Article
Gastroenterology & Hepatology
Bradley G. Goodyear, Faranak Heidari, Richard J. M. Ingram, Filomeno Cortese, Nastaran Sharifi, Gilaad G. Kaplan, Christopher Ma, Remo Panaccione, Keith A. Sharkey, Mark G. Swain
Summary: Magnetic resonance imaging revealed structural and functional changes within the brains of inflammatory bowel disease patients, in regions known to be involved in processing brain signals associated with behavioral symptoms, anxiety, pain, stress, and cognitive deficits.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Neurosciences
Joshua Barry, Minh T. N. Bui, Michael S. Levine, Carlos Cepeda
Summary: Huntington's disease is a heritable and fatal neurodegenerative disorder caused by a mutation in the Huntingtin gene, leading to chorea and cognitive/psychiatric symptoms. Studies suggest that synaptic disconnection, particularly along excitatory pathways, is pervasive in HD, highlighting the critical role of the huntingtin protein in synaptic transmission.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Jinnan Gong, Sisi Jiang, Zhiliang Li, Haonan Pei, Qifu Li, Dezhong Yao, Cheng Luo
Summary: This study utilized diffusion and functional MRI to investigate the pathoglytic changes in the basal ganglia-thalamocortical and cerebellum-thalamocortical pathways in people with idiopathic generalized epilepsy (IGE). The findings revealed connectivity changes with perception and cognition systems and identified abnormal integration of sensorimotor and visual information in IGE. Aberrant functional and structural integration of cerebellum, basal ganglia, and thalamus were linked to cognitive impairment and epileptic activities in IGE.
HUMAN BRAIN MAPPING
(2021)
Article
Psychology, Clinical
Robin Emsley, Stefan du Plessis, Lebogang Phahladira, Hilmar K. Luckhoff, Frederika Scheffler, Sanja Kilian, Retha Smit, Chanelle Buckle, Bonginkosi Chiliza, Laila Asmal
Summary: This study investigated the effects of antipsychotic treatment on brain structural changes in schizophrenia. The results showed plasticity in white matter and basal ganglia associated with antipsychotic treatment, possibly due to the dopamine blocking actions of these drugs. Cortical changes were more closely related to the neurodevelopmental aspects of the illness.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Patrick Forny, Friederike Hoerster, Diana Ballhausen, Anupam Chakrapani, Kimberly A. Chapman, Carlo Dionisi-Vici, Marjorie Dixon, Sarah C. Gruenert, Stephanie Grunewald, Goknur Haliloglu, Michel Hochuli, Tomas Honzik, Daniela Karall, Diego Martinelli, Femke Molema, Joern Oliver Sass, Sabine Scholl-Buergi, Galit Tal, Monique Williams, Martina Huemer, Matthias R. Baumgartner
Summary: This article summarizes the latest guidelines for isolated methylmalonic acidaemia (MMA) and propionic acidaemia (PA), providing a more concise version through an expert panel evaluation and compilation of recommendations to assist healthcare professionals in making informed decisions in patient care.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Neurosciences
Najratun Nayem Pinky, Chantel T. Debert, Sean P. Dukelow, Brian W. Benson, Ashley D. Harris, Keith O. Yeates, Carolyn A. Emery, Bradley G. Goodyear
Summary: Magnetic resonance imaging (MRI) can provide various measurements related to sport-related concussion (SRC) symptoms. In this study, researchers used multimodal MRI and a symptom-guided region-of-interest (ROI) approach to study youth with SRC. They found different MRI changes in the cerebellum, basal ganglia, and white matter tracts in SRC patients compared to controls, which were associated with symptom severity and time since injury. These findings contribute to a better understanding of the physiological mechanisms of concussion and localization of brain injury.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Neurosciences
Sadegh Ghaderi, Seyed Amir Hossein Batouli, Sana Mohammadi, Farzad Fatehi
Summary: QSM is a sensitive MRI biomarker that can evaluate iron levels in subcortical regions of ALS patients. In this study, magnetic susceptibility values were quantitatively analyzed in the putamen regions of an ALS patient, revealing increased values indicative of iron overload. The review of previous QSM studies in ALS further supported the finding of iron dysregulation in subcortical nuclei.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Alison R. Weiss, Zheng Liu, Xiaojie Wang, William A. Liguore, Christopher D. Kroenke, Jodi L. McBride
Summary: Macaques are widely used in neuroscience research, and a brain atlas was created from 18 adult rhesus macaques to better define brain regions across multiple imaging modalities. The atlas includes templates for macroscopic brain structure and diffusion imaging, allowing consistent identification of regions in different imaging modalities.
