☆ 4.6 Article

Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates

JOURNAL OF INORGANIC BIOCHEMISTRY (2011)

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JOURNAL OF INORGANIC BIOCHEMISTRY
卷 105, 期 3, 页码 462-466

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2010.08.010

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Pt complexes; Cytotoxicity; cis geometry; X-ray structure; Thiocarbamate ligands

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Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear

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  1. Fonds der Chemischen Industrie
  2. DFG

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The thiocarbamates 4-RC6H4NHC(S)NR2' (R = H, Cl; R' = Me, Et), 4-ClC6H4NHC(S)NR (NR = 2-pyridylpiperazine) react with cis-[PtCl2(PTA)(2)] (PTA = 1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the monocationic platinum(II) complexes cis-[Pt(SC(NR2')= NC6H4R)(PTA)(2)](+) (R = H, Cl; R' = Me, Et), cis-[Pt{SC (NR) = NC6H4Cl}(PTA)(2)](+) (NR = 2-pyridylpiperazine), which were isolated as their PF6 salts in high yields. The complexes were fully characterised spectroscopically and also by X-ray crystallography. Cytotoxicity of these complexes was studied in vitro in three human cancer cell lines (CH1, A549 and SW480) using the MTT assay. (C) 2010 Elsevier Inc. All rights reserved.

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