Article
Chemistry, Inorganic & Nuclear
Rafaella Rebecchi Rios, Phamilla Gracielli Sousa Rodrigues, Juliana C. Biazzotto, Sergio Emanuel Galembeck, Roberto Santana da Silva
Summary: Nitrogen oxide derivative ruthenium compounds can release nitric oxide through chemical, electrochemical, or photochemical processes. Among them, nitrosyl ruthenium complexes have been extensively studied and the properties of ligands greatly affect the structure and NO delivery mode.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Spectroscopy
Artem A. Mikhailov, Theo Woike, Axel Gansmuller, Dominik Schaniel, Gennadiy A. Kostin
Summary: Photoinduced NO-linkage isomers in a labelled trans-[Ru((NO)-N-14/15)(py(4))F](ClO4)(2) complex were investigated in the solid state using IR-spectroscopy and DFT calculations. The experimental data and calculations allowed for a complete assignment of vibrational bands and provided insights into the structural changes leading to the downshift of certain bands. Long-time irradiation may induce irreversible reactions, such as the release of NO or nitrous oxide N2O.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Inorganic & Nuclear
Andrew C. Benniston, Lingli Zeng
Summary: This perspective article provides an overview of recent studies on metal-based complexes with ligands that are expelled under light activation, focusing primarily on ligands with potential biological activity and therapeutic applications.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Arij Farhat, Marine Tasse, Mathilde Boce, Dominique de Caro, Isabelle Malfant, Patricia Vicendo, Anne-Francoise Mingotaud
Summary: We have successfully synthesized photoactivable ruthenium nitrosyl complex nanoparticles, and characterized their sizes using atomic force microscopy and nanoparticle tracking analysis. The nanoparticles released nitric oxide (NO) upon irradiation at 365 nm, with a quantum yield of about 0.04. Electron paramagnetic resonance and NO sensor measurements confirmed the NO release. These nanoparticles offer spatiotemporal control of NO release and hold great potential as NO nanoplatforms for biological applications.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Chemistry, Physical
Elena D. Stolyarova, Artem A. Mikhailov, Anton A. Ulantikov, Julia A. Eremina, Lyubov S. Klyushova, Natalia Kuratieva, Vladimir A. Nadolinny, Gennadiy A. Kostin
Summary: Two nitrosyl complexes were synthesized and characterized, showing light-induced NO release and cytotoxicity against breast adenocarcinoma cells. Photolysis and electrochemical techniques were used to investigate the activation of NO, and DFT calculations revealed possible charge transfers responsible for the activation. The study opens up possibilities for designing and synthesizing new compounds with photo-sensitive and cytotoxic properties.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hai -Lin Zhang, Yi Wang, Qi Tang, Bing Ren, Shi-Ping Yang, Jin -Gang Liu
Summary: A hollow mesoporous manganese dioxide-based multifunctional nanoplatform was developed for synergistic cancer treatment, which loaded a histone deacetylase inhibitor AFIPB in its hollow cavity and covalently decorated a ruthenium nitrosyl donor and a folic acid targeting group on its covered polydopamine layer. The nanoplatform exhibited tumor microenvironment-responsive properties and could deplete glutathione to disrupt the antioxidant defense system and deliver drugs on demand. Furthermore, it could generate highly toxic hydroxyl radicals through the catalysis of released Mn2+ and produce controlled nitric oxide delivery and significant photothermal effect under 808 nm light irradiation, resulting in high mortality of cancer cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Andre Ferrarini, Rafael Natan Soek, Rafaella Rebecchi Rios, Francielli Sousa Santana, Renan Borsoi Campos, Roberto Santana da Silva, Fabio Souza Nunes
Summary: Two novel ruthenium-nitrosyl complexes were synthesized and characterized. RuLANO can release chloride ions and dissociate NO upon irradiation, while Ru3LBNO is photo-inactive in a specific wavelength range. These results are consistent with calculations and electrochemical responses.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Youngsuk Kim, Arun Sridharan, Daniel L. M. Suess
Summary: This study reports the synthesis of a three-member series of isostructural mononitrosylated [Fe4S4] clusters and reveals the significance of mononitrosylated intermediates in NO sensing/signaling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Nancy Sharma, Porkizhi Arjunan, Srujan Marepally, Nimisha Jain, Abbas Raja Naziruddin, Amrita Ghosh, C. R. Mariappan, D. Amilan Jose
Summary: A new nano-scale vesicle-based platform for light-controlled release of nitric oxide (NO) has been reported. The platform is water-soluble, biocompatible, and allows for easy modulation of NO release by changing the concentration. This method shows potential for therapeutic applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
A. A. Mikhailov, E. D. Stolyarova, G. A. Kostin
Summary: The review focuses on photochemical transformations of ruthenium nitrosyl complexes in various media and their potential applications, including reversible photoisomerization reactions in solids and photolysis reactions in solutions.
