期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 105, 期 11, 页码 1457-1463出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2011.08.006
关键词
Aluminum; Macrophagic myofasciitis; Vaccine; Mild cognitive impairment; Alzheimer
资金
- Association Francaise contre les Myopathies (AFM)
- Entraide aux Malades de la Myofasciite a Macrophages (E3M)
Macrophagic myofasciitis (MMF) is characterized by specific muscle lesions assessing long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients are middle-aged adults, mainly presenting with diffuse arthromyalgias, chronic fatigue, and cognitive dysfunction. Representative features of MMF-associated cognitive dysfunction (MACD) include (i) dysexecutive syndrome; (i) visual memory; (iii) left ear extinction at dichotic listening test In present study we retrospectively evaluated the progression of MACD in 30 MMF patients. Most patients fulfilled criteria for non-amnestic/dysexecutive mild cognitive impairment, even if some cognitive deficits seemed unusually severe. MACD remained stable over time, although dysexecutive syndrome tended to worsen. Long-term follow-up of a subset of patients with 3 or 4 consecutive neuropsychological evaluations confirmed the stability of MACD with time, despite marked fluctuations. (C) 2011 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据