Article
Microbiology
Seema Shetty, Renuka Anegundi, Padmaja Ananth Shenoy, Shashidhar Vishwanath
Summary: This study aimed to analyze the role of F. magna in clinical infections and evaluate their antimicrobial susceptibility. Antimicrobial susceptibility testing was performed on 42 clinical isolates of F. magna, and it was found that all isolates showed good susceptibility to metronidazole, cefoxitin, linezolid, and chloramphenicol. Resistance to clindamycin and penicillin was observed in 9.5% and 2.4% of isolates, respectively, but no beta-lactamase activity was detected.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Medicine, General & Internal
Nimisha Thomas, Dipali Taggarsi, Prudhvi Dasari, Roger Rathna
Summary: Necrotizing fasciitis is a highly invasive disease characterized by rapidly worsening inflammation of the fascia associated with necrosis of the subcutaneous tissue. Early diagnosis and urgent surgical management are essential to prevent the potentially fatal consequences of this rare disease. This case report highlights the importance of clinical awareness and prompt treatment in managing necrotizing soft tissue infections.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Immunology
Xia Li, Youyuan Ye, Kailan Peng, Zhuo Zeng, Li Chen, Yanhua Zeng
Summary: Histones, highly conserved in different species, serve as an ancient and universal innate host defense system against microorganisms. They act as a control switch for DNA transcription in the nucleus, but also function in the cytoplasm, cell membranes, and extracellular fluid as host defenses and inflammatory promoters. Histones can eliminate microorganisms directly and participate in phagocytes-related innate immune responses, while also playing a crucial role in epigenetic regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xue Wan, Shuang Wang, Min Wang, Jinhua Liu, Yu Zhang
Summary: This study reports a case of Peptoniphilus harei bacteremia in an abdominal aortic aneurysm patient, highlighting the importance of including anaerobic blood cultures as part of blood culture procedures. Clinical microbiologists should be vigilant that the pathogenic potential of GPAC may be underestimated.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Nuhamin Melaku Gebremariam, Adane Bitew, Estifanos Tsige, Daniel Woldesenbet, Mekdes Alemu Tola
Summary: The study revealed high levels of antimicrobial resistance and multi-drug resistance in Gram-positive cocci, highlighting the importance of ongoing monitoring of resistance patterns for selecting appropriate drugs for treatment and infection prevention.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Mar de Pablo-Miro, Sergi Pujol-Ruiz, Simona Iftimie, Maria del Mar Arenas-Miras, Inmaculada Lopez-Montesinos, Xavier Duran-Jorda, Albert Angles, Santiago Grau, Juan P. Horcajada
Summary: Dalbavancin, a new antibiotic effective against Gram-positive microorganisms, offers the possibility of weekly IV therapy in outpatient setting. A case-control study showed that Dalbavancin treatment reduced hospital stay and improved 30-day efficacy compared to other antibiotics.
Article
Infectious Diseases
Patrizia Ferraboschi, Samuele Ciceri, Paride Grisenti
Summary: Lysozyme is a 14 kDa protein found in mucosal secretions and tissues of animals and plants, playing a key role in innate immunity by protecting against bacteria, viruses, and fungi. It is known to have antimicrobial properties and has been studied for various applications as an alternative antibiotic in medicine, veterinary, and food preservation industries. The synergistic effects of lysozyme with other antimicrobial compounds are also highlighted in this review.
