期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 105, 期 3, 页码 400-409出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2010.12.002
关键词
Pt(II) derivatives; X-ray diffraction; Cytotoxicity; Lipophilicity; Molecular interaction fields
资金
- Regione Piemonte [A 370]
- ATF Association (Alessandria, Italy)
The syntheses, structures and biological evaluation of a series of cisplatin-like complexes containing bis (imidazole) derivatives - the so-called Joseph ligands - are described. Their cytotoxicity is discussed in terms of their polar surface area, rate of aquation, and lipophilicity. The X-ray crystal structure of the platinum diiodido derivative of dimethyl 2-(di(1H-imidazol-2-yl)methyl)malonate) is reported and compared to those of related systems. Molecular modeling studies are focused on the hydrogen bonding properties of such systems, and their relevance to antitumor activity. (C) 2010 Elsevier Inc. All rights reserved.
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