Article
Clinical Neurology
Jianqiao Tian, Sheelakumari Raghavan, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Robel K. Gebre, Jonathan Graff-Radford, Christopher G. Schwarz, Val J. Lowe, Kejal Kantarci, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Prashanthi Vemuri
Summary: This study used neurite orientation dispersion and density imaging (NODDI) to investigate the association between white matter (WM) changes and Alzheimer disease (AD), and evaluated its relationship with cognitive performance. The results showed that the neurodegeneration of WM is spatially dependent and correlated with regional tau deposition in different stages of AD. Additionally, the WM changes explained a similar amount of cognitive performance variation as regional tau deposition and provided complementary information about disease staging and progression.
Article
Clinical Neurology
Marek J. Konieczny, Anna Dewenter, Annemieke ter Telgte, Benno Gesierich, Kim Wiegertjes, Sofia Finsterwalder, Anna Kopczak, Mathias Huebner, Rainer Malik, Anil M. Tuladhar, Jose P. Marques, David G. Norris, Alexandra Koch, Olaf Dietrich, Michael Ewers, Reinhold Schmidt, Frank-Erik de Leeuw, Marco Duering
Summary: The study demonstrated that DKI metrics had the strongest associations with processing speed performance in patients with cerebral small vessel disease. DTI and DKI metrics performed similarly in detecting disease progression, while NODDI metrics showed poorer reproducibility.
Article
Radiology, Nuclear Medicine & Medical Imaging
Menno D. Stellingwerff, Murtadha L. Al-Saady, Tim van de Brug, Frederik Barkhof, Petra J. W. Pouwels, Marjo S. van der Knaap
Summary: According to the study, there are variations in the nature and progression of cerebral white matter abnormalities in patients with vanishing white matter (VWM) based on their age at onset. Patients with later onset have slower white matter decay, but exhibit more significant white matter atrophy and gliosis.
Article
Neurosciences
Shalin A. A. Parekh, Jamie Wren-Jarvis, Maia Lazerwitz, Mikaela A. A. Rowe, Rachel Powers, Ioanna Bourla, Lanya T. T. Cai, Robyn Chu, Kaitlyn Trimarchi, Rafael Garcia, Elysa J. J. Marco, Pratik Mukherjee
Summary: Diffusion tensor imaging (DTI) studies have revealed white matter microstructural differences between the left and right hemispheres of the brain. This study aimed to understand the biophysical properties underlying these hemispheric asymmetries, particularly in children, and investigate whether similar asymmetries exist in sensory processing disorder (SPD). The results show that biophysical modeling of diffusion MRI (dMRI) can explain the observed hemispheric asymmetries, and sensory over-responsivity (SOR) in children with SPD is associated with increased lateralization in several brain tracts.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Eva-Maria Stauffer, Richard A. Bethlehem, Varun Warrier, Graham K. Murray, Rafael Romero-Garcia, Jakob Seidlitz, Edward T. Bullmore
Summary: The study found associations between polygenic risk scores and neuroimaging phenotypes, suggesting genetic effects on brain structure at global and regional scales. Results indicate a link between genetic risk for schizophrenia and altered neurite density index in the brain.
MOLECULAR PSYCHIATRY
(2021)
Article
Cell Biology
Yun-Qing Luo, Rong-Bin Liang, San-Hua Xu, Yi-Cong Pan, Qiu-Yu Li, Hui-Ye Shu, Min Kang, Pin Yin, Li-Juan Zhang, Yi Shao
Summary: This study investigated regional changes in brain white matter in dry eye patients using DTI and NODDI. The results showed significant differences in FA, MD, and ODI between dry eye patients and healthy controls, suggesting potential pathological mechanisms underlying dry eye.
Article
Clinical Neurology
Christina Mueller, Adam M. Goodman, Jane B. Allendorfer, Rodolphe Nenert, Tyler E. Gaston, Leslie E. Grayson, Stephen Correia, Noah S. Philip, W. Curt LaFrance, Jerzy P. Szaflarski
Summary: This study aimed to quantify changes in white matter morphology using neurite orientation dispersion and density imaging (NODDI) after neurobehavioral therapy (NBT) for functional seizures (FS). The results showed that patients with FS exhibited white matter plasticity in specific regions, which correlated with improvements in psychosocial functioning. NODDI could be considered for future assessments of interventions in patients with FS.
