期刊
JOURNAL OF INFECTIOUS DISEASES
卷 205, 期 6, 页码 1019-1023出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir874
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资金
- National Center for Research Resources of the National Institutes of Health (NIH) [RR17383]
- National Institute of Allergy and Infectious Diseases of the NIH [AI050471, AI052781]
Cryptosporidium hominis and Cryptosporidium parvum, which infect humans equally, are genetically/antigenically almost identical. It remains unclear, however, whether infection with C. hominis protects against C. parvum. Gnotobiotic piglets were used to investigate cross-protection. After >= 3 days of recovery from C. hominis infection, the piglets were completely protected against subsequent challenge with C. hominis but only partially against challenge with C. parvum, as compared with age-matched control animals challenged with either species. In conclusion, C. hominis-specific immunity was sufficient to completely protect against challenge with the same species but insufficient to provide the same level of protection against C. parvum.
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