Article
Chemistry, Applied
Ramya Prabaharan, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam, Jan Grzegorz Malecki
Summary: The study synthesized six new arene ruthenium (II) complexes and evaluated their anticancer activity through MTT assay and staining techniques, demonstrating good cytotoxicity against cancer cell lines, particularly with complex 6 showing potential anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Dalila Iacopini, Jan Vanco, Sebastiano Di Pietro, Vittorio Bordoni, Stefano Zacchini, Fabio Marchetti, Zdenek Dvorak, Tomas Malina, Lorenzo Biancalana, Zdenek Travnicek, Valeria Di Bussolo
Summary: Glycoconjugation is a powerful strategy to enhance the anticancer activity of metal complexes. In this study, glycoconjugated ruthenium(II) p-cymene complexes were synthesized by modifying commercial arylphosphanes with carbohydrate-derived fragments. These complexes exhibited significant cytotoxicity against various cancer cell lines and showed potential as novel anticancer agents.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Franco Bisceglie, Giorgio Pelosi, Nicolo Orsoni, Marianna Pioli, Mauro Carcelli, Paolo Pelagatti, Silvana Pinelli, Peter J. Sadler
Summary: We synthesized and characterized three half-sandwich Ru(II) arene complexes with different ligands, where one of the complexes exhibited good phototoxicity towards lung cancer cells upon blue light irradiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Alba Hernandez-Garcia, Lenka Markova, Maria Dolores Santana, Jitka Pracharova, Delia Bautista, Hana Kostrhunova, Vojtech Novohradsky, Viktor Brabec, Jose Ruiz, Jana Kasparkova
Summary: This study presents the synthesis and characterization of six new heteroleptic osmium(II) complexes with varying substituents in the R3 position of the phenyl ring of the cyclometalating C^N ligand. These complexes are highly kinetically inert and absorb a full-wavelength range of visible light. The antiproliferative activity of these complexes has been investigated using human cancer and noncancerous cell cultures, showing that they are more potent than conventional cisplatin. The mechanism of action involves the activation of the endoplasmic reticulum stress pathway and disruption of calcium homeostasis.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Urszula K. Komarnicka, Sandra Koziel, Agnieszka Skorska-Stania, Agnieszka Kyziol, Francesco Tisato
Summary: In this study, new complexes based on ruthenium(II) and iridium(III) with phosphine ligands and phenyl rings with/without methoxy motifs were synthesized and characterized. The complexes showed high catalytic efficiency in the oxidation of NADH to NAD(+) and exhibited potential applications in biological and medical fields. Furthermore, they demonstrated redox activity and significant cytotoxicity against various cancer cell lines.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Isabelle Holzer, Oksana Desiatkina, Nicoleta Anghel, Serena K. K. Johns, Ghalia Boubaker, Andrew Hemphill, Julien Furrer, Emilia Paunescu
Summary: Eight novel carbohydrate-tethered trithiolato dinuclear ruthenium(II)-arene complexes were synthesized and evaluated for their activity against transgenic T. gondii tachyzoites. Seven conjugates strongly inhibited parasite proliferation while maintaining HFF viability. Two galactose-based conjugates (23 and 26) exhibited low IC50 values and reduced toxicity compared to the non-modified complexes.
Article
Chemistry, Multidisciplinary
Qi-Yuan Yang, Rui Ma, Yun-Qiong Gu, Xiao-Fang Xu, Zhen-Feng Chen, Hong Liang
Summary: Targeting metabolic reprogramming to treat cancer, by using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming, could increase overall survival and reduce side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Yuliang Yang, Xiaofeng Zou, Yanyan Sun, Feihong Chen, Jian Zhao, Shaohua Gou
Summary: This article presents a rational design of half-sandwich Ru(II) complexes for mitochondria-targeted anticancer and antimetastatic agents by introducing the NDI unit into the N,N-chelating ligand of these complexes, which exhibit excellent emission performance. These complexes have potential applications in the design of multifunctional theranostic agents and fluorescent biomarkers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Ilona Gurgul, Olga Mazuryk, Kamila Stachyra, Rafal Olszanecki, Malgorzata Lekka, Michal Lomzik, Franck Suzenet, Philippe C. Gros, Malgorzata Brindell
Summary: Polypyridyl Ru complexes can alter cell adhesion properties and inhibit endothelial cell migration and pseudovessel formation, thereby inhibiting angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Oksana Desiatkina, Martin Moesching, Nicoleta Anghel, Ghalia Boubaker, Yosra Amdouni, Andrew Hemphill, Julien Furrer, Emilia Paunescu
Summary: A library of nucleobase-tethered trithiolato-bridged dinuclear ruthenium(II)-arene conjugates was synthesized and evaluated for their anti-Toxoplasma activity. Two promising compounds were identified, which exhibited low toxicity against host cells and have potential as treatment options.