ANNALS OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Xiaochen Zhang, Jiajia Zhou, Yongjun Chen, Lei Guo, Zhi Yang, Trevor W. Robbins, Qing Fan
Summary: This study used multimodal brain imaging to examine the dendritic morphology in patients with OCD and found that they exhibited altered neurite microstructure and classic morphometries compared to healthy controls. These alterations were interconnected into a pathological brain network associated with OCD symptoms. The findings highlight the importance of in vivo imaging in understanding OCD and developing biomarkers for this disorder.
Article
Neurosciences
Chengzhe Zhang, Yuan Yuan, Tian Sang, Lihua Yu, Yan Yu, Xiaoming Liu, Wenyang Zhou, Qingrun Zeng, Jingqiang Wang, Guoping Peng, Yuanjing Feng
Summary: Mild cognitive impairment is a common complication in Parkinson's disease (PD), with a high risk of dementia. Previous studies using diffusion tensor imaging (DTI) lacked specificity and consistency in characterizing white matter alterations. This study used a more specific imaging technique, neurite orientation dispersion and density imaging (NODDI), to uncover local white matter abnormalities in PD-MCI. The results showed significantly lower neurite density and orientation dispersion in the prefrontal white matter in PD-MCI patients. The NODDI-derived metrics also showed superior diagnostic performance compared to DTI metrics. This study contributes to our understanding of the underlying mechanism of cognitive decline in PD and has potential implications for early disease prediction.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Neurosciences
Ian T. Mark, Jamie Wren-Jarvis, Jaclyn Xiao, Lanya T. Cai, Shalin Parekh, Ioanna Bourla, Maia C. Lazerwitz, Mikaela A. Rowe, Elysa J. Marco, Pratik Mukherjee
Summary: In this study, the white matter microstructure of boys with Sensory Processing Dysfunction (SPD) and Attention Deficit and Hyperactivity Disorder (ADHD) was found to be more impaired compared to boys with only SPD, as shown by diffusion tensor imaging (DTI) and Neurite Orientation Dispersion and Density Imaging (NODDI) analysis.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neuroimaging
Christina Mueller, Jerzy P. Szaflarski
Summary: This study investigated the relationship between neuroinflammation and psychogenic non-epileptic seizures (PNES). The results showed no differences in white matter microstructure between PNES patients and individuals with psychiatric conditions. However, there were associations between inflammatory biomarkers and specific brain regions in PNES patients. These findings suggest that peripheral inflammatory biomarkers may be a useful aid for PNES diagnosis.
NEUROIMAGE-CLINICAL
(2023)
Article
Neuroimaging
Debbie Anaby, Shai Shrot, Eugenia Belenky, Bruria Ben-Zeev, Michal Tzadok
Summary: This study found that advanced diffusion MRI can identify widespread white matter alterations in patients with tuberous sclerosis complex (TSC). Neurite density was significantly correlated with disease severity, suggesting its potential as a biomarker for TSC.
NEUROIMAGE-CLINICAL
(2022)
Article
Nutrition & Dietetics
Yuji Ueno, Asami Saito, Junichiro Nakata, Koji Kamagata, Daisuke Taniguchi, Yumiko Motoi, Hiroaki Io, Christina Andica, Atsuhiko Shindo, Kenta Shiina, Nobukazu Miyamoto, Kazuo Yamashiro, Takao Urabe, Yusuke Suzuki, Shigeki Aoki, Nobutaka Hattori
Summary: The study investigated white-matter microstructural changes and cognitive decline in hemodialysis patients using novel dMRI techniques. Long-term treatment with l-carnitine may alleviate white-matter microstructural damage and improve cognitive impairment in this population.
Article
Neurosciences
T. Demerath, C. Donkels, M. Reisert, M. Heers, A. Rau, N. Schroeter, A. Schulze-Bonhage, P. Reinacher, C. Scheiwe, M. J. Shah, J. Beck, A. Vlachos, C. A. Haas, H. Urbach
Summary: Hippocampal sclerosis with gray-white matter blurring in the anterior temporal lobe is associated with prolonged T1 relaxation and axonal loss. Patients without GMB in the temporal poles showed less reduction in axonal fraction on imaging compared to normal controls. Contralateral values did not differ significantly between patients and normal controls, but reduced axonal density and diameter were confirmed in the GMB-affected temporopolar white matter compared to temporal poles without GMB.
Article
Clinical Neurology
Keejin Yoon, Derek B. Archer, Margareta A. Clarke, Seth A. Smith, Ipek Oguz, Gary Cutter, Junzhong Xu, Francesca Bagnato
Summary: In this study, the researchers propose that using the NODDI method and high-resolution probabilistic tractography, white matter tract templates can improve the assessment of regional axonal injury and its association with disability in pwMS. The results show that changes in IVF values are related to the disability status and lesion burden in pwMS.
