期刊
JOURNAL OF INFECTIOUS DISEASES
卷 205, 期 9, 页码 1443-1447出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis211
关键词
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资金
- National Institutes of Health (NIH) [1U01-AI068636, 1U01-AI068634, 1U01-AI069471, 1U01-AI069432, 1U01-AI069484, 201IC001, 204IC006]
- NIH
- Pfizer Inc
We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r = 5 20.7; P < .05) with virological response. The strength of peginterferon alfa-2-ainduced IFIG response significantly correlated with declines in HIV load during treatment (r(2) = 0.87, p = .003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.
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