Article
Cell Biology
Mallory Paynich Murray, Catherine M. Crosby, Paola Marcovecchio, Nadine Hartmann, Shilpi Chandra, Meng Zhao, Archana Khurana, Sonja P. Zahner, Bjorn E. Clausen, Fadie T. Coleman, Joseph P. Mizgerd, Zbigniew Mikulski, Mitchell Kronenberg
Summary: This study investigates the roles of innate-like T cells during pulmonary pneumococcal infection. The researchers found that these T cells rapidly increase in the lung tissue following infection and participate in the immune response. Specifically, interleukin-17-producing NKT17 and gamma delta T cells play a major role in the infection, with NKT17 cells being preferentially located in lung tissue prior to infection and interacting with CD103(+) dendritic cells. These studies demonstrate the importance of specific cellular interactions and functional subsets of innate-like T cells in protecting against lung infection.
Review
Immunology
Arno Belpaire, Nanja van Geel, Reinhart Speeckaert
Summary: This review summarizes the current evidence regarding the cellular plasticity of Th17 cells in inflammatory skin disorders, highlighting the importance of certain pathogenic Th17 cell subsets in Th1-mediated autoimmunity. These cell subsets are resistant to conventional immunosuppressants, and a deeper understanding of this phenomenon may lead to better insights into the pathogenesis of various skin diseases and the discovery of potential new treatment targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yunyan Sun, Bing Wang, Qianwen Hu, Haixiao Zhang, Xun Lai, Tier Wang, Chunxiao Zhao, Jiali Wang, Xi Zhang, Qing Niu, Baolin He, Erlie Jiang, Mingxia Shi, Xiaoming Feng, Yuechen Luo
Summary: Adipose tissue CD11c(+) myeloid cell is an independent risk factor for obesity and metabolic disorders. In this study, it was found that liver kinase B1 (Lkb1) plays a role in CD11c(+) cell-mediated immune responses in diet-induced obesity. Loss of Lkb1 in CD11c(+) cells leads to obesity resistance but lower glucose tolerance, accompanied by immune abnormalities. The imbalance of IL-17A and IFN-gamma is observed in fat T cells and CD11c(-) macrophages, contributing to the resistance to weight gain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Daniela Andrea Paira, Silene Silvera-Ruiz, Andrea Tissera, Rosa Isabel Molina, Jose Javier Olmedo, Virginia Elena Rivero, Ruben Dario Motrich
Summary: The study suggests that inflammatory cytokines IFN-γ, IL-17A, and IL-1β can individually impair human sperm motility and decrease viability, leading to increased apoptosis. On the other hand, IL-8 does not have a significant impact on sperm.
Article
Immunology
Kaveh Abdi, Karen Laky, Mehrnoosh Abshari, Elizabeth M. Hill, Larry Lantz, Nevil J. Singh, Eric O. Long
Summary: It has been found that NK cells produce IFN-gamma before the production of IL-12 by DCs in the early stage of immune response. Toll-like Receptor 4 (TLR4) on DCs and soluble factors produced by LPS-activated DCs play important roles in IFN-gamma production by NK cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Seema Patel, Heidi R. Tucker, Himanshu Gogoi, Samira Mansouri, Lei Jin
Summary: The cGAS-STING pathway collaborates with the MyD88 pathway in monocytes to promote late-stage lung IFN gamma production during pulmonary pneumococcal infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Microbiology
Marco Rinaldo Oggioni, Uwe Koedel
Summary: Researchers have found a link between impaired glymphatic system functionality and neurological sequelae caused by Streptococcus pneumoniae meningitis. This study provides an important initial step in evaluating the potential impact of glymphatic system functionality on disease severity and sequelae in meningitis.