Article
Chemistry, Multidisciplinary
Jonathan Long, Divyaratan Kumar, Claire Deo, Pascal Retailleau, Galina V. Dubacheva, Guy Royal, Juan Xie, Nicolas Bogliotti
Summary: Novel arene Ru-II complexes containing 2,2'-azobispyridine ligands were synthesized and characterized, showing unprecedented seven-membered chelate rings and irreversible isomerization to corresponding five-membered chelate complexes under light or electrochemical stimulus.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Tamara Petrovic, Nevenka Gligorijevic, Ferdinand Belaj, Sandra Arandelovic, Ljiljana E. Mihajlovic-Lalic, Sanja Grguric-Sipka, Jelena Poljarevic
Summary: In this study, three Re(V) complexes were synthesized and characterized, and their cytotoxicity against breast adenocarcinoma and pancreatic adenocarcinoma cells was investigated. One of the complexes, C1, showed dose-dependent cytotoxic potential and enhanced antiproliferative action in combination with an inhibitor of efflux transporter P-glycoprotein. Depletion of glutathione further increased the activity of C1.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Margetic, Stefan Nikolic, Sanja Grguric-Sipka, Miroslava T. Vujcic
Summary: This article investigates the interaction of four arene ruthenium complexes with DNA, revealing their DNA-binding activity, quenching properties, and antimicrobial activity against bacteria.
Article
Chemistry, Inorganic & Nuclear
Ljiljana E. Mihajlovic-Lalic, Dalibor Stankovic, Irena Novakovic, Sanja Grguric-Sipka
Summary: Three ruthenium-bipyridine complexes carrying acetylpyridine ligand unit were synthesized and characterized in this study. Their electrochemical activity, DNA-binding activity, antimicrobial activity, in vitro toxicity, and radical scavenging capacity were evaluated. The compounds showed moderate antimicrobial activity, no toxicity, and no antioxidant activity.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Irina Kuznetcova, Marija Ostojic, Nevenka Gligorijevic, Sandra Arandelovic, Vladimir B. Arion
Summary: A newly synthesized ring system compound, 5,6,7,9-tetrahydro-8H-indolo[3,2-e]benzazocin-8-one, along with its ligands and metal complexes, exhibits significant anticancer activity, surpassing cisplatin.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Boris M. Popovic, Nevenka Gligorijevic, Sandra Arandelovic, Ana Catarina Macedo, Tatjana Juric, Denis Uka, Karolina Mocko-Blazek, Ana Teresa Serra
Summary: This study investigated the cytotoxic profile of twelve choline chloride-based deep eutectic solvents (NADES) on HT-29, Caco-2, MCF-7, and MRC-5 cell lines. The cytotoxic effect was found to depend on the structure of the hydrogen bond donor (HBD). Acidic systems with organic acids as HBDs showed the highest cytotoxic effects, especially on the HT-29 cell line. The cytotoxicity was influenced by the concentration of the NADES system in the cell medium and the chemical constitution of the systems.
Review
Biochemistry & Molecular Biology
Tomislav Pejcic, Milica Zekovic, Uros Bumbasirevic, Milica Kalaba, Irena Vovk, Maja Bensa, Lazar Popovic, Zivoslav Tesic
Summary: This narrative review provides an overview of the epidemiological studies on breast cancer and prostate cancer, with a focus on the global incidence distribution and diet-related factors. It discusses the potential role of isoflavones in preventing these cancers by examining their biological properties, mechanisms of action, and available data. The review also summarizes studies on the effects of isoflavones in breast and prostate tissue, including their impact on cellular molecular signaling pathways and oxidative stress, as well as the levels of isoflavones in tissues and secretions.