Article
Neurosciences
Dongning Su, Zhijin Zhang, Zhe Zhang, Yawen Gan, Yingkui Zhang, Xinyao Liu, Jingfeng Bi, Lingyan Ma, Huiqing Zhao, Xuemei Wang, Zhan Wang, Huizi Ma, Shairy Sifat, Junhong Zhou, Wei Li, Tao Wu, Jing Jing, Tao Feng
Summary: This study investigates the relationship between magnetic susceptibility changes and other microstructural and functional alterations in subcortical nuclei of Wilson's disease patients. It also explores the diagnostic utility of these MRI-related metrics. Results show that Wilson's disease patients exhibit increased susceptibility, widespread atrophy, and microstructural impairments in the basal ganglia. The study concludes that microstructural impairment of the basal ganglia and brain atrophy are useful neuroimaging biomarkers for assessing neurological impairment in Wilson's disease.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Rong Li, Ting Zou, Xuyang Wang, Hongyu Wang, Xiaofei Hu, Fangfang Xie, Li Meng, Huafu Chen
Summary: Parkinson's disease is a progressive neurodegenerative disease characterized by both motor and non-motor symptoms. Research suggests that as the disease progresses, gray matter atrophy in Parkinson's patients spreads from the basal ganglia to other brain regions, potentially playing a key role in motor and non-motor circuits.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Xiali Shao, Siyuan Fan, Huan Luo, Ting Yat Wong, Weihong Zhang, Hongzhi Guan, Anqi Qiu
Summary: The study characterized MRI features of anti-LGI1 encephalitis, finding hippocampus and amygdala as lesion hubs, basal ganglia lesions associated with faciobrachial dystonic seizures, and medial temporal lobe lesions correlated with memory impairment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Mikhail Votinov, Katharina S. Goerlich, Andrei A. Puiu, Elke Smith, Thomas Nickl-Jockschat, Birgit Derntl, Ute Habel
Summary: This study found associations between sexual orientation and brain structure characteristics, which differ between genders. It highlights the importance of considering or controlling for potential effects of participants' sexual orientation in neuroimaging studies.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Jae-Hyuk Shim, Hyeon-Man Baek
Summary: In this study, diffusion measures of basal ganglia structures and tracts were compared in newly diagnosed Parkinson's disease patients, revealing significant differences in certain structures or tracts. These differences may be due to compensatory mechanisms in response to dopaminergic neuronal loss.
EXPERIMENTAL NEUROBIOLOGY
(2021)
Article
Neuroimaging
Noor Adra, Aihua Cao, Nikos Makris, Eve M. Valera
Summary: Individuals with ADHD show more symptoms of sensory processing disorder compared to healthy controls, with sensory craving and sensory under-responsivity being positively associated with amygdalar volume, sensory under-responsivity also positively associated with striatal volume, and sensory over-responsivity negatively associated with posterior ventral diencephalon volume. These findings suggest that sensory processing modulations in ADHD may involve unique neural circuits, influenced by co-occurring anxiety. Conducting larger studies in adults with ADHD is necessary to further explore the implications of these findings.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Demetrio Milardi, Gianpaolo Antonio Basile, Joshua Faskowitz, Salvatore Bertino, Angelo Quartarone, Giuseppe Pio Anastasi, Alessia Bramanti, Rosella Ciurleo, Alberto Cacciola
Summary: This study aimed to test the effects of different tractography-based approaches for the reconstruction of subthalamic nucleus (STN) functional territories. Four parcellation pipelines were compared, and it was found that each parcellation provided consistent results in terms of location of the identified parcels, but with variations in size and shape. It is suggested that fine-tuning of tractography-based parcellation may lead to higher reproducibility and aid the development of an optimized surgical targeting protocol.
