Article
Chemistry, Multidisciplinary
Xin Jiang, Chenguang Yang, Jie Qiu, Dongfei Ma, Cheng Xu, Shuxin Hu, Weijing Han, Bing Yuan, Ying Lu
Summary: LL-37 is able to induce specific permeability of a phosphoethanolamine-rich mitochondrial membrane in a protein-independent manner, offering an alternative pathway for LL-37-triggered mitochondrial membrane permeabilization and apoptosis.
Review
Biochemistry & Molecular Biology
Kornelius Zeth, Enea Sancho-Vaello
Summary: The human cathelicidin LL-37 is a versatile peptide with antimicrobial activity, playing a crucial role in targeting microorganisms. Recent structural studies have revealed the diversity and adaptability of LL-37 in interacting with lipid-like molecules. Complexes of LL-37 with detergents provide insights into mimicking lipids and inducing oligomerization and fibrillation, opening avenues for designing LL-37-derived peptides with enhanced antibiotic properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Piotr Kolesinski, Kuei-Chen Wang, Yujiro Hirose, Victor Nizet, Partho Ghosh
Summary: This study revealed the specific binding mechanism between the Streptococcus pyogenes M protein and the human antimicrobial peptide LL-37, providing important insights into the drug resistance of streptococcus.
Article
Immunology
Shanthini Kalimuthu, Akhila Pudipeddi, Grazyna Bras, Julian A. Tanner, Maria Rapala-Kozik, Yiu Yan Leung, Prasanna Neelakantan
Summary: The study investigated the activity of LL-37-based peptides against Candida albicans. It was found that GK-17, a 17 amino acid peptide, showed remarkable stability to fungal aspartyl proteases and had inhibitory effects on adhesion, biofilm formation, and preformed biofilms. In addition, GK-17 exhibited concentration-dependent biocompatibility to red blood cells.
Article
Medicine, Research & Experimental
Chih-Chin Shih, Wei-Chieh Liao, Hung-Yen Ke, Chia-Wen Kuo, Cheng-Ming Tsao, Wen-Chiuan Tsai, Yi-Lin Chiu, Hsieh-Chou Huang, Chin-Chen Wu
Summary: Global warming increases the incidence of heat stroke, which leads to intestinal barrier disruption, microbial translocation, systemic inflammation, and multiple organ failure. Cathelicidin LL-37 has protective effects on the intestine and could prevent heat stress-induced intestinal damage and heat-related illnesses.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Infectious Diseases
Kylen E. Ridyard, Joerg Overhage
Summary: LL-37 shows promise as an alternative to conventional antibiotics due to its broad spectrum antibacterial and immunomodulatory properties, but faces limitations such as high cost and toxicity to human cells.
Article
Cell Biology
Debabrata Biswas, Poornima Ambalavanan, Miriam Ravins, Aparna Anand, Abhinay Sharma, Kimberly Xuan Zhen Lim, Rachel Ying Min Tan, Hwee Ying Lim, Asaf Sol, Gilad Bachrach, Veronique Angeli, Emanuel Hanski
Summary: Research has shown that Group A Streptococcus can resist host immune responses by cleaving the host's antimicrobial peptide LL-37, leading to soft-tissue infections. Furthermore, the activation of host receptors mediated by LL-37 is critical for defense against GAS infections.
