Article
Immunology
Gokul Raj Kathamuthu, Nathella Pavan Kumar, Kadar Moideen, Pradeep A. Menon, Subash Babu
Summary: In latent tuberculosis, individuals with diabetes mellitus or pre-diabetes, as well as non-diabetes comorbidities, show significantly reduced expression of cytokines, cytotoxic factors, and immune markers in gamma-delta T cells upon stimulation with specific antigens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Arpana Verma, Maninder Kaur, Princy Luthra, Lakshyaveer Singh, Divya Aggarwal, Indu Verma, Bishan D. D. Radotra, Sanjay Kumar Bhadada, Sadhna Sharma
Summary: Diabetes is a significant risk factor for latent tuberculosis activation and worsens tuberculosis treatment outcomes. The study focuses on understanding the interaction between M. tuberculosis and its host during latent tuberculosis infection under hyperglycemic conditions or diabetes. An animal model was used to study the relationship, and various host factors such as cytokines and MMPs were analyzed. The results showed that diabetes worsens the containment of mycobacterial infection and affects granuloma formation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Vivekanandhan Aravindhan, Anup Bobhate, Kuppan Sathishkumar, Aruna Patil, Satyavani Kumpatla, Vijay Viswanathan
Summary: This study investigated the prevalence of latent tuberculosis infection (LTBI) among diabetes patients and the relationship with immunoendocrine biomarkers.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Roma Sinha, Minh Dao Ngo, Stacey Bartlett, Helle Bielefeldt-Ohmann, Sahar Keshvari, Sumaira Z. Hasnain, Meg L. Donovan, Jessica C. Kling, Antje Blumenthal, Chen Chen, Kirsty R. Short, Katharina Ronacher
Summary: This study found that pre-diabetes increases susceptibility to TB, while a high body mass index without dysglycemia is protective. The murine model established in this study provides an opportunity to further study the underlying immunological, metabolic, and endocrine mechanisms of this association.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Phillip Ssekamatte, Marjorie Nakibuule, Rose Nabatanzi, Moses Egesa, Carol Musubika, Mudarshiru Bbuye, Matthew R. Hepworth, Derek G. Doherty, Stephen Cose, Irene Andia Biraro
Summary: The study showed that patients with LTBI and T2DM, as well as T2DM patients, had slight alterations in ILC immune responses, and poor T2DM control also slightly changed these immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mariana Herrera, Yoav Keynan, Lucelly Lopez, Diana Marin, Lazaro Velez, Paul J. McLaren, Zulma Vanessa Rueda
Summary: We studied the immune changes in newly acquired tuberculosis infection in a population deprived of liberty in Colombian prisons. We found differences in immune levels between individuals with new tuberculosis infection and those incarcerated for short and long periods of time. Certain cytokines/chemokines were associated with new tuberculosis infection and tuberculosis disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Erick J. Rendon Ramirez, Adrian G. Rosas-Taraco, Berenice Soto-Moncivais, Perla R. Colunga-Pedraza, Rosario Salazar-Riojas, Nereida Mendez-Ramirez, Alma Yolanda Arce-Mendoza, Antonio Muniz-Buenrostro, Jorge Llaca-Diaz, David Gomez-Almaguer, Adrian Rendon
Summary: This study found that CD4+ immunity remains altered in patients with pulmonary tuberculosis and diabetes even after antituberculosis treatment, while CD8+ immunity is relatively higher in patients with diabetes. Antituberculosis treatment does not have a significant impact on antibody levels.
Article
Biochemistry & Molecular Biology
Ednelza da Silva Graca Amoras, Thais Gouvea de Morais, Rafaella do Nascimento Ferreira, Samara Tatielle Monteiro Gomes, Francisca Dayse Martins de Sousa, Iury de Paula Souza, Ricardo Ishak, Antonio Carlos Rosario Vallinoto, Maria Alice Freitas Queiroz
Summary: This study investigated the association between genetic variations in cytokine genes, plasma cytokine levels, and the development of tuberculosis (TB) and latent tuberculosis infection (LTBI). The findings suggest that certain genetic variations in cytokine genes are associated with an increased risk of TB, and TB patients have distinct cytokine profiles compared to other groups.