Article
Neuroimaging
Stephanie Lescher, Maja Zimmermann, Juergen Konczalla, Thomas Deller, Luciana Porto, Volker Seifert, Joachim Berkefeld
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2016)
Article
Clinical Neurology
Marlies Wagner, Michael Helfrich, Steffen Volz, Joerg Magerkurth, Stella Blasel, Luciana Porto, Oliver C. Singer, Ralf Deichmann, Alina Jurcoane, Elke Hattingen
Article
Clinical Neurology
Natalia Luesebrink, Luciana Porto, Hans R. Waterham, Sacha Ferdinandusse, Hendrik Rosewich, Gerd Kurlemann, Matthias Kieslich
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2016)
Article
Clinical Neurology
Stephanie Lescher, Valerie Wickmann, Peter Hofstetter, Luciana Porto
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2016)
Article
Clinical Neurology
Stephanie Lescher, Ketan Whora, Dirk Schwabe, Matthias Kieslich, Luciana Porto
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2016)
Article
Neuroimaging
Stephanie Lescher, Christina Reh, Maya Christina Hoelter, Katja Czeppan, Luciana Porto, Stella Blasel, Joachim Berkefeld, Marlies Wagner
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2016)
Article
Clinical Neurology
S. Tritt, N. Hillenbrand, K. Liesirova, G. Moein, M. Kieslich, L. Porto
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2018)
Article
Clinical Neurology
Constanze Buus-Gehrig, Thomas Lehrnbecher, Luciana Porto, Martina Becker, Thomas Freiman, Michel Mittelbronn, Konrad Bochennek
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2019)
Article
Pediatrics
Owen J. Arthurs, Rick R. van Rijn, Claudio Granata, Luciana Porto, F. Wolfgang Hirsch, Karen Rosendahl
PEDIATRIC RADIOLOGY
(2019)
Article
Microbiology
Luciana Porto, Se-Jong You, Andishe Attarbaschi, Gunnar Cario, Michaela Doering, Olga Moser, Urs Muecke, Fiona Poyer, Christian Temme, Sebastian Voigt, Andreas H. Groll, Melchior Lauten, Elke Hattingen, Thomas Lehrnbecher
Review
Microbiology
Marie Luckowitsch, Henriette Rudolph, Konrad Bochennek, Luciana Porto, Thomas Lehrnbecher
Summary: The incidence of invasive mold disease (IMD) has been increasing, especially in the form of CNS IMD, which is particularly severe, but there is a lack of data on the incidence of CNS IMD in pediatric patients. Further research is needed on the diagnosis and treatment of CNS IMD, with a particular focus on the safety and efficacy in pediatric patients.
Review
Pediatrics
Katharina J. Wenger, Elke Hattingen, Luciana Porto
Summary: Inflammatory nontraumatic atlantoaxial rotatory subluxation (AAS) in children is often overlooked and requires early diagnosis and evaluation with MRI, especially in children with a history of meningitis or otolaryngological surgery.
Article
Pediatrics
Katharina J. Wenger, Caroline E. Koldijk, Elke Hattingen, Luciana Porto, Wiebke Kurre
Summary: This study retrospectively characterized WMSAs in an unselected patient cohort at a large pediatric neuroimaging facility, aiming to learn more about the underlying disorders encountered in everyday clinical practice. The majority of WMSAs were acquired and were non-specific in brain MRI, followed by autoimmune disorders and non-genetic hypoxic and ischemic insults.
Article
Oncology
Luciana Porto, Stefan Schoening, Elke Hattingen, Jan Soerensen, Alina Jurcoane, Thomas Lehrnbecher
RADIOLOGY AND ONCOLOGY
(2015)
Article
Infectious Diseases
Angela Hassler, Luciana Porto, Thomas Lehrnbecher
CURRENT FUNGAL INFECTION REPORTS
(2015)
