Article
Biochemistry & Molecular Biology
Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Vincenzo Vindigni, Roberto Vettor, Marco Rossato
Summary: In this study, the effects of sex steroids on the expression of inflammatory mediators in human-derived adipocytes were evaluated. The results showed that non-aromatizable androgen DHT and the aromatase inhibitor anastrozole in combination with testosterone significantly enhanced the expression of inflammatory cytokines induced by LPS. These results confirm the involvement of sex hormones in adipose tissue inflammation and suggest a specific role for non-aromatizable androgens as amplificatory sex hormones of the inflammatory response.
Review
Endocrinology & Metabolism
G. Molina-Salinas, N. A. Rivero-Segura, E. A. Cabrera-Reyes, V Rodriguez-Chavez, E. Langley, M. Cerbon
Summary: Prolactin plays a crucial role in neuroprotection against excitotoxicity, although the underlying signaling pathways, such as PI3K/AKT, NF-kappa B, and JAK2/STAT5, remain unclear and require further investigation. Its remarkable neuroprotective effects may hold promise for the treatment of certain neurological diseases.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manuel Alcarranza, Isabel Villegas, Rocio Recio, Rocio Munoz-Garcia, Inmaculada Fernandez, Catalina Alarcon-de-la-Lastra
Summary: The aim of this study was to develop a synthetic route to obtain natural (R)-8-OITC from watercress and evaluate its antioxidant and immunomodulatory effects in an ex vivo model. Treatment with (R)-8-OITC inhibited pro-inflammatory cytokines, ROS production, and expression of pro-inflammatory enzymes through modulation of Nrf2, MAPKs, JAK/STAT, and inflammasome pathways. These results suggest that (R)-8-OITC could be a potential nutraceutical candidate for immuno-inflammatory pathologies, requiring further in vivo trials.
Article
Biology
Mustafa Guzel, Orhan Akpinar
Summary: The study investigated the effects of HCQ and TRPV1 inhibitor on U937 monocytes exposed to LPS-induced acute inflammation, showing a reduction in oxidative stress and cell death. Treatment with HCQ and CPZ led to anti-inflammatory, anti-apoptotic, and antioxidant effects by inhibiting cROS, cytokine generation, and caspase activation. The data suggest that TRPV1 activation contributes to inflammatory, oxidative, and apoptotic actions in monocytes induced by acute INF, while HCQ prevents these adverse effects by modulating TRPV1.
Review
Cell Biology
Yuqing Zhang, De Jin, Xiaomin Kang, Rongrong Zhou, Yuting Sun, Fengmei Lian, Xiaolin Tong
Summary: The review discusses the pathological mechanisms of diabetic renal fibrosis and related signaling pathways to provide novel therapeutic intervention insights for clinical research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Jing Xu, Xinxin Zhang, Mingming Zhou, Peizhe Lu, Yuting Xu, Lihong Wu, Qianyue Zhang, Zhihua Wu, Xiaoyu Xu, Pengfei Shi, Qingda Wei, Xiaoyu Li, Qiaoling Song
Summary: In this study, a new bioactive compound C498-0670 was identified as a dual inhibitor of JAK/STAT and NF kappa B signaling pathways. C498-0670 exhibited anti-inflammatory effects by inhibiting the activation of STATs and p-IKK alpha/beta, suppressing the expression of inflammatory mediators, and reducing tissue damage and pro-inflammatory cytokine production in vivo. Target fishing and molecular docking approaches confirmed the high affinities of C498-0670 for JAK2, NFKBIA, IL-1 beta, and NLRP1b. These findings suggest C498-0670 as a potential therapeutic option for various inflammatory diseases, particularly septic shock.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jadwiga N. Bilchak, Guillaume Caron, Marie-Pascale Cote
Summary: Exercise is the superior therapy for most SCI sequalae, influencing peripheral health and CNS disorders by activating relevant neural pathways. Recent research has focused on understanding the molecular underpinnings of exercise-induced effects, particularly the increase in neurotrophins, to enhance intervention strategies and improve quality of life for SCI-affected individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Lianxiang Luo, Fangfang Huang, Saiyi Zhong, Rui Ding, Jiating Su, Xiaoling Li
Summary: In this study, it was found that astaxanthin can inhibit inflammation and ferroptosis by regulating the Keap1-Nrf2/HO-1 pathway, thereby reducing the occurrence and development of LPS-induced ALI.
Article
Genetics & Heredity
Mojtaba Najafi, Yongzhi Guo, Goran Andersson, Patrice Humblot, Erik Bongcam-Rudloff
Summary: LPS, a component of Gram-negative bacteria outer membrane, is involved in the pathogenic processes of mastitis and metritis in dairy cattle. In vitro studies have shown that LPS stimulates the proliferation of bovine endometrial epithelial cells. Transcriptomic analysis of these cells treated with LPS revealed differentially expressed genes associated with proliferation and apoptosis. The analysis also identified putative transcription factors and their interactions, providing insights into the mechanisms underlying the proliferative and apoptosis processes. Additionally, the study shed light on the early signaling and metabolic pathways involved in the immune response and cell proliferation in bovine endometrial epithelial cells infected with Escherichia coli-LPS.
Article
Immunology
Xianbo Liu, He Yang, Zhenning Liu
Summary: Paraquat poisoning is a severe global health issue, particularly in developing countries, with a mortality rate higher than other pesticide poisoning. The potential mechanisms of toxicity are extremely complicated, causing damage in various organs such as lung, liver, and kidney.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Ning Ding, Pibao Li, Huiqing Li, Yunlong Lei, Zengzhen Zhang
Summary: The RhoA/ROCK-ezrin/Syk-MyD88/IRAK1 axis plays an important role in the LPS-induced production of pro-inflammatory cytokines in pulmonary alveolar epithelial cells.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Endocrinology & Metabolism
Maria Magdalena Montt-Guevara, Michele Finiguerra, Ilaria Marzi, Tiziana Fidecicchi, Amerigo Ferrari, Alessandro D. Genazzani, Tommaso Simoncini
Summary: D-Chiro-Ins directly affects the differentiation and function of human adipocytes, synergizing with insulin and estrogen to promote lipid and glucose storage. This research provides insights into D-Chiro-Ins actions on fat metabolism and their implications in various diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Dong Zhao, Li Jun Zhang, Tian Qi Huang, Joonki Kim, Ming-Yao Gu, Hyun Ok Yang
Summary: Narciclasine (NA) inhibits pro-inflammatory factors in LPS-induced microglial cells but increases anti-inflammatory cytokines. The study suggests that NA may relieve neuroinflammation by down-regulating the Akt/IKK/NF-kappa B and JNK signaling pathways.
Review
Environmental Sciences
Muhammad Tanveer, Nimra Mansha, Afzal Nimra, Muhammad Babar Khawar, Ali Afzal, Hanan Afzal, Muhammad Farooq, Sadia Ehsan, Rabbia Rana, Sara Shahzaman
Summary: Microplastics (MPs) are biologically active environmental pollutants that significantly impact the ecosystem and human health. These particles increase oxidative stress, leading to tissue damage, developmental abnormalities, metabolic disorders, epigenetic changes, abnormal reproduction, and reduced gamete quality. While there have been numerous studies on the effects of MPs on aquatic organisms, particularly their reproduction, the specific impact on mammalian reproduction, especially humans, remains limited. This review examines the effects of MPs on male and female reproduction, focusing on compromised gamete quality, gamete toxicity, apoptosis, and DNA damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jin-Chuan Liu, Peng Wang, Qun-Xiong Zeng, Chen Yang, Minmin Lyu, Yanfeng Li, William Shu-Biu Yeung, Philip Chi-Ngong Chiu, Gerhard Haidl, Jean-Pierre Allam, Yong-Gang Duan
Summary: This study investigated the role of Myd88 in DCs for epididymitis. The results showed that in mice with epididymitis, the levels of proinflammatory cytokines, mRNA for MyD88 related genes, and the percentages of monocyte-derived DCs were significantly elevated. Additionally, LPS significantly promoted the apoptosis of BMDCs, while knockout of Myd88 decreased the concentration of inflammatory cytokines in BMDCs and DC2s. These findings suggest that Myd88 on DCs is involved in the inflammation of epididymitis in mice and may be a potential target for the treatment of immunological male infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Ahmad Abdullah, Palaniyandi Ravanan
EUROPEAN JOURNAL OF CELL BIOLOGY
(2018)
Article
Cell Biology
Krishna Sundar Twayana, Namrata Chaudhari, Palaniyandi Ravanan
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Angelique Arcambal, Janice Taile, Philippe Rondeau, Wildriss Viranaicken, Olivier Meilhac, Marie-Paule Gonthier
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Anthony Dobi, Susana B. Bravo, Bryan Veeren, Beatriz Paradela-Dobarro, Ezequiel Alvarez, Olivier Meilhac, Wildriss Viranaicken, Pascal Baret, Anne Devin, Philippe Rondeau
FREE RADICAL RESEARCH
(2019)
Article
Endocrinology & Metabolism
Heidrun Vethe, Luiza Ghila, Magnus Berle, Laurence Hoareau, Hystein A. Haaland, Hanne Scholz, Joao A. Paulo, Simona Chera, Helge Raeder
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Cell & Tissue Engineering
Yngvild Bjorlykke, Anne M. Soviknes, Laurence Hoareau, Heidrun Vethe, Andreas F. Mathisen, Simona Chera, Marc Vaudel, Luiza M. Ghila, Helge Raeder
STEM CELLS INTERNATIONAL
(2019)
Article
Physiology
Laurence Hoareau, Agnete S. T. Engelsen, Marianne Aanerud, Maria Paula Ramnefjell, Pirjo-Riitta Salminen, Fabian Gartner, Thomas Halvorsen, Helge Raeder, Mariann H. L. Bentsen
Summary: This study presents a new approach to derive alveolar and bronchiolar organoids from human lung biopsies. By modulating the Wnt pathway, differential gene expression in alveolar and bronchiolar organoids was achieved, along with early signs of differentiation observed from the first passages.
PHYSIOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jonathan Bonneville, Philippe Rondeau, Bryan Veeren, Julien Faccini, Marie-Paule Gonthier, Olivier Meilhac, Cecile Vindis
Summary: This study evaluated the antioxidant and cytoprotective effects of polyphenol-rich extracts from two medicinal plants, A. borbonica and D. apetalum, from Reunion Island. The results showed that the polyphenol extracts of these plants could limit LDL oxidation and intracellular oxidative stress, and protect the endothelium.
Article
Immunology
Camilla Tvedt Ekanger, Fan Zhou, Dana Bohan, Maria Lie Lotsberg, Maria Ramnefjell, Laurence Hoareau, Gro Vatne Rosland, Ning Lu, Marianne Aanerud, Fabian Gaertner, Pirjo Riitta Salminen, Mariann Bentsen, Thomas Halvorsen, Helge Raeder, Lars A. Akslen, Nina Langeland, Rebecca Cox, Wendy Maury, Linda Elin Birkhaug Stuhr, James B. Lorens, Agnete S. T. Engelsen
Summary: The ongoing COVID-19 pandemic has led to unprecedented research efforts in understanding the pathogenesis of SARS-CoV-2. This study successfully established a human organoid model representing the respiratory tract, which is useful for studying respiratory virus infections and evaluating regional differences in host response. The model supports successful infection and replication of influenza virus and SARS-CoV-2, making it a relevant and reliable tool in virology research.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Janice Taile, Matthieu Bringart, Cynthia Planesse, Jessica Patche, Philippe Rondeau, Bryan Veeren, Patricia Clerc, Anne Gauvin-Bialecki, Steeve Bourane, Olivier Meilhac, David Couret, Marie-Paule Gonthier
Summary: This study evaluated the effects of polyphenols extracted from Antirhea borbonica on obesity and diabetes-related cerebrovascular damages during stroke. The results showed that polyphenols reduced insulin resistance, hyperglycemia, and dyslipidemia caused by obesity, and attenuated brain infarct, hemorrhagic transformation, and blood-brain barrier disruption. Polyphenols also exhibited anti-inflammatory and antioxidant properties, and decreased MMP-2 activity in hyperglycemic condition. Furthermore, the protective effects of polyphenols were associated with their circulating metabolites.
Article
Chemistry, Medicinal
Sai Sandhya Narra, Sarah Rosanaly, Philippe Rondeau, Jessica Patche, Bryan Veeren, Marie-Paule Gonthier, Wildriss Viranaicken, Nicolas Diotel, Palaniyandi Ravanan, Christian Lefebvre d' Hellencourt, Olivier Meilhac
Summary: This study aimed to improve the bioavailability of curcumin and evaluate the synergistic effect of curcumin-reconstituted high-density lipoprotein nanoparticles on MGO-induced endothelial dysfunction in diabetic patients. The results showed that Cur-rHDL nanoparticles can alleviate MGO-induced cytotoxicity and oxidative stress, protect endothelial cell barrier integrity, and enhance the bioavailability of curcumin.
Article
Biochemistry & Molecular Biology
Chloe Turpin, Olivier Meilhac, Emmanuel Bourdon, Francois Canonne-Hergaux, Philippe Rondeau
Summary: Red blood cells play a crucial role in circulation and their aging process, as well as the phagocytosis by professional and non-professional phagocytes, can contribute to disease progression. Investigating the mechanisms of erythrophagocytosis is vital for understanding pathologies.
Article
Cell Biology
Chloe Turpin, Marie Laurine Apalama, Bastian Carnero, Alberto Otero-Cacho, Alberto P. Munuzuri, Maria Teresa Flores-Arias, Erick Velia, Olivier Meilhac, Emmanuel Bourdon, Ezequiel Alvarez, Philippe Rondeau
Summary: This study investigates the impact of glycation on the structure and ability of erythrocytes to alter endothelial cell function. Results show that glycation enhances oxidative stress and erythrophagocytosis by endothelial cells, leading to impaired endothelial cell function. These findings have important implications for understanding the mechanism of diabetic vascular complications.
Article
Biochemistry & Molecular Biology
Priti Talwar, Pratibha Singh, Palaniyandi Ravanan
Summary: Recently, a new signaling complex involving DAPK1 and NR2B was discovered to play a role in neuronal death cascade, where NMDA receptors interact with DAPK1 through NR2B subunit after stroke injury, leading to excitotoxicity. Using the ZINC-12 database, potential inhibitors of DAPK1 were identified, particularly natural compounds showing strong binding affinity with both ATP-binding site residues and substrate-recognition motifs. These findings suggest that these ligands have the potential to be inhibitors of DAPK1.
MOLECULAR BIOTECHNOLOGY
(2023)