Article
Biochemistry & Molecular Biology
Tomasz Wollny, Urszula Wnorowska, Ewelina Piktel, Lukasz Suprewicz, Grzegorz Krol, Katarzyna Gluszek, Stanislaw Gozdz, Janusz Kopczynski, Robert Bucki
Summary: The role of inflammation in bladder cancer development is still unclear. This study investigates the potential role of sphingosine-1-phosphate (S1P), a regulator of cellular processes in inflammation and cancer, and its effect on the expression of human cathelicidin (hCAP-18). The study suggests that S1P may promote bladder cancer development by stimulating the expression of hCAP-18.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Matthias Keutmann, Gabriele Hermes, Denise Meinberger, Annika Roth, Jannik Stemler, Oliver A. Cornely, Andreas R. Klatt, Thomas Streichert
Summary: Several studies have discussed the beneficial effects of vitamin D on COVID-19 progression. Vitamin D stimulates the expression of the antimicrobial peptide LL-37, which has been shown to antagonize SARS-CoV-2. This study investigated the association between LL-37 and vitamin D serum levels and the severity of COVID-19. The findings suggest that the LL-37/leukocyte count ratio could be used as an indicator to assess the risk of COVID-19 progression at an early stage.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Orsolya Somogyi, Zsolt Dajnoki, Lilla Szabo, Krisztian Gaspar, Zoltan Hendrik, Christos C. Zouboulis, Klaudia Docs, Peter Szucs, Katalin Dull, Daniel Torocsik, Aniko Kapitany, Andrea Szegedi
Summary: By comparing non-lesional HS skin, lesional HS skin, and healthy skin, the study found that none of the investigated molecules were significantly altered in non-lesional HS skin, while 11 molecules changed significantly in lesional HS skin. The study also showed that the permeability barrier function was not significantly damaged in HS skin, and permeability barrier alterations are not the driver factors of keratinocyte activation in this disease.
Article
Biotechnology & Applied Microbiology
Guixi Wang, Zhizhi Chen, Pan Tian, Qinqin Han, Jinyang Zhang, A-Mei Zhang, Yuzhu Song
Summary: Cathelicidin-DM promotes cell proliferation and migration by activating the MAPK signaling pathway, facilitating wound healing. In animal experiments, it accelerates skin wound healing and early debridement, suggesting a new approach for treating infected chronic wounds.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Nagat Siednamohammeddeen, Rehab Badi, Tahane Mohammeddeen, Khalid Enan, AmalSaeed
Summary: This study found that supplementation of Gum Arabic can induce Cathelicidin expression in macrophages, and the effect is dose dependent.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Infectious Diseases
Oriana Simonetti, Oscar Cirioni, Gaia Goteri, Guendalina Lucarini, Elzbieta Kamysz, Wojciech Kamysz, Fiorenza Orlando, Giulio Rizzetto, Elisa Molinelli, Gianluca Morroni, Roberto Ghiselli, Mauro Provinciali, Andrea Giacometti, Annamaria Offidani
Summary: LL-37 has a potential future role in the management of infected wounds, promoting wound healing and angiogenesis.
Review
Biology
Zahra Chinipardaz, Jessica M. Zhong, Shuying Yang
Summary: The goal of regenerative therapy is to restore the structure and function of lost tissues in medicine and dentistry. Challenges such as oxygen and nutrition delivery and infection risk exist. LL-37, a peptide found only in humans, has been shown to play an essential role in neovascularization, stem cell migration and differentiation, and host immune response modulation. It also possesses functions in wound healing, angiogenesis, cell differentiation, and apoptosis modulation.
Article
Chemistry, Multidisciplinary
Johnson John, Navatha Shree Sharma, Guosheng Tang, Zeyu Luo, Yajuan Su, Shelbie Weihs, S. M. Shatil Shahriar, Guangshun Wang, Alec McCarthy, Justin Dyke, Yu Shrike Zhang, Ali Khademhosseini, Jingwei Xie
