期刊
JOURNAL OF INNATE IMMUNITY
卷 4, 期 2, 页码 213-218出版社
KARGER
DOI: 10.1159/000329550
关键词
Toll-like receptor 9; Group A Streptococcus; Innate immunity
类别
资金
- Swiss National Foundation [SSMBS PASMA117303/1, PASMA-114623, PASM33-117302]
- National Institutes of Health [AI77780, AI077989]
- Deutsche Akademie der Naturforscher Leopoldina [BMBF-LPD 9901/8-187]
Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-la levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models. Copyright (C) 2012 S. Karger AG, Basel
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