Article
Infectious Diseases
Yongli Wei, He Zhang, Maowu Fu, Rui Ma, Ronghui Li, Lingti Kong
Summary: This study aimed to analyze the pharmacokinetics/pharmacodynamics (PK/PD) of linezolid in patients with intracerebral hemorrhage and provide recommendations for dosing and treatment regimens. The study found that linezolid had high target attainment probability (PTA) in plasma and sputum when the minimum inhibitory concentration (MIC) was <= 1 mg/L. Linezolid showed the highest cumulative fraction of response (CFR) against Streptococcus pneumoniae, followed by Enterococcus faecalis and Enterococcus faecium, with the lowest value for MRSA. This study provides valuable insights for selecting appropriate dosing regimens for linezolid in patients with intracerebral hemorrhage.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Immunology
Wei-Feng Wang, Xiao-Yong Xie, Kang Chen, Xiu-Li Chen, Wei-Lin Zhu, Huan-Ling Wang
Summary: The Chinese horseshoe crab relies on its innate immune system for pathogen defense, but the specific mechanisms underlying its abilities to distinguish and defend against invading microbes are still unclear. Through high-throughput sequencing and bioinformatics analysis, this study identified key signaling pathways activated in the Chinese horseshoe crab's hemolymph in response to Gram-negative bacteria, shedding light on the ancient original innate immune mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Le Wang, Xiaohong Pan, Shuzhi Tang, Yaqi Wang, Haixing Shi, Huanhuan Wang, Wenzhen Liu, Zhuo Chen
Summary: The skin microbiota is an important component of the skin barrier and plays a role in the stability of the barrier function and the development of skin diseases. Researchers have developed a negatively charged photosensitizer TPA-3NBA that can selectively stain and effectively kill Gram-positive cocci, allowing for quick identification of bacterial infections.
Article
Biochemistry & Molecular Biology
Edith Reuschel, Martina Toelge, Sebastian Haeusler, Ludwig Deml, Birgit Seelbach-Goebel, Maria Emilia Solano
Summary: This study highlights the importance of cytokine responses to bacterial infections during pregnancy, particularly in the pathogenesis of preterm birth and neonatal sepsis. The results suggest that IL-8 may be a valuable diagnostic marker for timely detection of infections in preterm neonates, and that MIP-1 beta could play a role in sex-specific immunity and vulnerability to preterm birth in males.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Travis B. Nielsen, Jun Yan, Brian M. Luna, Yuli Talyansky, Matthew Slarve, Robert A. Bonomo, Brad Spellberg
Summary: Research shows that antibacterial monoclonal antibody therapy enhances macrophage phagocytosis and rescues mice from lethal infections by utilizing complement, macrophages, and neutrophils. The level of bacterial burden does not directly correlate with survival. Furthermore, modulation of proinflammatory and anti-inflammatory cytokines is crucial for improving survival rates in antibody therapy against bacterial infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Richard G. Wunderink, Antoine Roquilly, Martin Croce, Daniel Rodriguez Gonzalez, Satoshi Fujimi, Joan R. Butterton, Natasha Broyde, Myra W. Popejoy, Jason Y. Kim, Carisa De Anda
Summary: Tedizolid demonstrated noninferiority to linezolid in terms of day 28 all-cause mortality in the treatment of gram-positive ventilated HABP/VABP, but noninferiority was not demonstrated for investigator-assessed clinical cure at test of cure. Both drugs were well tolerated.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Stefan Miladinov Kovachev
Summary: This review examined and summarized the use of inosine pranobex (IP) immunotherapy in cervical HPV-positive patients. It was found that IP has antiviral efficacy, enhances host antiviral activity against HPV, and helps prevent disease progression and clear the pathogen.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biochemistry & Molecular Biology
Manoj Reddy Medapati, Anjali Yadav Bhagirath, Nisha Singh, Robert J. Schroth, Rajinder P. Bhullar, Kangmin Duan, Prashen Chelikani
Summary: The study reveals distinct roles of T2R14 in internalization and growth inhibition of S. mutans and S. aureus, with knockdown of T2R14 leading to decreased internalization of S. aureus. Pre-treatment of GECs with S. mutans CSP-1 inhibits the growth of S. aureus while not affecting S. mutans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Elizabeth C. Murphy, Robert Janulczyk, Christofer Karlsson, Matthias Moergelin, Inga-Maria Frick
Article
Microbiology
Roibeard F. Thornton, Elizabeth C. Murphy, Todd F. Kagawa, Paul W. O'Toole, Jakki C. Cooney
Article
Microbiology
Elizabeth C. Murphy, Matthias Morgelin, Jakki C. Cooney, Inga-Maria Frick
Article
Biochemistry & Molecular Biology
Elizabeth C. Murphy, Matthias Morgelin, Dieter P. Reinhardt, Anders I. Olin, Lars Bjorck, Inga-Maria Frick
MOLECULAR MICROBIOLOGY
(2014)
Review
Microbiology
Elizabeth Carmel Murphy, Inga-Maria Frick
FEMS MICROBIOLOGY REVIEWS
(2013)