☆ 4.6 Article

Hydrolytic cleavage of double-strand DNA by the water-soluble dicobalt(III) complexes of 1,4,7-Triazacyclononane-N-acetate

JOURNAL OF INORGANIC BIOCHEMISTRY (2010)

期刊

JOURNAL OF INORGANIC BIOCHEMISTRY

卷 104, 期 9, 页码 993-999

出版社

ELSEVIER SCIENCE INC

DOI: 10.1016/j.jinorgbio.2010.05.005

关键词

Cobalt(III) complexes; 1,4,7-triazacyclononane-N-acetate; mu-Hydroxo; Hydrolytic cleavage

类别

Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear

资金

National Natural Science Foundation of China [20771063]
PhD Science Foundation of Tianjin Normal University [52LX28]
Tianjin Educational Committee Foundation [20070606]

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Protocol

Reagent

摘要

Three water-soluble dicobalt(III) complexes, [Co2L2(mu-OH)(2)](ClO4)(2)center dot 5H(2)O (1), [Co2L2(mu-OH)(2)](ClO4)(2)center dot-CH3OH center dot H2O(2); [Co2L2(mu-OH)(2)](ClO4)(2)center dot 4H(2)O(3) (L = 1,4,7-triazacyclononane-N-acetate monoanion), were prepared to serve as nuclease mimics. The complexes were characterized by X-ray, IR and UV-vis spectroscopy as well as ESI-MS. Three complexes exhibit similar structures, just with different solvent molecules. The electrospray mass spectrum of 1 in solution indicates that dinuclear ion [Co2L2(mu-OH)(2)-H+](+) (4) is the active species. In the absence of any reducing agent, the complexes cleave plasmid pBR322 DNA was performed and its hydrolytic mechanism was demonstrated with radical scavengers, anaerobic reaction and T4 ligase. The kinetic aspects of DNA cleavage under pseudo- or true-Michaelis-Menten conditions are also detailed, kinetic parameters (k(cat), K-M) were calculated to be 3.57 h(-1), 6.92 x 10(-4) M; 0.28 h(-1), 1.9 x 10(-5) M for 4, respectively. (C) 2010 Elsevier Inc. All rights reserved.

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