Article
Chemistry, Inorganic & Nuclear
Christopher Wittmann, Tim Gruene, Alexander Prado-Roller, Sandra Arandelovic, Johannes Reynisson, Vladimir B. B. Arion
Summary: A series of latonduine derivatives were synthesized and characterized using spectroscopic and mass spectrometry techniques. The molecular structures of some compounds were confirmed by X-ray diffraction or electron diffraction. The antiproliferative activity of these compounds in different cancer cells and normal cells was evaluated by MTT assays.
Article
Chemistry, Inorganic & Nuclear
Marija V. Dimitrijevic, Ljiljana E. Mihajlovic-Lalic, Sanja Grguric-Sipka, Tatjana M. Mihajlov-Krstev, Dragoljub L. Miladinovic, Jelena M. Poljarevic
Summary: Eleven new and three reported half-sandwich Ru(II) arene complexes were synthesized and evaluated for their in vitro antibacterial and antifungal activity. The structures and purity of the compounds were confirmed using various spectroscopic and analytical techniques. The ligands exhibited better inhibitory effect against Gram-positive bacteria compared to the metal complexes, while all synthesized complexes showed similar activity against Candida albicans.
JOURNAL OF COORDINATION CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tanja V. Soldatovic, Biljana Smit, Emina M. Mrkalic, Sanja Lj. Matic, Ratomir M. Jelic, Marina Cendic Serafinovic, Nevenka Gligorijevic, Milena Cavic, Sandra Arandelovic, Sanja Grguric-Sipka
Summary: Novel Pt-Zn complexes were synthesized and characterized. The complexes showed strong binding to DNA through groove binding, hydrogen bonds, and hydrophobic or electrostatic interaction. Among them, C2 exhibited highly selective cytotoxicity and induced cell cycle arrest and expression of apoptotic related genes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Horticulture
Milica Fotiric Aksic, Zivoslav Tesic, Milica Kalaba, Ivanka Ciric, Lato Pezo, Biljana Loncar, Uros Gasic, Biljana Dojcinovic, Tomislav Tosti, Mekjell Meland
Summary: The aim of this study was to identify the chemical parameters for distinguishing plum cultivars grown in different regions of Norway. Chemical analysis of 68 plum cultivars revealed variations in the contents of elements, sugars, organic acids, phenolic compounds, and antioxidant activity. These differences have implications for human health and future breeding efforts.
Article
Biochemistry & Molecular Biology
Aleksandar Mijatovic, Nevenka Gligorijevic, Dusan Cocic, Snezana Spasic, Aleksandar Lolic, Sandra Arandelovic, Milan Nikolic, Rada Baosic
Summary: The biological activity of six structurally similar tetradentate Schiff base copper(II) complexes was investigated. One of the complexes, CuAA, showed superior antioxidant activity than Trolox, as well as antimicrobial, antifungal, and antiproliferative properties. The complexes also interacted with human serum albumin and DNA fragments.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Marijana Pavlovic, Emira Kahrovic, Sandra Arandelovic, Sinisa Radulovic, Predrag-Peter Ilich, Sanja Grguric-Sipka, Nevzeta Ljubijankic, Dijana Zilic, Jurica Jurec
Summary: Novel ruthenium(III) complexes were synthesized and characterized. These complexes showed potential cytoselective activity and exhibited high cytotoxicity against breast cancer cells.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Adrian Douglas Bugeja, Milica Nesovic, Branko Sikoparija, Predrag Radisic, Tomislav Tosti, Jelena Trifkovic, Luigi Russi, Everaldo Attard, Zivoslav Tesic, Uros Gasic
Summary: This study analyzed honey from Malta collected during different seasons, providing data on its chemical composition and characteristics. The research found that honey from different seasons had distinct chemical profiles and specific compounds.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)