JOURNAL OF STRUCTURAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Yael Juarez-Martinez, Pablo Labra-Vazquez, Pascal G. Lacroix, Marine Tasse, Mathilde Boce, Sonia Mallet-Ladeira, Isabelle Malfant
Summary: Four crystal structures containing bis-fluorene fragment with alkyl chains (methyl and hexyl) are presented. The possibility of obtaining both cisoid and transoid conformations in the bis-fluorene units is discussed. Computational investigation shows a tendency for the gradual stabilization of the cisoid form as the length of the chains increases. The effect of conformation on the charge transfer electronic properties of bis-fluorene based materials is found to be modest.
Article
Biochemistry & Molecular Biology
Hadeer A. Shereef, Yasmine S. Moemen, Fawzia I. Elshami, Ahmed M. El-Nahas, Shaban Y. Shaban, Rudi van Eldik
Summary: This study aimed to evaluate the in vitro DNA binding mechanism of [RuNOTSP](+) and TSPH2, correlate the findings with cleavage activity and determine the impact of the metal center. Theoretical studies and biophysical techniques were used to examine the binding of [RuNOTSP](+) and TSPH2 to ctDNA. The results showed that both compounds effectively bind to ctDNA via intercalative/electrostatic interactions and that [RuNOTSP](+) has a greater DNA binding propensity than TSPH2. The study also revealed that cationic [RuNOTSP](+) is more effective at cleaving DNA compared to TSPH2.
Article
Chemistry, Inorganic & Nuclear
Olesya Pokidova, Alexandra Yu Kormukhina, Alexander Kotelnikov, Tatyana N. Rudneva, Konstantin A. Lyssenko, Natalia A. Sanina
Summary: The study revealed that two cationic dinitrosyl iron complexes interact with proteins, leading to their stabilization, especially in the absence of oxygen. The different coordination modes and stabilities of the complexes with proteins were indicated by the interactions observed.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
N. A. Sanina, I. V. Sulimenkov, N. S. Emel'yanova, A. S. Konyukhova, T. S. Stupina, A. A. Balakina, A. A. Terent'ev, S. M. Aldoshin
Summary: The cytotoxic activity of dinitrosyl iron complexes (DNICs) with thioureas against cells has been studied, and the results show that the cytotoxicity depends on the complex structure and cell line. The release of NO during the decomposition of DNICs does not correlate with their cytotoxic effects, suggesting that the formation of long-lived nitrosyl iron-sulfur intermediates is responsible for the cytotoxic activity. The structures of the decomposition products have been analyzed, and stable high-molecular cluster ions containing NO groups have been detected.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Maria Oszajca, Angelika Jodlowska, Dorota Rutkowska-Zbik, Konrad Kieca, Grazyna Stoche
Summary: Conversion of NO to stable S-nitrosothiols is a significant biological strategy of NO storage and signal transduction, and metal ions and metalloproteins can promote the formation of S-nitrosothiols from NO. This study investigates the incorporation of NO to biologically relevant thiols using a model protein heme center. The formation of S-nitrosothiols is confirmed under anaerobic conditions, and the molecular mechanism involving N-coordinated S-nitrosothiols is elucidated. This work highlights the importance of reversible NO binding as a biological strategy for NO storage.
INORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Paula Priscila Correia Costa, Stefanie Bressan Waller, Gilvan Ribeiro dos Santos, Fladimir de Lima Gondim, Daniel Silveira Serra, Francisco Sales Avila Cavalcante, Florencio Sousa Gouveia Junior, Valdir Ferreira de Paula Junior, Eduardo Henrique Silva Sousa, Luiz Gonzaga de Franca Lopes, Wesley Lyeverton Correia Ribeiro, Helena Serra Azul Monteiro
Summary: The nitrosyl-ruthenium compound FOR811A showed anti-asthmatic effects by improving lung function, relaxing bronchial smooth muscles, and interacting strongly with a specific protein at the molecular level.
Article
Chemistry, Medicinal
Tercio de Freitas Paulo, Carine Duhayon, Luiz Gonzaga de Franca Lopes, Eduardo Henrique Silva Sousa, Remi Chauvin, Vania Bernardes-Genisson
Summary: A chemical activation study was conducted on thiocarbonyl-type antitubercular prodrugs, revealing the preferential formation of stable S-oxide compounds in solution and their reactivity with amines. The unstable intermediates and multiple metabolites generated during oxidation could potentially contribute to the toxicity of these prodrugs.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Review
Chemistry, Inorganic & Nuclear
Luiz Gonzaga de Franca Lopes, Florencio S. Gouveia Junior, Alda Karine Medeiros Holanda, Idalina Maria Moreira de Carvalho, Elisane Longhinotti, Tercio F. Paulo, Dieric S. Abreu, Paul Bernhardt, Marie-Alda Gilles-Gonzalez, Izaura Cirino Nogueira Diogenes, Eduardo Henrique Silva Sousa
Summary: This article discusses the roles of diatomic molecules O-2, NO, and CO in biology, as well as the sensing proteins developed by nature to perceive and respond to changes in their levels. It focuses on heme-based proteins and their advanced structural and electronic adjustments for sensing, along with their possible role in redox sensing. Finally, the potential therapeutic interventions on these gas sensors and the design of small diatomic molecules for medical treatments are highlighted.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Pedro Martins da Silva Filho, Alexandre Lopes Andrade, Jessica Barros Arrais Cruz Lopes, Aryane de Azevedo Pinheiro, Mayron Alves de Vasconcelos, Said Goncalves da Cruz Fonseca, Luiz Gonzaga de Franca Lopes, Eduardo Henrique Silva Sousa, Edson Holanda Teixeira, Elisane Longhinotti
Summary: The study found that silica nanoparticles containing nitroprusside could serve as a nitric oxide donor agent with significant antibacterial effects against resistant Staphylococcus strains, especially when used in combination with antibiotics like ampicillin. While showing moderate activity in blocking biofilm production, the nanomaterial demonstrated a remarkable decrease in the number of viable bacterial cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Fatima Virginia Gama Justi, Gabriella Araujo Matos, Juan de Sa Roriz Caminha, Cassia Rodrigues Roque, Edinilton Muniz Carvalho, Marcio Wilker Soares Campelo, Ludmila Belayev, Luiz Gonzaga de Franca Lopes, Reinaldo Barreto Oria
Summary: Ruthenium compounds have emerged as a promising therapeutic alternative in anticancer chemotherapy and neuroprotective agents. This minireview summarizes their roles in cancer, neuroinflammation, neurovascular, and neurodegenerative diseases, highlighting their potential in gliomas and brain cancers, cerebral ischemia-reperfusion, nociceptive and inflammatory events, and early Alzheimer's disease. Further research is needed to investigate the biological effects and therapeutic mechanisms of ruthenium.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Juliana S. do Nascimento, Aurideia P. de Sousa, Ana C. S. Gondim, Eduardo H. S. Sousa, Edson H. Teixeira, Luiz Gonzaga do Nascimento Neto, Beatriz Pinheiro Bezerra, Alejandro Pedro Ayala, Alzir A. Batista, Igor F. Vasconcelos, Francisco G. S. Oliveira, Alda K. M. Holanda
Summary: A new binuclear metal complex has been synthesized and shown to exhibit DNA cleavage activity in vitro. This study further demonstrates the essential role of metal binding to an anthracycline-like moiety in the generation of reactive oxygen species (ROS).