Article
Infectious Diseases
Clara Ines Agudelo, Carlos Castaneda-Orjuela, Maria Cristina de Cunto Brandileone, Gabriela Echaniz-Aviles, Samanta Cristine Grassi Almeida, Maria Noemi Carnalla-Barajas, Mabel Regueira, Sofia Fossati, Pedro Alarcon, Pamela Araya, Carolina Duarte, Jacqueline Sanchez, Mirna Novas, Gilda Torano-Peraza, Misladys Rodriguez-Ortega, Gustavo Chamorro-Cortesi, Anibal Kawabata, Gabriela Garcia-Gabarrot, Teresa Camou, Enza Spadola, Daisy Payares, Ana Lucia Andrade, Jose Luis Di Fabio, Elizabeth Castaneda
Summary: A multicentre, retrospective observational study in eight Latin American and Caribbean countries assessed the direct effect of pneumococcal conjugate vaccines (PCVs) on the distribution of pneumococcal serotypes causing invasive pneumococcal disease in children younger than 5 years. The study found a significant decrease in the percentage of vaccine serotypes in PCV countries after PCV introduction.
LANCET INFECTIOUS DISEASES
(2021)
Article
Immunology
Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, Lelia Delamarre, Ira Mellman
Summary: Lipid-formulated RNA vaccines can cause systemic inflammatory responses in humans, which were not predicted in preclinical studies. The IL-1 pathway plays a key role in triggering vaccine-induced inflammation, but this effect is dampened in mice.
Review
Biochemistry & Molecular Biology
Adeline Peignier, Dane Parker
Summary: This review discusses recent literature that provides new insights into the mechanisms of how type I IFN signaling exerts its effects on the outcome of infection from the host's point of view. The identified mechanisms have been wide and varied between pathogens.
TRENDS IN MICROBIOLOGY
(2021)
Article
Dermatology
Pawit Phadungsaksawasdi, Toshiharu Fujiyama, Kazuo Kurihara, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura
Summary: In human psoriasis, PD-1 expressing CD8(+) CD103(+) T cells in the skin are associated with disease severity and histopathology, indicating a potential pathogenic subset that may play a role in psoriasis pathogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Health Care Sciences & Services
Xiaozhen Lai, Brian Wahl, Wenzhou Yu, Tingting Xu, Haijun Zhang, Cristina Garcia, Ying Qin, Yan Guo, Zundong Yin, Maria Deloria Knoll, Hai Fang
Summary: The study estimated childhood mortality and morbidity attributable to pneumococcus and Hib in China from 2010 to 2017. It found that while there was a decrease in deaths and cases, the burden still varied significantly by region and province.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Allergy
Claire Barbieux, Mathilde Bonnet des Claustres, Matthias Fahrner, Evgeniya Petrova, Lam C. Tsoi, Olivier Gouin, Florent Leturcq, Pascale Nicaise-Roland, Christine Bole, Vivien Beziat, Emmanuelle Bourrat, Oliver Schilling, Johann E. Gudjonsson, Alain Hovnanian
Summary: This study comprehensively characterizes the skin, immune cells, and allergic phenotypes of Netherton syndrome through multiple molecular profiling methods. The results reveal abnormal epidermal proliferation and differentiation, as well as IL-17/IL-36 signatures in both NS-ILC and NS-SE. Distinct molecular features are found between nonlesion and lesion skin of each disease subtype. Serum cytokine profiling and immunophenotyping show different allergic responses in NS-ILC and NS-SE patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Virology
Ayelen Toro, Sofia Lage-Vickers, Juan Bizzotto, Felipe Vilicich, Agustina Sabater, Gaston Pascual, Sabrina Ledesma-Bazan, Pablo Sanchis, Maria Sol Ruiz, Ana Paula Arevalo, Jorge L. Porfido, Mercedes Abbate, Rocio Seniuk, Estefania Labanca, Nicolas Anselmino, Nora M. Navone, Daniel F. Alonso, Elba Vazquez, Martina Crispo, Javier Cotignola, Geraldine Gueron
Summary: This study demonstrates the important role of IFN-gamma and ISGs in the response to SARS-CoV-2 infection, suggesting their potential as adjuvant immunotherapy for COVID-19 patients. The analysis showed increased expression of IFN-gamma-associated pathways and ISGs in COVID-19-positive patients, which correlated with viral load and STAT1/JAK2 expression.
Article
Biology
Isabelle J. Marie, Lara Brambilla, Doua Azzouz, Ze Chen, Gisele Baracho, Azlann Arnett, Haiyan S. Li, Weiguo Liu, Luisa Cimmino, Pratip Chattopadhyay, Gregg Silverman, Stephanie S. Watowich, Bernard Khor, David E. Levy
Summary: In the absence of tonic interferon (IFN) signaling, mice developed inflammatory diseases spontaneously, including myeloid hyperplasia and inflammatory bowel disease. The dysbiosis in gut bacteria triggered expansion of TH17 cells and loss of splenic Treg cells, which were prevented by reducing bacterial load with antibiotics and blocking IL17 signaling. This study highlights the crucial role of tonic IFNs in regulating gut microbial ecology to maintain immune homeostasis and prevent inflammation.
