期刊
JOURNAL OF INNATE IMMUNITY
卷 2, 期 5, 页码 395-405出版社
KARGER
DOI: 10.1159/000314077
关键词
Facultative heterochromatin; Gene-specific reprogramming; Septic shock; Leukocytes; NF kappa B RelB; Histone code; Nucleosome positioning
类别
资金
- NIH [RO1 AI-09169, RO1 AI-065791, R01 AI-079144]
- WFU General Clinical Research Center [MO-1RR 007122]
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR007122] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI065791, R01AI079144, R01AI009169] Funding Source: NIH RePORTER
Inflammation is a fundamental biologic process that is evolutionally conserved by a germ line code. The interplay between epigenetics and environment directs the code into temporally distinct inflammatory responses, which can be acute or chronic. Here, we discuss the epigenetic processes of innate immune cells during serious infections with systemic inflammation in four stages: homeostasis, incitement, evolution, and resolution. We describe feed-forward loops of serious infections with systemic inflammation that create gene-specific silent facultative heterochromatin and active euchromatin according to gene function, and speculate on the role of epigenetics in survival. Copyright (C) 2010 S. Karger AG, Basel
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