Review
Chemistry, Organic
Harshita Shet, Udaysinh Parmar, Shatrughn Bhilare, Anant R. Kapdi
Summary: Phosphines have been crucial in the development of transition metal-catalysed processes, overcoming synthesis challenges through fine-tuning electronic and steric properties. Caged phosphines, with excellent control over steric and electronic properties, are widely used as ligands in catalytic reactions.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Neurosciences
Melissa A. Tapia, Xiao-Tao Jin, Brenton R. Tucker, Leanne N. Thomas, Noah B. Walker, Veronica J. Kim, Steven E. Albertson, Naresh Damuka, Ivan Krizan, Seby Edassery, Jeffrey N. Savas, Kiran Kumar Solingapuram Sai, Sara R. Jones, Ryan M. Drenan
Summary: This study investigated the behavior and neurobiological effects of intermittent nicotine intake in rats. The results suggest that intermittent nicotine intake may lead to increased craving and enhanced response to nicotine-associated cues. Additionally, intermittent nicotine intake also caused increased nicotine binding in the brain and specific changes in the proteome of certain neural structures.
Article
Dentistry, Oral Surgery & Medicine
Yang Du, Kuan Yang, Zhifei Zhou, Lizheng Wu, Lulu Wang, Yujiang Chen, Xin Ge, Xiaojing Wang
Summary: Nicotine regulates autophagy of human periodontal ligament cells (hPDLCs) through alpha 7 nAChR, which further regulates the release of inflammatory factors IL-1 beta and IL-8 from hPDLCs.
Article
Chemistry, Physical
Qian-qian Tan, Yan Guo, David Lee Phillips, Tongyu Xu, Jiani Ma
Summary: Femtosecond transient absorption, nanosecond transient absorption, and nanosecond resonance Raman spectroscopy techniques combined with density functional theory calculations were used to investigate the photocyclization and photorelease mechanisms of a diarylethene compound. This study provides a deeper understanding of these reactions and can aid in the future design of functionalized diarylethene derivatives for specific applications.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Talulla B. Palumbo, Julie. M. Miwa
Summary: Despite solid data supporting the involvement of nicotinic receptors in neurological and neuropsychiatric diseases, their potential as a therapeutic target has not been fully realized due to complex factors such as the widespread action of the cholinergic system and the biophysical mechanism of nicotinic receptors. Conventional drug development strategies focus on receptor subtype-specific action, while exploring the broad agonist nicotine in the clinic. Prototoxins, a little-explored avenue, show promise as nicotinic receptor drugs and have potential advantages over targeting specific receptor subtypes. Their allosteric effects and binding specificity provide possibilities for more effective and nuanced therapeutic approaches.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Chunxiang Liu, Yunbo Jiang, Teng Wang, Qiaosheng Li, Yuzhou Liu
Summary: The durability of RuO2 as an acidic oxygen evolution reaction catalyst can be significantly improved by pretrapping RuCl3 precursors within a cage compound possessing 72 aromatic rings, leading to well carbon-coated RuOx particles (Si-RuOx@C) after calcination. The catalyst exhibits excellent catalytic activity and stability during OER, while RuOx prepared from similar non-tied compounds does not show such performance.
