Article
Virology
Le Chi Cao, Vanessa Martin, Le Thi Kieu Linh, Tran Thi Giang, Ngo Thi Minh Chau, Ton Nu Phuong Anh, Vu Xuan Nghia, Nguyen Trong The, Truong Nhat My, Bui Tien Sy, Nguyen Linh Toan, Le Huu Song, C. -Thomas Bock, Thirumalaisamy P. Velavan
Summary: The prevalence of hepatitis E virus (HEV) in the Vietnamese population is underestimated. A study was conducted to investigate the seroprevalence of HEV antibodies and the presence of HEV RNA in blood donors. The results showed a high prevalence of HEV antibodies, with a higher risk in older individuals. Although HEV viraemia was not found in blood donors from Northern Vietnam, further surveillance is needed in other regions.
Article
Immunology
Pierre Cappy, Quentin Lucas, Nakourogou Kankarafou, Camille Sureau, Syria Laperche
Summary: Following a study demonstrating the role of hepatitis C virus (HCV) in transmitting hepatitis D virus (HDV) in a liver-humanized mouse model, a large cohort of HCV-positive blood donors were screened for HDV markers. However, no evidence of HCV-assisted propagation of HDV in humans was found.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Xuelian Deng, Dan Liu, Maelenn Pailine Delcourt, Huihui Gao, Lu Zhou, Daniel Candotti
Summary: Between 2011 and 2021, a total of 869,633 blood donations were collected from prequalified donors in Dalian, China. Only 0.12% of the samples were confirmed to be positive for hepatitis B virus (HBV). Testing for hepatitis delta virus (HDV) antibodies in 2175 donations revealed that only 0.09% of the samples showed weak reactivity, but they were confirmed to be false positives upon repeat testing. Among the confirmed occult HBV infection (OBI) samples, only one non-Chinese donor showed repeated reactivity to HDV antibodies, suggesting that HDV/HBV coinfection does not play a significant role in the genesis of OBI. Overall, the data indicated a very low prevalence of HDV infection among blood donors in Liaoning province, Northeast China.
Article
Cardiac & Cardiovascular Systems
Ersilia M. DeFilippis, Kiran K. Khush, Maryjane A. Farr, Amy Fiedler, Arman Kilic, Michael M. Givertz
Summary: The burden of end-stage heart failure is increasing, but the number of available organs for heart transplantation remains inadequate. Recent advances in heart transplantation include the use of hearts from donors infected with hepatitis C virus and other underutilized donors, as well as advancements in surgical techniques and management strategies to increase the number of available organs and improve transplantation success rates.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Virology
Giulietta Venturi, Massimo Fabiani, Antonello Amendola, Giulia Marsili, Eleonora Benedetti, Cristiano Fiorentini, Claudia Fortuna, Simonetta Pupella, Patrizio Pezzotti, Stefania Vaglio, Giulio Pisani, Vincenzo De Angelis, Flavia Riccardo, Ilaria Pati
Summary: This study investigated the prevalence of recent/ongoing Chikungunya virus (CHIKV) infections in blood donors in the Lazio Region during the 2017 outbreak. Through testing 4595 plasma samples, it was found that there was no evidence of recent/ongoing CHIKV infections in blood donors of the affected area.
Article
Hematology
Maddalena Casale, Maria Grazia Di Girolamo, Nicoletta Di Maio, Rita Tomeo, Martina Iengo, Saverio Scianguetta, Teresa Palma, Federica Porcelli, Saverio Misso, Silverio Perrotta
Summary: This study demonstrates that deplasmated and leukodepleted red blood cells (RBCs) do not contain significant amounts of immune globulin, and transfusions with these RBCs do not require delayed vaccinations. The removal of IgG content from the RBC units ensures the absence of anti-COVID-19 antibodies, even from donors with high serum titre.
ANNALS OF HEMATOLOGY
(2023)
Article
Virology
Tatiana Kuznetsova, Diana Moor, Gulara Khanirzayeva, Julia Geller
Summary: Hepatitis E virus (HEV) is the most common cause of acute hepatitis worldwide. This study analyzed 1002 sera samples from blood donors in Estonia to determine the prevalence of anti-HEV antibodies and RNA. The study found that 4.8% of the donor sera had anti-HEV antibodies, with 4% harboring anti-HEV IgG and 1.5% containing anti-HEV IgM. None of the listed risk factors were found to be associated with the presence of anti-HEV antibodies. The study also observed an increasing prevalence of anti-HEV IgG with age. HEV RNA was not detected in any of the blood serum samples. Based on these findings, there is no urgent necessity for total screening of blood plasma for HEV RNA prevalence in Estonia.
