期刊
JOURNAL OF INFECTIOUS DISEASES
卷 210, 期 8, 页码 1325-1338出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu260
关键词
Streptococcus pyogenes; vaccine; M protein; fibrinogen; plasminogen; IgA; IgG; molecular typing; epidemiology
资金
- European Society for Clinical Microbiology and Infectious Diseases
- European Society for Paediatric Infectious Diseases
- Fonds National de la Recherche Scientifique (Belgium)
- Fonds Brachet and Fondation Van Buuren (Belgium)
- Australian National Health and Medical Research Council (Australia)
- National Institutes of Health (USA)
- Victorian Government Operational Infrastructure Support Scheme
- Murdoch Childrens Research Institute
Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.
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