Article
Microbiology
Mikhail V. Fursov, Egor A. Shitikov, Denis A. Lagutkin, Anastasiia D. Fursova, Elena A. Ganina, Tatiana I. Kombarova, Natalia S. Grishenko, Tatiana I. Rudnitskaya, Dmitry A. Bespiatykh, Nadezhda V. Kolupaeva, Viktoria V. Firstova, Lubov V. Domotenko, Anna E. Panova, Anatoliy S. Vinokurov, Vladimir A. Gushchin, Artem P. Tkachuk, Irina A. Vasilyeva, Vasiliy D. Potapov, Ivan A. Dyatlov
Summary: The study assessed the virulence of two clinical M. tuberculosis strains on C57BL/6 mice and found that the drug-resistant strain 267/47 caused more harm to the mice compared to strain H37Rv. The cytokine response in the lungs of infected mice also differed between the strains.
Article
Immunology
Nathella Pavan Kumar, Syed Hissar, Kannan Thiruvengadam, Velayuthum V. Banurekha, N. Suresh, Janani Shankar, S. Elilarasi, N. S. Gomathi, S. Kalpana, J. Ganesh, M. A. Aravind, Dhanaraj Baskaran, Srikanth Tripathy, Soumya Swaminathan, Subash Babu
Summary: The study identified IFN-γ, TNF-α, IL-2, and IL-17A as potential biomarkers for pediatric tuberculosis. Following anti-tuberculosis treatment, cytokine levels decreased significantly, and combiROC models showed high sensitivity and specificity, providing an accurate diagnostic method.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mikhail M. Kostik, Maria A. Makhova, Alexei S. Maletin, Shamai M. Magomedova, Lybov S. Sorokina, Masayuki Tsukasaki, Kazuo Okamoto, Hiroshi Takayanagi, Dmitriy S. Vasiliev, Darya Kozlova, Alexander Yu Mushkin
Summary: The study revealed significantly elevated levels of pro-inflammatory cytokines in pediatric chronic non-bacterial osteomyelitis (CNO) patients. Certain cytokines can distinguish between CNO patients and other diseases or healthy controls.
Article
Microbiology
Maria Alice Freitas Queiroz, Sandra Souza Lima, Ednelza da Silva Graca Amoras, Francisca Dayse Martins de Sousa, Iury de Paula Souza, Juliana Abreu Lima Nunes, Igor Brasil-Costa, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosario Vallinoto
Summary: Several factors, including epidemiological variables and cytokine levels, are associated with the development of different clinical forms of tuberculosis (TB). This study evaluated these factors in TB patients and controls. It found that older age, marriage, lower education level, and lower family income were associated with TB. Elevated levels of IFN-gamma and IL-4 were more likely in TB patients, and lower IFN-gamma levels were associated with extrapulmonary TB. IFN-gamma levels were found to be useful in differentiating between pulmonary and extrapulmonary TB.
Review
Immunology
Magdalena Kowalewicz-Kulbat, Camille Locht
Summary: Bacillus Calmette-Guerin (BCG) is an attenuated Mycobacterium bovis derivative widely used as a live vaccine against tuberculosis. Over the past few decades, genetic modifications have been used to improve the efficacy of BCG. Recombinant BCG strains have been engineered to produce various immune-modulatory molecules, offering potential protection against tuberculosis and other diseases such as cancer. However, most studies have been limited to mouse models, and the prophylactic or therapeutic potential of recombinant BCG strains in other species, including humans, has yet to be demonstrated.
Article
Immunology
Qili Yao, Yan Xie, Dandan Xu, Zilu Qu, Jian Wu, Yuanyuan Zhou, Yuying Wei, Huan Xiong, Xiao-Lian Zhang
Summary: The study revealed that the M.tb protein EST12 activates pyroptosis in macrophages and plays a key role in M.tb-induced immunity, while mouse lncRNA lnc-EST12 negatively regulates anti-M.tb innate immunity through interaction with FUBP3.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Kristina Ritter, Jasmin Rousseau, Christoph Hoelscher
Summary: This review discusses the importance of cytokine IL-27 in tuberculosis (TB) for protective inflammatory immune responses and the pathological sequelae of chronic inflammation. The timely restricted blockade of IL-27 signalling may promote better control of Mycobacterium tuberculosis (Mtb) infection but also lead to chronic hyperinflammation and immunopathology. IL-27 administration may be a potential treatment option for the immunopathological consequences of chronic TB.
FRONTIERS IN IMMUNOLOGY
(2022)