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Biology
Gabriela Maria da Silva, Mirelly Cunha da Silva, Deborah Victoria Gomes Nascimento, Ellen Mayara Lima Silva, Fabiola Furtado Fialho Gouvea, Luiz Gonzaga de Franca Lopes, Alice Valenca Araujo, Kelli Nogueira Ferraz Pereira, Thyago Moreira de Queiroz
Summary: Nitric oxide plays crucial physiological roles in the cardiovascular system, and its deficiency can lead to cardiovascular diseases such as hypertension. Nitric oxide donors are clinically beneficial in treating cardiovascular disorders by modulating oxidative stress and inflammation, particularly in conditions like hypertension. Novel NO donors, especially those containing metal ions, show promising potential in improving vascular function and treating hypertension.
Article
Pharmacology & Pharmacy
Isadora Oliveira Carvalho, Cleo Vanessa Gomes Queiroz, Gabriela Fernandes Oliveira Marques, Raquel Magalhaes Castelo Branco Craveiro, Francisco Antonio Felix Xavier Junior, Florencio Sousa Gouveia Junior, Luiz Gonzaga de Franca Lopes, Edna Maria Camelo Chaves, Helena Serra Azul Monteiro, Ana Maria Sampaio Assreuy, Janaina Serra Azul Monteiro Evangelista
Summary: The metal coordination complex FOR811A exhibits anti-inflammatory and antioxidant effects in mouse models of inflammation, achieved through the nitric oxide pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joselito de Oliveira Neto, Marcia Machado Marinho, Joao Alison de Moraes Silveira, Danilo Galvao Rocha, Natalia Cavalcante Barbosa Lima, Florencio Sousa Gouveia Junior, Luiz Gonzaga de Franca Lopes, Eduardo Henrique Silva de Sousa, Alice Maria Costa Martins, Aline Diogo Marinho, Roberta Jeane Bezerra Jorge, Helena Serra Azul Monteiro
Summary: This study investigated the synthesis and potential vasodilator effect of a novel ruthenium complex containing an imidazole derivative. Computational simulations predicted the pharmacokinetic properties of the complex, while in vitro experiments demonstrated its non-irritant nature and confirmed its vasodilator effect. These findings suggest the potential therapeutic application of the complex as a vasodilator.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Patricia H. R. Martins, Adolfo I. B. Romo, Francisco O. N. da Silva, Otaciro R. Nascimento, Joaquin Rodriguez-Lopez, Izaura C. N. Diogenes, Luiz G. F. Lopes, Eduardo H. S. Sousa
Summary: The role and reactivity of metal complexes in interacting with DNA, especially metallonitrosyl compounds, have been poorly investigated. A nitrosyl compound cis-[Ru(bpy)(2)(SO3)(NO)](PF6)(A) exhibited promising biological activities, while a final product cis-[Ru(bpy)(2)(SO3)(H2O](B) showed important reactivity with H2O2 causing DNA degradation. The aqua product of the nitrosyl ruthenium complex should be further studied for its potential genotoxicity to DNA.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Pedro Martins da Silva, Iury Araujo Paz, Nilberto Robson Falcao do Nascimento, Dieric S. Abreu, Luiz Gonzaga de Franca Lopes, Eduardo Henrique Silva Sousa, Elisane Longhinotti
Summary: Sodium nitroprusside (SNP), a drug used to treat severe hypertension in hospital emergency settings, has emerged with new clinical uses in recent years. This drug functions by releasing nitric oxide (NO), but due to its short lifetime, NO donor molecules are used for administration. Currently, there are various drug delivery strategies that can overcome the limitations of SNP, providing new opportunities for its use. This Perspective highlights the properties of SNP and emphasizes the potential therapeutic uses arising from the use of drug delivery systems such as silica-based nanoparticles.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Florencio Sousa Gouveia Junior, Joao Alison de Moraes Silveira, Thais Muratori Holanda, Aline Diogo Marinho, Lisa A. Ridnour, David A. Wink, Rodrigo Jose Bezerra de Siqueira, Helena Serra Azul Monteiro, Eduardo Henrique Silva de Sousa, Luiz Gonzaga de Franca Lopes
Summary: In this study, two new nitrosyl ruthenium complexes were developed and characterized. These complexes showed potential for releasing nitric oxide and nitroxyl, which can be beneficial for cardiovascular diseases. They also demonstrated antioxidant and vasodilating properties.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