FRONTIERS IN NEUROLOGY
(2022)
Editorial Material
Biochemical Research Methods
Prashant S. Emani, Jonathan Warrell, Alan Anticevic, Stefan Bekiranov, Michael Gandal, Michael J. McConnell, Guillermo Sapiro, Alan Aspuru-Guzik, Justin T. Baker, Matteo Bastiani, John D. Murray, Stamatios N. Sotiropoulos, Jacob Taylor, Geetha Senthil, Thomas Lehner, Mark B. Gerstein, Aram W. Harrow
Summary: Quantum computing, leveraging the unique properties of quantum mechanics, addresses the challenges of scale and complexity in biological sciences and facilitates the integration of insights across different areas.
Article
Neurosciences
Michiel Cottaar, Matteo Bastiani, Nikhil Boddu, Matthew F. Glasser, Suzanne Haber, David C. van Essen, Stamatios N. Sotiropoulos, Saad Jbabdi
Summary: Many brain imaging studies measure structural connectivity with diffusion tractography, but biases in the data can limit accuracy. A new algorithm reduces these biases by modeling fiber density and orientation.
Article
Multidisciplinary Sciences
Luke Baxter, Fiona Moultrie, Sean Fitzgibbon, Marianne Aspbury, Roshni Mansfield, Matteo Bastiani, Richard Rogers, Saad Jbabdi, Eugene Duff, Rebeccah Slater
Summary: Studying the neurophysiology of neonatal responses to noxious stimulation can predict brain responses and their associations with white matter structure. The research shows that brain activity evoked by noxious stimulation in healthy neonates is linked to resting-state activity and white matter microstructure, providing valuable insights for early life pain management.
NATURE COMMUNICATIONS
(2021)
Review
Anesthesiology
Jente Bontinck, Dorine Lenoir, Barbara Cagnie, Carlos Murillo, Inge Timmers, Elise Cnockaert, Lisa Bernaers, Mira Meeus, Iris Coppieters
Summary: Studies have shown that alterations in pain processing occur soon after whiplash injury, with most patients recovering within 3 months. Those who do not recover within this time frame show little improvement in the following years. Quantitative Sensory Testing (QST) can help differentiate between recovering and non-recovering patients early on, making it a valuable tool in identifying high-risk individuals for chronic pain development.
EUROPEAN JOURNAL OF PAIN
(2022)
Editorial Material
Anesthesiology
Marina Lopez-Sola, Maria Sunol, Inge Timmers
Article
Geriatrics & Gerontology
Jivesh Ramduny, Matteo Bastiani, Robin Huedepohl, Stamatios N. Sotiropoulos, Magdalena Chechlacz
Summary: This study used a multimodal approach to investigate the link between inadequate sleep and accelerated brain aging. The findings indicate significant associations between sleep quality, brain age delta, and inadequate sleep.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Chantal M. W. Tax, Matteo Bastiani, Jelle Veraart, Eleftherios Garyfallidis, M. Okan Irfanoglu
Summary: This review covers the artifacts and preprocessing steps of diffusion MRI (dMRI), highlighting some previously overlooked or recently addressed issues. It focuses on the advancements made since the Human Connectome Project (HCP) in 2013, including the development of novel strategies, open source tools, reproducible pipelines, databases, simulation tools, and automated quality control frameworks for dMRI preprocessing.