Article
Microbiology
Xue Liu, Jacqueline M. Kimmey, Laura Matarazzo, Vincent de Bakker, Laurye Van Maele, Jean-Claude Sirard, Victor Nizet, Jan-Willem Veening
Summary: The study used an inducible CRISPR interference system for genome-wide fitness testing of Streptococcus pneumoniae, revealing critical bottlenecks and important genes in a murine pneumonia model. Interestingly, the results showed that some genes may have different roles in vivo compared to in vitro.
CELL HOST & MICROBE
(2021)
Article
Immunology
Thomas Belcher, Hana Kammoun, Loic Coutte, Anne-Sophie Debrie, Nathalie Mielcarek, Jean-Claude Sirard, Stephane Cauchi, Camille Locht
Summary: This study demonstrates that the live attenuated vaccine BPZE1 provides protection against an unrelated bacterial pathogen, Streptococcus pneumoniae, in a mouse model of invasive pneumococcal disease. The protection is linked to live vaccination and the role of the innate immune system.
Article
Respiratory System
Isabelle Fleurot, Raquel Lopez-Galvez, Pascal Barbry, Antoine Guillon, Mustapha Si-Tahar, Andrea Bahr, Nikolai Klymiuk, Jean-Claude Sirard, Ignacio Caballero
Summary: This study reveals a defective TLR5 signaling in the airway epithelium of cystic fibrosis (CF) patients, leading to excessive lung inflammation. These findings contribute to a better understanding of the pathogenesis of CF disease and provide potential therapeutic targets.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Immunology
Melanie Bruchard, Mannon Geindreau, Anais Perrichet, Caroline Truntzer, Elise Ballot, Romain Boidot, Cindy Racoeur, Emilie Barsac, Fanny Chalmin, Christophe Hibos, Thomas Baranek, Christophe Paget, Bernhard Ryffel, Cedric Rebe, Catherine Paul, Frederique Vegran, Francois Ghiringhelli
Summary: This study reveals the essential function of type 3 innate lymphoid cells (ILC3s) in recruiting T cells to the tumor microenvironment and enhancing antitumor immune responses.
Article
Microbiology
Adelaide Chesnay, Christophe Paget, Nathalie Heuze-Vourc'h, Thomas Baranek, Guillaume Desoubeaux
Summary: Pneumocystis pneumonia is a severe lung infection that primarily occurs in immunocompromised patients. In order to study diagnosis and treatment strategies, it is important to understand the biology of the Pneumocystis agent and the course of the disease. Animal studies are crucial for researching Pneumocystis pneumonia in the absence of in vitro continuous culture systems. This overview of animal models in the literature highlights the variability in variables studied and provides important information for researchers in choosing experimental parameters.
Article
Biochemistry & Molecular Biology
Antoine Guillon, Deborah Brea-Diakite, Adeline Cezard, Alan Wacquiez, Thomas Baranek, Jerome Bourgeais, Frederic Picou, Virginie Vasseur, Lea Meyer, Christophe Chevalier, Adrien Auvet, Jose M. Carballido, Lydie Nadal Desbarats, Florent Dingli, Andrei Turtoi, Audrey Le Gouellec, Florence Fauvelle, Amelie Donchet, Thibaut Crepin, Pieter S. Hiemstra, Christophe Paget, Damarys Loew, Olivier Herault, Nadia Naffakh, Ronan Le Goffic, Mustapha Si-Tahar
Summary: Research has shown that influenza virus infection causes significant changes in lung metabolism, leading to the accumulation of succinate in respiratory fluids. Succinate exhibits powerful antiviral activity by inhibiting influenza virus replication and reducing metabolic disruptions and inflammatory responses. Administering succinate intranasally to mice reduces viral loads in the lungs and improves survival rates. The antiviral mechanism involves succinylation of viral nucleoproteins, which alters their interactions with viral RNA.
