regulated by plant hormones and signaling pathways, with reactive oxygen species (ROS) playing an essential role as signaling molecules. ROS accumulation in plant roots helps maintain cell proliferation and differentiation balance for proper root growth. However, disruption of this balance affects how plants respond to environmental changes. The crosstalk between ROS and hormone signals, mediated by transcription factors, is crucial for regulating root growth and immune responses in plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Samuel A. McInturf, Mather A. Khan, Arun Gokul, Norma A. Castro-Guerrero, Ricarda Hohner, Jiamei Li, Henri-Baptiste Marjault, Yosef Fichman, Hans-Henning Kunz, Fiona L. Goggin, Marshall Keyster, Rachel Nechushtai, Ron Mittler, David G. Mendoza-Cozatl
Summary: The study reveals that both iron deficiency and cadmium exposure induce similar gene expression responses. The use of the mutant opt3-2, which accumulates high levels of iron, helps identify gene clusters that are repressed in the wild type but induced by cadmium. The data suggest that hydrogen peroxide may regulate iron deficiency responses by preventing the induction of specific genes.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Environmental Sciences
Xiaorong Yang, Jingping Hu, Longsheng Wu, Huijie Hou, Sha Liang, Jiakuan Yang
Summary: Inspired by the role of heme, iron porphyrin was used as a novel homogeneous catalyst to overcome the limitations of Fenton systems. Multiple active species were identified during the activation of H2O2, which allowed the degradation of pollutants over a wide pH range through their cooperative behavior. This study provides a new approach to wastewater treatment and sheds light on the interaction between metalloporphyrin and peroxide in an aqueous solution.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Hamed Vafaei Molamahmood, Wei Geng, Yan Wei, Jie Miao, Shiqin Yu, Ali Shahi, Chao Chen, Mingce Long
Summary: This study investigates the decomposition of H2O2 over six different iron minerals and finds hematite and goethite to be the most promising minerals for environmental cleanup due to their high ROS production. Magnetite and maghemite are highly active for both H2O2 decomposition and O-2 production at neutral and basic pHs. Ferrihydrite and feroxyhyte, on the other hand, are problematic minerals for CHP as they have high O-2 production and negligible ROS generation at all pHs.
Article
Engineering, Environmental
Xiaoshan Zheng, Binbin Wu, Chong Zhou, Tian Liu, Yanling Wang, Guoqiang Zhao, Baoliang Chen, Chiheng Chu
Summary: This study found that three naturally abundant iron minerals can generate photochemical reactive oxygen species (ROS) under sunlight irradiation, with hydroxyl radicals and hydrogen peroxide as major ROS species. Compared with organic photosensitizers, iron minerals exhibit higher wavelength dependence, higher selectivity, lower efficiency, and long-term stability in photochemical ROS production. This study highlights the natural inorganic iron mineral photochemistry as a ubiquitous yet previously overlooked source of ROS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomonori Hayashi, Kyoji Furukawa, Yukari Morishita, Ikue Hayashi, Naohiro Kato, Kengo Yoshida, Yoichiro Kusunoki, Seishi Kyoizumi, Waka Ohishi
Summary: This study showed that high levels of specific ROS within blood cells can be linked to enhanced inflammatory status and aging, especially after high-dose radiation exposure.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Environmental
Guoqiang Zhao, Mengxi Tan, Binbin Wu, Xiaoshan Zheng, Ruoxuan Xiong, Baoliang Chen, Andreas Kappler, Chiheng Chu
Summary: Tidal-induced redox oscillations can activate thermodynamically stable iron minerals into a metastable phase for enhanced ROS production.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yaru Zhang, Zhaocong Zheng, Zhankun Chen, Xiaozhao Wang, Wei Chen, Zhimin Gao, Jiamin Luo, Chen Lin, Wenyu Xie, Yuchi Wan, Meiling Tan, Donglian Liu, Zhiyao Hou
Summary: Researchers have successfully achieved reactive oxygen species (ROS) augmentation in mild photothermal therapy (mPTT) by fabricating Au@Pd bimetallic nanozyme. This nanozyme exhibits multienzymatic activities for photothermal conversion and induces ROS generation, which helps to suppress the heat-defense response of tumor cells and improves therapeutic efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)