期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 105, 期 11, 页码 1513-1517出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2011.07.001
关键词
Al toxicity; Astrocytes; Fat factories; Globular; ATP; L-carnitine
资金
- Laurentian University and Industry Canada
- NSERC
Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders. (C) 2011 Elsevier Inc. All rights reserved.
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