期刊
JOURNAL OF INNATE IMMUNITY
卷 1, 期 5, 页码 435-445出版社
KARGER
DOI: 10.1159/000226248
关键词
Infectious diseases; Innate immunity; Pathogen-associated molecular patterns; Pattern recognition; Toll-like receptor; Viral infection; Virus-host cell interactions
类别
资金
- NIH [AI057568]
- Pacific Northwest Regional Center for Excellence
- State of Washington
- Washington University School of Medicine
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI057568] Funding Source: NIH RePORTER
As a first line of defense after viral infection, host cells develop an intrinsic immune response to control virus dissemination and protect against serious infection. Recent experiments have shown a dominant role of the IFN-alpha/beta response in protection against lethal West Nile virus (WNV) by limiting the cellular and tissue tropism of infection. This review will focus on advances in identifying the host sensors that detect WNV and the adaptor molecules and signaling pathways that regulate the induction of IFN-alpha/beta defenses that limit WNV replication, spread and pathogenesis. Copyright (C) 2009 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