Summary: This study introduces a strategy to use nanofiber aerogels combined with the LL-37-mimic peptide W379 for accelerated healing of diabetic wounds, showing great potential for clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Fumihito Hasebe, Kenichi Matsuda, Taro Shiraishi, Yushi Futamura, Takeshi Nakano, Takeo Tomita, Ken Ishigami, Hikari Taka, Reiko Mineki, Tsutomu Fujimura, Hiroyuki Osada, Tomohisa Kuzuyama, Makoto Nishiyama
NATURE CHEMICAL BIOLOGY
(2016)
Article
Parasitology
Shinzaburo Takamiya, Muneaki Hashimoto, Toshihiro Mita, Takehiro Yokota, Yoshitaka Nakajima, Fumiyuki Yamakura, Shigetoshi Sugio, Tsutomu Fujimura, Takashi Ueno, Hiroshi Yamasaki
PARASITOLOGY INTERNATIONAL
(2016)
Article
Multidisciplinary Sciences
Kenta Mukaihara, Yoshiyuki Suehara, Shinji Kohsaka, Keisuke Akaike, Yu Tanabe, Daisuke Kubota, Midori Ishii, Tsutomu Fujimura, Saiko Kazuno, Taketo Okubo, Tatsuya Takagi, Takashi Yao, Kazuo Kaneko, Tsuyoshi Saito
Article
Biology
Jorge Morales, Muneaki Hashimoto, Tom A. Williams, Hiroko Hirawake-Mogi, Takashi Makiuchi, Akiko Tsubouchi, Naoko Kaga, Hikari Taka, Tsutomu Fujimura, Masato Koike, Toshihiro Mita, Frederic Bringaud, Juan L. Concepcion, Tetsuo Hashimoto, T. Martin Embley, Takeshi Nara
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2016)
Article
Multidisciplinary Sciences
Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata, Daisuke Yasuda, Kyoko Takahashi, Tsutomu Fujimura, Jingbo Pi, Myung-Shik Lee, Takashi Ueno, Tomoyuki Ohe, Tadahiko Mashino, Toshifumi Wakai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hozumi Motohashi, Satoshi Waguri, Tomoyoshi Soga, Masayuki Yamamoto, Keiji Tanaka, Masaaki Komatsu
NATURE COMMUNICATIONS
(2016)
Article
Oncology
Saiko Kazuno, Jun-ichi Furukawa, Yasuro Shinohara, Kimie Murayama, Makoto Fujime, Takashi Ueno, Tsutomu Fujimura
Article
Multidisciplinary Sciences
Fumiyuki Sasaki, Tomoaki Koga, Kazuko Saeki, Toshiaki Okuno, Saiko Kazuno, Tsutomu Fujimura, Yasuyuki Ohkawa, Takehiko Yokomizo
Article
Multidisciplinary Sciences
Masao Kishimoto, Jun Suenaga, Hajime Takase, Kota Araki, Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Ryu Ueno, Nobuyuki Shimizu, Nobutaka Kawahara, Tetsuya Yamamoto, Yoshinori Seko
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Jun Takai, Hiroshi Ohtsu, Atsushi Sato, Satoshi Uemura, Tsutomu Fujimura, Masayuki Yamamoto, Takashi Moriguchi
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Kei Saito, Takashi Murayama, Tomone Hata, Takuya Kobayashi, Keitaro Shibata, Saiko Kazuno, Tsutomu Fujimura, Takashi Sakurai, Yoko Y. Toyoshima
MOLECULAR BIOLOGY OF THE CELL
(2020)
Article
Chemistry, Medicinal
Sachiko Komatsu, Ken-ichi Ohno, Tsutomu Fujimura
CHEMICAL & PHARMACEUTICAL BULLETIN
(2020)
Article
Polymer Science
Kazuhiro Watanabe, Kyoko Sugiyama, Sachiko Komatsu, Kentaro Yoshida, Tetsuya Ono, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato
Article
Polymer Science
Kentaro Yoshida, Akane Yamaguchi, Hiroki Midorikawa, Toshio Kamijo, Tetsuya Ono, Takenori Dairaku, Takaya Sato, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato
Article
Chemistry, Multidisciplinary
Tetsuya Ono, Kyoko Sugiyama, Sachiko Komatsu, Masayuki Kumano, Kentaro Yoshida, Takenori Dairaku, Tsutomu Fujimura, Yusuke Sasano, Yoshiharu Iwabuchi, Yoshitomo Kashiwagi, Katsuhiko Sato
Summary: This study demonstrated the quantification of vancomycin and other antibiotics using electrochemical methods with nitroxyl radicals as electrocatalysts. NNO was found to be more active than TEMPO but inactivated by primary amines, leading to the use of A-TEMPO for detecting vancomycin. The method showed promising results in quantifying vancomycin in the concentration range of 10-100 µM, important for drug monitoring in blood.
Article
Chemistry, Medicinal
Motoyasu Kato, Fumiyuki Takahashi, Tadashi Sato, Yoichiro Mitsuishi, Ken Tajima, Hiroaki Ihara, Fariz Nurwidya, Hario Baskoro, Akiko Murakami, Isao Kobayashi, Moulid Hidayat, Naoko Shimada, Shinichi Sasaki, Reiko Mineki, Tsutomu Fujimura, Toshio Kumasaka, Shin-ichiro Niwa, Kazuhisa Takahashi
DRUG DESIGN DEVELOPMENT AND THERAPY
(2020)