Pre-clinical Modeling of CCR5 Knockout in Human Hematopoietic Stem Cells by Zinc Finger Nucleases Using Humanized Mice

Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases

(2013) Lijing Li et al.   MOLECULAR THERAPY

Engineering HIV-1-Resistant T-Cells from Short-Hairpin RNA-Expressing Hematopoietic Stem/Progenitor Cells in Humanized BLT Mice

(2013) Gene-Errol E. Ringpis et al.   PLoS One

Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient

(2013) Steven A. Yukl et al.   PLoS Pathogens

Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice

(2012) E. M. Hur et al.   BLOOD

HIV-1 immunopathogenesis in humanized mouse models

(2012) Liguo Zhang et al.   Cellular & Molecular Immunology

Generation of an HIV-1-Resistant Immune System with CD34+ Hematopoietic Stem Cells Transduced with a Triple-Combination Anti-HIV Lentiviral Vector

(2012) J. E. Walker et al.   JOURNAL OF VIROLOGY

New generation humanized mice for virus research: Comparative aspects and future prospects

(2012) Ramesh Akkina   VIROLOGY

The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment

(2011) Bradford K Berges et al.   Retrovirology

Inhibition of In Vivo HIV Infection in Humanized Mice by Gene Therapy of Human Hematopoietic Stem Cells with a Lentiviral Vector Encoding a Broadly Neutralizing Anti-HIV Antibody

(2010) A. Joseph et al.   JOURNAL OF VIROLOGY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

Chemokine receptor 5 knockout strategies

(2010) Paula Cannon et al.   Current Opinion in HIV and AIDS

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

(2009) S. Shimizu et al.   BLOOD

Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice

(2009) Christin M. Lepus et al.   HUMAN IMMUNOLOGY

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

(2009) Ronald T Mitsuyasu et al.   NATURE MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis

(2009) Manuela Rossol et al.   ARTHRITIS RESEARCH & THERAPY

NOD/SCID repopulating cells contribute only to short-term repopulation in the baboon

(2008) P Mezquita et al.   GENE THERAPY

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY