Article
Nutrition & Dietetics
Alexandra Adorno Vita, Heather Zwickey, Ryan Bradley
Summary: The study found significant associations between food-specific IgG antibodies and intestinal permeability biomarkers in adults, particularly antibodies against LPS and occludin. While levels of IgG antibodies and permeability biomarkers did not increase in symptomatic patients, the presence of multiple IgG antibodies and increasing titers can be indicative of higher levels of antibodies.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Riccardo Vasapolli, Christian Schulz, Melanie Schweden, Christina Casen, Graceline Tina Kirubakaran, Katrine Hanes Kirste, Lukas Macke, Alexander Link, Kerstin Schuette, Peter Malfertheiner
Summary: This study found that the positivity rate of anti-CdtB and anti-vinculin antibodies was higher in patients with constipation-type IBS, who also exhibited more dysbiosis with increased opportunistic/pro-inflammatory bacteria and reduced gut protective bacteria. Microbial profiles of patients with diarrhoea-type IBS and functional dyspepsia were similar to those of healthy controls.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Jia-Yin Yeh, Hwai-Jeng Lin, Chia-Jung Kuo, Chun-Lung Feng, Chia-Huei Chou, Chia-Der Lin, Hui-Yu Wu, Chen-Yi Li, Cheng-Hsun Chiu, Chih-Ho Lai
Summary: Using recombinant CdtC can alleviate the effects of H. pylori cytotoxins in cells, mitigating H. pylori-induced gastric epithelial cell inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miao Qian, Shuyang Cao, Tao Wang, Xiangming Xu, Quan Zhang
Summary: In this study, it was found that bacterial toxin CdtB promotes the expression of inflammatory cytokines, decreases cell viability, and induces cell apoptosis. Moreover, CdtB triggers apoptosis through the MAPK/Erk/p38 signaling pathway and is inhibited by autophagy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Microbiology
Wencan He, Lamia Azzi-Martin, Valerie Velasco, Philippe Lehours, Pierre Dubus, Mojgan Djavaheri-Mergny, Armelle Menard
Summary: This study revealed the activation of autophagy following genotoxic stress induced by bacterial toxins, suggesting its role in removing genotoxin-induced micronuclei-like structures and protecting cells against apoptotic cell death. Additionally, the study found that autophagy and P62/SQSTM1 play a regulatory role in cell survival following DNA damage induced by bacterial genotoxins.
Review
Immunology
T. W. Hand, A. E. Overacre-Delgoffe
Summary: The gut microbiota, particularly certain adherent bacterial species within the Helicobacteraceae family, has been found to play a unique role in immunotherapeutic resistance or response in cancer patients, with their functional characteristics determining the type of immune response and overall cancer progression.
TRENDS IN IMMUNOLOGY
(2022)
Article
Immunology
Liqi Zhu, Chen Zhu, Shuyang Cao, Quan Zhang
Summary: The mechanisms underlying the progression of colitis induced by H. hepaticus remain unclear, but the study revealed that CdtB promotes colitis development in male B6.129P2-IL10(tm1Cgn)/J mice by inducing inflammatory response and activating the Jak-Stat signaling pathway.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Shinichiro Horii, Hirofumi Sugawara, Hitoshi Goto, Munetaka Hashimoto, Tetsuro Matsunaga, Daijirou Akamatsu, Yuta Tajima, Michihisa Umetsu, Takaaki Akaike, Takashi Kamei
Summary: The presence of H. cinaedi was detected in the walls of clinically non-infectious abdominal aortic aneurysms (AAA) for the first time.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Microbiology
Claudia Sousa, Rute Ferreira, Nuno F. Azevedo, Monica Oleastro, Joana Azeredo, Ceu Figueiredo, Luis D. R. Melo
Summary: H. pylori infection treatment faces challenges due to antibiotic resistance, leading to the development of alternative strategies like probiotics, antimicrobial peptides, and photodynamic therapy. Human vaccine development remains a major challenge, while natural products show potential against H. pylori, requiring further clinical studies.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Patricia Laquel, Eric Testet, Karine Tuphile, Christophe Cullin, Laetitia Fouillen, Jean-Jacques Bessoule, Francois Doignon
Summary: Cell polarity is achieved through regulators and phosphoinositides, and phosphoinositides play a key role in directing protein and lipid transportation to the cell surface for asymmetric growth. By genetically manipulating the PSI1 gene, which encodes a lysophosphatidylinositol acyl transferase, the importance of stearic acid in phosphoinositides for cytoskeletal organization and secretion has been demonstrated. Furthermore, it has been found that stearic acid-containing phosphoinositides can bypass the lack of phosphatidylinositol-4-phosphate (PI(4)P) and modify the late steps of the secretory pathway, affecting the interactions between key proteins and preventing the activation of the exocyst.
Review
Microbiology
Igor Venancio, Angelo Luis, Fernanda Domingues, Monica Oleastro, Luisa Pereira, Susana Ferreira
Summary: This study used a systematic review and meta-analysis-based method to investigate the prevalence of Arcobacteraceae species in aquatic environments worldwide. The results revealed a high prevalence and wide distribution of Arcobacteraceae in different water bodies, posing a risk to human health. The study emphasizes the importance of identifying and managing sources of contamination and implementing preventive actions to reduce the burden of Arcobacteraceae family members.