Article
Immunology
Maria Isabel Costafreda, Silvia Sauleda, Angie Rico, Maria Piron, Marta Bes
Summary: This study found that nonenveloped HEV particles can be detected in the plasma of HEV-infected blood donors, which may pose an additional risk to blood safety. The study also observed a higher proportion of nonenveloped HEV in samples with HEV-positive serology and/or increased levels of liver injury markers.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Manuel Uribe, Miguel E. Rodriguez-Posada, Gloria C. Ramirez-Nieto
Summary: This study aimed to determine the presence of AIV and new influenza-like subtypes in South American bats. The results showed that three bat species were reported for the first time as susceptible hosts of AIV among the seven positive bat species found. These findings expand the epidemiological knowledge and distribution of AIV in neotropical free-ranging bats.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Jin, Yi Zhou, Wenfeng Deng, Yuchen Wang, Richard J. Lee, Yanna Liu, Nahel Elias, Yangcheng Hu, Min-Hua Luo, Rumin Liu, Bowen Guan, Jian Geng, Jian Xu, Junfeng Ma, Jiapeng Zhou, Na Liu, Michael L. Blute, Robert B. Colvin, Chin-Lee Wu, Yun Miao
Summary: Chronic BK polyomavirus (BKPyV) infection is considered a potential oncogenic factor for urothelial carcinoma (UC) in renal transplant recipients. Integration sites between human and BKPyV genomes were enriched with microhomologies, and viral insertional integration led to fusion sequences of 75 human genes, with 15 genes showing statistical association with UC based on expression analysis. These findings suggest a potential mechanism of viral-driven carcinogenesis in BKPyV-related UC.
Article
Virology
Magdalena Baymakova, Krasimira Terzieva, Rumen Popov, Elisaveta Grancharova, Todor Kundurzhiev, Roman Pepovich, Ilia Tsachev
Summary: This study investigated the seroprevalence of HEV infection among blood donors in Bulgaria, revealing a high rate of HEV seropositivity in this population.
Article
Public, Environmental & Occupational Health
Maria Belen Pisano, Sebastian Blanco, Guadalupe Di Cola, Anabella C. Fantilli, Maribel Graciela Martinez Wassaf, Luis H. Carrizo, Viviana E. Re
Summary: This study identified for the first time the molecular presence of hepatitis E virus (HEV) in blood donors from Argentina, showing a molecular prevalence comparable to that observed in blood donors from other non-endemic countries. Additionally, some immunocompetent HEV-positive donors without serological evidence of infection were identified. The presence of viraemic donors raises concerns about the possibility of transfusion transmission.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Gastroenterology & Hepatology
Saifu Yin, Lijuan Wu, Fan Zhang, Xinyi Huang, Jiapei Wu, Xianding Wang, Tao Lin
Summary: This study reported kidney transplant outcomes from HBsAg(+) donors to HBsAg(-) recipients. It was found that there was a higher risk of de novo HBV infection in recipients receiving HBsAg(+) kidneys, but graft and patient survival rates were comparable. Additionally, the risk was also higher when receiving kidneys from HBV DNA(+) or HBeAg(+) donors. Therefore, these findings help expand the donor pool and highlight the importance of donor antiviral treatment and recipient HBV immunity in prophylactic regimens.
LIVER INTERNATIONAL
(2023)
Article
Virology
Ru Xu, Jieting Huang, Chaohui Duan, Qiao Liao, Zhengang Shan, Min Wang, Xia Rong, Chengyao Li, Yongshui Fu, Hao Wang
Summary: The study found a low prevalence of past SARS-CoV-2 infection among 2199 blood donors in Guangzhou, with only two samples testing positive for IgG and IgA. There was no detectable viral nucleic acid in any of the samples, indicating limited necessity for COVID-19 testing in low-risk areas.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Caixin Gong, Wei Guan, Xiangmei Liu, Yufeng Zheng, Zhaoyang Li, Yu Zhang, Shengli Zhu, Hui Jiang, Zhenduo Cui, Shuilin Wu
Summary: This study focuses on clearing multidrug-resistant bacteria through nonantibiotic treatments. The researchers combined a thermally responsive donor of nitric oxide with food-grade Lactobacillus casei extracts to create biomimetic microparticles. These microparticles can disrupt bacterial metabolisms and cell membranes, leading to the death of multidrug-resistant Staphylococcus aureus (MRSA). The researchers also found that these microparticles can weaken bacterial toxicity and promote cell proliferation. By encapsulating the microparticles into a polymer, a dual-mode antibacterial hydrogel was developed, which showed long-term sterilization and fast disinfection effects. Additionally, the hydrogel accelerated wound healing.
ADVANCED MATERIALS
(2022)