Review
Immunology
Thomas Baranek, Carolina de Amat Herbozo, Thierry Mallevaey, Christophe Paget
Summary: Invariant natural killer T (iNKT) cells are important biomarkers and targets for immunotherapy. Recent studies have revealed the heterogeneity of iNKT cells and challenged our understanding of their development and differentiation. A new model is proposed to explain the classification and differentiation of iNKT cells.
TRENDS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Christophe Paget, Emilie Doz-Deblauwe, Nathalie Winter, Benoit Briard
Summary: The NLRP3 inflammasome is a critical cytosolic protein platform that mediates inflammatory responses and cell death, playing a crucial role in maintaining homeostasis in the body. Neutrophils, in addition to macrophages and dendritic cells, can also assemble inflammasomes, contributing significantly to the immune processes.
Article
Microbiology
Karin Santoni, David Pericat, Leana Gorse, Julien Buyck, Miriam Pinilla, Laure Prouvensier, Salimata Bagayoko, Audrey Hessel, Stephen Adonai Leon-Icaza, Elisabeth Bellard, Serge Mazeres, Emilie Doz-Deblauwe, Nathalie Winter, Christophe Paget, Jean-Philippe Girard, Christine T. N. Pham, Celine Cougoule, Renaud Poincloux, Mohamed Lamkanfi, Emma Lefrancais, Etienne Meunier, Remi Planes
Summary: This study identifies a new pyroptosis-inducing pathogen, Pseudomonas aeruginosa, and demonstrates that neutrophils are not universally resistant to Caspase-1-dependent pyroptosis.
Article
Virology
Francois Briand, Valentin Sencio, Cyril Robil, Severine Heumel, Lucie Deruyter, Arnaud Machelart, Johanna Barthelemy, Gemma Bogard, Eik Hoffmann, Fabrice Infanti, Oliver Domenig, Audrey Chabrat, Virgile Richard, Vincent Prevot, Ruben Nogueiras, Isabelle Wolowczuk, Florence Pinet, Thierry Sulpice, Francois Trottein
Summary: Obese patients with non-alcoholic steatohepatitis (NASH) are at a higher risk of severe forms of COVID-19. This study established a diet-induced obesity and NASH model in golden hamsters to simulate the disease in humans. The findings suggest that obesity and NASH impair disease recovery in SARS-CoV-2-infected hamsters, providing a valuable model for understanding the pathophysiology of COVID-19 and evaluating treatments for severe forms of the disease in obese NASH patients.
News Item
Immunology
Nicholas A. Gherardin, Francois Legoux, Michela Consonni, Christophe Paget
Summary: CD1 molecules and MR1 molecules play crucial roles in T cell surveillance by presenting lipid and small molecule antigens, respectively. The biology of these molecules and the T cells that respond to them were discussed at the 12th International CD1-MR1 Meeting in Gothenburg, Sweden.
Review
Immunology
Melanie Mondeme, Christophe Carnoy, Jean-Claude Sirard, Christelle Faveeuw
Summary: Beta-lactams are widely prescribed antibiotics for bacterial infections, and their direct effect on bacteria has been extensively studied worldwide. In addition to their direct activity against pathogens, beta-lactams also regulate antibacterial immune responses, suggesting a synergy between the drug and the immune system. This review summarizes the current knowledge on how beta-lactams interact with myeloid cells during bacterial infection treatment.
INFECTION AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Vikrant Minhas, Arnau Domenech, Dimitra Synefiaridou, Daniel Straume, Max Brendel, Gonzalo Cebrero, Xue Liu, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Camilo Perez, Nicolas Gisch, Sven Hammerschmidt, Leiv Sigve Havarstein, Jan-Willem Veening
Summary: Competence development in Streptococcus pneumoniae controls genetic transformation, biofilm formation, and virulence. During competence, the genes involved in teichoic acid biosynthesis are essential. LytR and ComM play crucial roles in WTA synthesis and immunity against CbpD. Moreover, key virulence factors PspA and PspC become more surface-exposed at midcell during competence, in a CbpD-dependent manner.
Correction
Immunology
Christophe Paget, Francois Trottein
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Letter
Critical Care Medicine
Youenn Jouan, Thomas Baranek, Mustapha Si-Tahar, Christophe Paget, Antoine Guillon