Article
Neurosciences
A. David Edwards, Daniel Rueckert, Stephen M. Smith, Samy Abo Seada, Amir Alansary, Jennifer Almalbis, Joanna Allsop, Jesper Andersson, Tomoki Arichi, Sophie Arulkumaran, Matteo Bastiani, Dafnis Batalle, Luke Baxter, Jelena Bozek, Eleanor Braithwaite, Jacqueline Brandon, Olivia Carney, Andrew Chew, Daan Christiaens, Raymond Chung, Kathleen Colford, Lucilio Cordero-Grande, Serena J. Counsell, Harriet Cullen, John Cupitt, Charles Curtis, Alice Davidson, Maria Deprez, Louise Dillon, Konstantina Dimitrakopoulou, Ralica Dimitrova, Eugene Duff, Shona Falconer, Seyedeh-Rezvan Farahibozorg, Sean P. Fitzgibbon, Jianliang Gao, Andreia Gaspar, Nicholas Harper, Sam J. Harrison, Emer J. Hughes, Jana Hutter, Mark Jenkinson, Saad Jbabdi, Emily Jones, Vyacheslav Karolis, Vanessa Kyriakopoulou, Gregor Lenz, Antonios Makropoulos, Shaihan Malik, Luke Mason, Filippo Mortari, Chiara Nosarti, Rita G. Nunes, Camilla O'Keeffe, Jonathan O'Muircheartaigh, Hamel Patel, Jonathan Passerat-Palmbach, Maximillian Pietsch, Anthony N. Price, Emma C. Robinson, Mary A. Rutherford, Andreas Schuh, Stamatios Sotiropoulos, Johannes Steinweg, Rui Pedro Azeredo Gomes Teixeira, Tencho Tenev, Jacques-Donald Tournier, Nora Tusor, Alena Uus, Katy Vecchiato, Logan Z. J. Williams, Robert Wright, Julia Wurie, Joseph V. Hajnal
Summary: The Developing Human Connectome Project is an open science resource that provides researchers with data on typical and atypical brain development during the perinatal period. With a collection of MRI brain datasets and collateral data from fetal and neonatal participants, this project offers valuable insights into brain development.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Raphaela Muri, Stephanie Maissen-Abgottspon, Christian Rummel, Michael Rebsamen, Roland Wiest, Michel Hochuli, Bernadette M. Jansma, Roman Trepp, Regula Everts
Summary: Despite good metabolic control in childhood and adolescence, adults with phenylketonuria (PKU) often show thinner cortex in several brain regions, which is not related to metabolic parameters or cognitive performance.
JOURNAL OF INHERITED METABOLIC DISEASE
(2022)
Article
Neurosciences
Hannah Bernhard, Frederic L. W. V. J. Schaper, Marcus L. . F. Janssen, Erik D. Gommer, Bernadette M. Jansma, Vivianne Van Kranen-Mastenbroek, Rob P. W. Rouhl, Peter de Weerd, Joel Reithler, Mark J. Roberts
Summary: In this study, sleep spindles were investigated through thalamic recordings, revealing systematic coordination of multichannel spindle patterns at both thalamic and thalamocortical levels. Different subtypes of spindles were associated with distinct topographical patterns of thalamocortical spindle overlap.
Article
Multidisciplinary Sciences
Shaun Warrington, Elinor Thompson, Matteo Bastiani, Jessica Dubois, Luke Baxter, Rebeccah Slater, Saad Jbabdi, Rogier B. Mars, Stamatios N. Sotiropoulos
Summary: This study proposes a novel framework that integrates structural connectivity maps from humans and nonhuman primates onto a common space, allowing the study of divergences and similarities in connectivity over evolutionary and developmental scales to reveal brain maturation trajectories.
Article
Neurosciences
Alexandra K. Emmendorfer, Milene Bonte, Bernadette M. Jansma, Sonja A. Kotz
Summary: Several theories suggest that anticipated events lead to reduced sensory and neural responses. A study using M/EEG found that self-generated events elicited weaker auditory responses compared to externally generated events. In this study, the researchers investigated the sensitivity of N1 and P2 responses to statistical speech regularities. They found that the strength of the responses depended on syllable stress and task demands.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Theo J. M. Kluskens, Peter A. W. H. Kessler, Bernadette M. Jansma, Amanda Kaas, Vincent van de Ven
Summary: This study used fMRI to measure brain activity in patients with bruxism and TMD-related pain compared to healthy controls. The results showed that patients reported more pain during strong teeth clenching and there were significant differences in brain activity in pain processing areas between patients and controls. However, there were no differences in activity in motor-related areas between groups.
JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE
(2023)
Article
Clinical Neurology
Peter Foley, Yazhuo Kong, Ramune Dirvanskiene, Maria Valdes-Hernandez, Matteo Bastiani, Jonathan Murnane, Robin Sellar, Neil Roberts, Cyril Pernet, Christopher Weir, Thomas Bak, Lesley Colvin, Siddharthan Chandran, Marie Fallon, Irene Tracey
Summary: This study reports the dysfunction of descending pain modulation in multiple sclerosis patients with chronic neuropathic pain, showing reduced functional connectivity in specific brain structures and executive dysfunction. The findings highlight the close relationship between cognition, functioning of the descending pain modulatory system, and chronic pain conditions, providing insights for potential pharmacological and cognitive interventions.
BRAIN COMMUNICATIONS
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Ruizhe Li, Matteo Bastiani, Dorothee Auer, Christian Wagner, Xin Chen
Summary: This paper proposes a brain age estimation method based on generative adversarial network, which integrates a task-guided branch to improve model performance and achieves excellent results on a public dataset.
MEDICAL IMAGE UNDERSTANDING AND ANALYSIS (MIUA 2021)
(2021)