Article
Environmental Sciences
Hui-yi Yan, Xiao Wen, Lan-zhou Chen, Yi-ting Feng, Han-xiao Liu, Wen Qu, Wen-hao Zhao, Dong-qin Xu, Jie Ping
Summary: Our study revealed that nicotine suppressed the development pathway of CD4(+)SP cells by inducing autophagy, shedding light on the developmental origin mechanism of programmed immune diseases in PNE offspring.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
A. Alzu'bi, M. S. Al Zoubi, G. T. Abdelhady, B. Al-Trad, S. Omari, M. Abualarjah, W. El-Huneidi, D. R. Alzu'bi, J. M. Bani-Issa, G. J. Clowry
Summary: This study found that exposure to nicotine during pregnancy can lead to decreased fetal growth and weight, as well as reduced placental size. This is accompanied by increased apoptosis within the placenta, while the expression of angiogenic factors remains unchanged.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hironori Takahashi, Mako Kamiya, Minoru Kawatani, Keitaro Umezawa, Yoshiaki Ukita, Shinsuke Niwa, Toshiyuki Oda, Yasuteru Urano
Summary: By developing BODIPY-derived caged compounds that release bioactive phenol derivatives upon illumination in the yellow wavelength range, optical control of neural activity in Caenorhabditis elegans can be achieved without inducing a photophobic response or crosstalk between uncaging and simultaneous fluorescence monitoring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Romana Jarosova, Sam Kaplan, Thomas M. Field, Richard S. Givens, Sanjeewa N. Senadheera, Michael A. Johnson
Summary: The study developed an in situ electrochemical method to determine the release of caged compounds by using fast-scan cyclic voltammetry at carbon-fiber microelectrodes. A linear calibration curve for the released glutamate was established using a model system and high-performance liquid chromatography. This approach allowed for the correction of light artifacts and residual caged molecules in solution, demonstrating successful validation in intact zebrafish brain tissue.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Qiang Li, Jingtan Li, Jingting Wang, Jing Wang, Tong Lu, Yanfei Jia, Haiji Sun, Xiaoli Ma
Summary: Evidence has shown a strong relationship between smoking and epithelial mesenchymal transition (EMT) in lung adenocarcinoma (LUAD). This study identifies a novel pathway involving alpha 5-nicotinic acetylcholine receptor (alpha 5-nAChR), PLEK2, and CFL1 in nicotine-induced LUAD progression. The alpha 5-nAChR/PLEK2/CFL1 pathway contributes to cell migration, invasion, and stemness in LUAD.
MOLECULAR CARCINOGENESIS
(2023)
Article
Oncology
Yuzhi Wang, Tengfei Bian, Lina Song, Yunhan Jiang, Zhiguang Huo, Ramzi G. Salloum, Graham W. Warren, Frederic J. Kaye, Naomi Fujioka, Lingtao Jin, Chengguo Xing
Summary: Smoking is the dominant risk factor for small cell lung cancer (SCLC) and is associated with worse clinical outcomes and reduced efficacy of chemotherapy. Nicotine and its metabolite, cotinine, have been found to decrease the efficacy of platinum-based chemotherapies and accelerate chemoresistance in SCLC cells. These findings highlight the importance of tobacco cessation and control of nicotine replacement therapy in SCLC management.
Article
Biochemistry & Molecular Biology
Jessica IChi Lai, Alessandra Porcu, Benedetto Romoli, Maria Keisler, Fredric P. P. Manfredsson, Susan B. B. Powell, Davide Dulcis
Summary: This study investigated the mechanism of how nicotine-induced dopamine (DA) plasticity protects substantia nigra (SN) neurons against nigrostriatal damage in Parkinson's disease (PD). The results showed that chronic nicotine treatment led to upregulation of transcription factor Nurr1 and DA-synthesizing enzyme tyrosine hydroxylase (TH) in GABAergic neurons in the SN. Nicotine also reduced the number of alpha-synuclein-expressing neurons and rescued motor deficits in PD mice. Importantly, the activation of GABA neurons and Nurr1 overexpression were sufficient to mimic nicotine-mediated dopamine plasticity. This study provides insights into developing new strategies for neurotransmitter replacement in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Srijan Acharya, Dooti Kundu, Kyeong-Man Kim
Summary: The endocytosis of alpha 4 beta 2 nicotinic ACh receptors occurs through clathrin-mediated endocytosis in a dynamin-dependent manner. Src-mediated phosphorylation of the nAChR alpha 4 subunit at Y575 by 14-3-3 eta is required for endocytosis, with assistance from beta-arrestin1 and GRK2. Endocytosis leads to ubiquitination and down-regulation of alpha 4 beta 2 nAChRs.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Marcus Korb, Stephen A. Moggach, Paul J. Low
Summary: An unusual 1,2-ferrocenyl migration was observed after reactions of [Ru(dppe)Cp][BAr4F] with diferrocenylacetylene, expanding the scope of group rearrangments beyond methyl and phenyl entities. Bimetallic bis(vinylidene) complexes were formed from ferrocene-containing bis(alkynes) following two consecutive rearrangements.
