期刊
JOURNAL OF INFECTIOUS DISEASES
卷 209, 期 6, 页码 940-949出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit612
关键词
GALT; HIV; IFN alpha; immune activation; pDC
资金
- Abbvie
- Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung, BMBF) [01KI1017]
Aberrant activation of plasmacytoid dendritic cells (pDCs) with excessive production of interferon alpha (IFN alpha) represents one of the hallmarks of immune activation during chronic phase of human immunodeficiency virus (HIV) infection. A number of studies have shown that disruption of mucosal integrity in the gut is a cause of persistent immune activation. However, little is known about the role that pDCs play in this process, and our current understanding comes from the simian immunodeficiency virus macaque model. Thus, in the present study we sought to investigate the frequency and function of pDCs in peripheral blood and gut samples from HIV-infected individuals before and 6 months after initiation of antiretroviral therapy (ART). We show that circulating pDCs were depleted in ART-naive HIV+ patients, and upregulated the gut-homing receptor CD103 compared with uninfected controls. By converse, pDCs accumulated in the terminal ileum of ART-naive HIV individuals compared with controls. Baseline levels of IFNa production and markers of immune activation in gut samples of ART-naive HIV subjects were elevated. All these parameters declined after 6 months of ART. Our results suggest that in chronic HIV infection, pDCs migrate from peripheral blood to the gut-associated lymphatic tissue, where they may contribute to immune activation.
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