Review
Oncology
Lornella Seeneevassen, Pierre Dubus, Caroline Gronnier, Christine Varon
Summary: The Hippo signalling pathway is important and complex in physiology, and its dysregulation can lead to cancer. In gastric carcinogenesis, the Hippo pathway and its effectors, YAP and TAZ, play a vital role. This review discusses the dysregulation of the Hippo pathway in gastric cancer and the strategies used to target it.
Article
Oncology
Paul Girot, Nicolas Chapelle, Laetitia Aymeric, Anne Bessard, Alice Prigent, Yann Touchefeu, Christine Varon, Michel Neunlist, Emilie Duchalais, Tamara Matysiak-Budnik
Summary: Gastric cancer is a leading cause of cancer-related deaths globally. This study investigated the adhesion of gastric cancer cells to enteric neurons, and found that enteric neurons are a privileged site for gastric cancer cell adhesion, especially in diffuse-type gastric cancer. The adhesion was partially mediated by N-Cadherin, and blocking N-Cadherin significantly decreased the adhesion ability. These findings suggest a potential role of enteric neurons in the dissemination of gastric cancer cells.
Letter
Immunology
Herve Dutronc, Elias Sawaya, Nicolas Poursac, Arnaud Desclaux, Armelle Menard, Olivia Peuchant
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Environmental Sciences
Rita Batista, Margarida Saraiva, Teresa Lopes, Leonor Silveira, Anabela Coelho, Rosalia Furtado, Rita Castro, Cristina Belo Correia, David Rodrigues, Pedro Henriques, Sara Loio, Vanessa Soeiro, Paulo Martins da Costa, Monica Oleastro, Angela Pista
Summary: This study investigated the occurrence of three important foodborne pathogens in free-living birds and gull feces in Portugal. Pathogenic Escherichia coli, Salmonella spp., and Campylobacter spp. were detected in the samples. These findings suggest that free-living birds in Portugal may act as carriers of foodborne pathogens linked to human disease.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Microbiology
Rodrigo Martins, Cristiana Mateus, Fernanda Domingues, Roland Buecker, Monica Oleastro, Susana Ferreira
Summary: This study demonstrates that oxygen levels can modulate the potential pathogenicity of A. butzleri, but the response varies among different strains.
Article
Infectious Diseases
Ines Martins, Cristiana Mateus, Fernanda Domingues, Monica Oleastro, Susana Ferreira
Summary: This study evaluated the role of the ABC efflux system (YbhFSR) on the resistance and virulence of Aliarcobacter butzleri. It was found that YbhFSR may influence the resistance to certain antimicrobial agents and potentially extrude toxic compounds from A. butzleri. However, no significant impact on the virulence properties of A. butzleri was observed. Further research is needed to understand the role of this efflux pump in the pathogenic mechanism of the bacterium.
Article
Public, Environmental & Occupational Health
Frederico Alves, Rita Castro, Miguel Pinto, Alexandra Nunes, Constanca Pomba, Manuela Oliveira, Leonor Silveira, Joao Paulo Gomes, Monica Oleastro
Summary: This study investigated the C. difficile strains in canine and feline populations and assessed their genetic overlap with human strains. The results showed that companion animals may be a source of infection for toxigenic and antimicrobial resistant C. difficile isolates associated with humans. This study provides important data on the genetic proximity between C. difficile isolates from animals and humans, contributing to future research on the role of animal reservoirs in the transmission networks and alerting to potential public health risks.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Gastroenterology & Hepatology
Raquel Antunes, Monica Oleastro, Joao Paulo Nogueira, Ana Isabel Lopes
Summary: This study found a relatively high prevalence of Helicobacter pylori infection in children in Portugal, but also observed a decreasing trend in infection rate. The study also identified certain endoscopic and histological features associated with H. pylori infection, as well as high rates of resistance to clarithromycin and metronidazole.
Correction
Multidisciplinary Sciences
Harry A. Thorpe, Elise Tourrette, Koji Yahara, Filipa F. Vale, Siqi Liu, Monica Oleastro, Teresa Alarcon, Tsachi-Tsadok Perets, Saeid Latifi-Navid, Yoshio Yamaoka, Beatriz Martinez-Gonzalez, Ioannis Karayiannis, Timokratis Karamitros, Dionyssios N. Sgouras, Wael Elamin, Ben Pascoe, Samuel K. Sheppard, Jukka Ronkainen, Pertti Aro, Lars Engstrand, Lars Agreus, Sebastian Suerbaum, Kaisa Thorell, Daniel Falush
NATURE COMMUNICATIONS
(2023)
Editorial Material
Microbiology
Monica Oleastro, Ana Botelho
Article
Microbiology
Alexandra Nunes, Monica Oleastro, Frederico Alves, Nadia Liassine, David M. Lowe, Lucie Benejat, Astrid Ducounau, Quentin Jehanne, Vitor Borges, Joao Paulo Gomes, Gauri Godbole, Lehours Philippe
Summary: Carbapenem susceptibility patterns in Campylobacter spp. are related to insertion and/or single nucleotide polymorphism (SNP) within porA gene, indicating drug impermeability. Two independent cases of recurrent multidrug-resistant Campylobacter jejuni infection in immunocompromised hosts were studied, and the mechanisms associated with carbapenem resistance were characterized.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Cristiana Mateus, Claudio J. Maia, Fernanda Domingues, Roland Buecker, Monica Oleastro, Susana Ferreira
Summary: Aliarcobacter butzleri can survive in physiological concentrations of bile salts and exposure to bile salts can change its virulence mechanisms.