Article
Chemistry, Inorganic & Nuclear
Jan Hormann, Olga Verbitsky, Xiaoyu Zhou, Beatrice Battistella, Margarete van der Meer, Biprajit Sarkar, Cunyuan Zhao, Nora Kulak
Summary: We synthesized and characterized Cu(ii) complexes CuL1-CuL6 with cyclen-based ligands. The ligands L-1-L-6 comprise different donor sets including S and O atoms. The substitution of N donor atoms with hard donor O atoms leads to efficient oxidative nucleases, but dissociation of the complex upon reduction. We are showing that the rational combination of O and S atoms next to two nitrogen donors within the macrocycle leads to the stabilization of both redox states, resulting in the highest oxidative DNA cleavage activity within this family of cyclen-based Cu(ii) complexes.
DALTON TRANSACTIONS
(2023)
Article
Polymer Science
M. Ali Aboudzadeh, Vanessa Rodriguez-Fanjul, Alessio Terenzi, Estibaliz Gonzalez de San Roman, Jose I. Miranda, Ana M. Pizarro, Luca Salassa, Fabienne Barroso-Bujans
Summary: We synthesized a macrocyclic poly(ethyleneoxide) (PEO) connected with a [Ru(bpy)(3)](2+) unit, which is a photoactive metal complex with potential biomedical applications. The PEO chain provides biocompatibility, water solubility, and topological play. The macrocycles were successfully synthesized by copper-free click cycloaddition and exhibited higher fluorescence lifetime compared to their linear analogues.
Review
Chemistry, Inorganic & Nuclear
Mateusz D. Tomczyk, Nikodem Kuznik, Krzysztof Walczak
Summary: The first part of the review summarizes more than three decades of research on cyclen complexes that exhibit hydrolytic or transesterification activity against phosphodiesters. The second part focuses on complexes that cleave phosphodiesters oxidatively. The review includes results for nearly 200 examples of metal complexes of cyclen and its derivatives, as well as metal-free catalysts based on the cyclen scaffold.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Francesco Bartoli, Luca Conti, Giammarco Maria Romano, Lara Massai, Paola Paoli, Patrizia Rossi, Giangaetano Pietraperzia, Cristina Gellini, Andrea Bencini
Summary: The synthesis of three new polyamine receptors based on a common cyclen platform with different appended fluorophores was reported. The study showed that the structural features of these receptors are controlled by a balance between hydrogen bonding and electrostatic repulsions in their protonated species, while their emission properties are tuned by photoinduced electron and/or proton transfer processes.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Danica Sabolova, Simona Sovova, Ladislav Janovec, Eva Timko, David Jager, Jana Tothova
Summary: Four novel 3,6-bis[(alkylamino)ureido]acridines were synthesized and characterized using NMR spectra. In vitro DNA binding studies showed that these compounds bind to DNA through intercalation, as confirmed by absorption, fluorescence, circular dichroism and DNA viscosity measurements. The binding constant (K-b) values ranged from 4.46 to 6.73 x 10(4) M-1.
Article
Chemistry, Inorganic & Nuclear
Alexander M. Brown, Jana L. Butman, Raphael Lengacher, Natasha P. Vargo, Kirsten E. Martin, Angus Koller, Dariusz Smilowicz, Eszter Boros, Jerome R. . Robinson
Summary: Radioisotopes of Cu, including 64Cu and 67Cu, are promising for imaging and radiotherapeutic applications. This study presents the synthesis of a cyclen-based spirocyclic chelate and investigates its stability under physiological conditions and its comparison with other radiopharmaceuticals. The results suggest that N-protonated species are not inherently unstable and N,N-alkylation shows potential as a tool for the rational design of future radiopharmaceuticals.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Gurunath Sahu, Sushree Aradhana Patra, Pratikshya Das Pattanayak, Werner Kaminsky, Rupam Dinda
Summary: In this study, four new oxidovanadium complexes were synthesized and characterized. These complexes showed interactions with DNA and BSA, and exhibited anticancer activity. Among them, complex 2 showed the highest anticancer activity against HT-29 cell line.
INORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Potlapati Varakumar, Kalirajan Rajagopal, Baliwada Aparna, Kannan Raman, Gowramma Byran, Clara Mariana Goncalves Lima, Salma Rashid, Mohammed H. Nafady, Talha Bin Emran, Slawomir Wybraniec
Summary: This review provides a summary of the recent advancements in the chemistry of acridines as anti-cancer agents, including new structural and biologically active attributes. Acridine derivatives are extensively studied as potential anti-cancer drugs. Despite their high cytotoxic activity, the clinical application of acridines is limited or even excluded due to side effects.
Article
Chemistry, Medicinal
Zhen-Feng Wang, Xiao-Feng Zhou, Qiao-Chang Wei, Qi-Pin Qin, Jin-Xian Li, Ming-Xiong Tan, Shu-Hua Zhang
Summary: The four novel bifluorescent Zn(II)-cryptolepine-cyclen complexes showed strong anticancer activity against cisplatin-resistant A549R lung tumor cells, selectively imaging the nucleus and mitochondria of cells while efficiently inhibiting DNA synthesis and causing DNA impairments in the nuclear and mitochondrial fractions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Physical
Nitesh Kumar, Raj Kaushal, Pamita Awasthi
Summary: Transition metal complexes are widely used therapeutic agents due to their small size, various coordination numbers, geometries, physiologically relevant redox potentials, as well as kinetic and thermodynamic stability. These complexes proved to be potential cytotoxic agents by acting on DNA which stops the replication of DNA and ultimately results in cell death.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Medicinal
Daria Rozycka, Aleksandra Kowalczyk, Marta Denel-Bobrowska, Olga Kuzmycz, Magdalena Gapinska, Pawel Staczek, Agnieszka B. Olejniczak
Summary: Synthesis of carborane-modified acridine analogs showed their DNA-binding ability and potential anticancer activities. Compound 30 demonstrated strong interaction with ct-DNA, while compound 29 changed the conformation of ct-DNA. Compound 30 exhibited cytotoxicity, inhibited cell proliferation, arrested the cell cycle, and induced reactive oxygen species production in the HeLa cancer cell line.
Article
Chemistry, Multidisciplinary
P. K. Anuja, Priyankar Paira
Summary: The synthesized Ru(ii)-arene complexes showed higher cytoselectivity and potency in cancer cells, with RuL3 complex exhibiting the highest cytoselectivity and DNA intercalative nature, making it suitable for imaging applications.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Nicholas A. Phillips, Richard Y. Kong, Andrew J. P. White, Mark R. Crimmin
Summary: A series of linear late transition metal complexes with side-on [B=C](-) containing ligands have been isolated and characterized, with comparison showing deviation in coordination modes. Computational techniques were used to analyze bonding and rationalize impacts on substrate activation. The study provides insight into the catalytic relevance of d(10) complexes of Cu, Ag, and Au, highlighting the role of metal variation in coordination modes and substrate activation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Marianna Tosato, Marco Dalla Tiezza, Nora May, Abdirisak Ahmed Isse, Sonia Nardella, Laura Orian, Marco Verona, Christian Vaccarin, Andre Alker, Helmut Macke, Paolo Pastore, Valerio Di Marco
Summary: A series of Cu2+ complexes formed by cyclen derivatives with sulfur pendant arms were studied for their potential as chelators for copper radioisotopes. Various experiments were conducted to evaluate the stoichiometry and stability of these complexes, demonstrating their promising application in copper-based radiopharmaceuticals. The high stability of both Cu2+ and Cu+ complexes suggests these sulfur-containing chelators may prevent in vivo demetalation after bioinduced reduction to Cu+.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zahra Shabaninejad, Maryam Nikkhah, S. Masoud Nabavizadeh
Summary: The DNA binding capacity and cytotoxic effects of two cycloplatinated complexes (C1 and C2) were evaluated. Both complexes exhibited high DNA binding affinity and were able to quench the fluorescence of ethidium bromide. They also induced DNA viscosity increase, confirming their intercalative interactions with DNA. C2 showed the highest cytotoxicity, particularly on a cisplatin resistant-cell line, and induced apoptosis comparable or higher than cisplatin in all cell lines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)