CHEMICAL COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Jagoba Iturri, Luis Garcia-Fernandez, Ute Reuning, Andres J. Garcia, Aranzazu del Campo, Marcelo J. Salierno
SCIENTIFIC REPORTS
(2015)
Article
Engineering, Biomedical
Jonathan T. Pham, Longjian Xue, Aranzazu del Campo, Marcelo Salierno
ACTA BIOMATERIALIA
(2016)
Article
Chemistry, Multidisciplinary
Aleeza Farrukh, Julieta I. Paez, Marcelo Salierno, Aranzazu del Campo
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2016)
Article
Engineering, Biomedical
Marcelo J. Salierno, Luis Garcia-Fernandez, Noelia Carabelos, Karin Kiefer, Andres J. Garcia, Aranzazu del Campo
Article
Cell Biology
Alejandra V. Paez, Carla Pallavicini, Federico Schuster, Maria Pia Valacco, Jimena Giudice, Emiliano G. Ortiz, Nicolas Anselmino, Estefania Labanca, Maria Binaghi, Marcelo Salierno, Marcelo A. Marti, Javier H. Cotignola, Anna Woloszynska-Read, Luciana Bruno, Valeria Levi, Nora Navone, Elba S. Vazquez, Geraldine Gueron
CELL DEATH & DISEASE
(2016)
Article
Cell & Tissue Engineering
Aleeza Farrukh, Felipe Ortega, Wenqiang Fan, Nicolas Marichal, Julieta I. Paez, Benedikt Berninger, Aranzazu del Campo, Marcelo J. Salierno
Article
Engineering, Biomedical
Shifang Zhao, Wenqiang Fan, Xiang Guo, Longjian Xue, Benedikt Berninger, Marcelo J. Salierno, Aranzazu del Campo
Article
Biochemistry & Molecular Biology
Aleeza Farrukh, Wenqiang Fan, Shifang Zhao, Marcelo Salierno, Julieta I. Paez, Aranzazu del Campo
Article
Chemistry, Multidisciplinary
Marcelo J. Salierno, Andres J. Garcia, Aranzazu del Campo
ADVANCED FUNCTIONAL MATERIALS
(2013)
Article
Multidisciplinary Sciences
Ana Laura Ortalli, Luciano Fiore, Jennifer Di Napoli, Melina Rapacioli, Marcelo Salierno, Roberto Etchenique, Vladimir Flores, Viviana Sanchez, Nestor Gabriel Carri, Gabriel Scicolone
Article
Nanoscience & Nanotechnology
Aleeza Farrukh, Shifang Zhao, Julieta Paez, Atria Kavyanifar, Marcelo Salierno, Adolfo Cavalie, Aranzazu del Campo
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Plant Sciences
Nahuel Spinedi, Nadia Rojas, Romina Storb, Juan Cabrera, Elisabet Aranda, Marcelo Salierno, Maya Svriz, Jose Martin Scervino
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2019)
Meeting Abstract
Neurosciences
F. Ortega, A. Farrukh, W. Fan, N. Marichal, J. Paez, B. Berninger, A. Del Campo, M. Salierno
Article
Biochemistry & Molecular Biology
Aleeza Farrukh, Julieta I. Paez, Marcelo Salierno, Wenqiang Fan, Benedikt Beminger, Aranzazu del Campoti
Article
Rheumatology
L. Solfietti, G. B. Binello, S. Stella, M. Bazzan, M. Salierno, D. Roccatello
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
