期刊
JOURNAL OF INFECTIOUS DISEASES
卷 203, 期 4, 页码 500-508出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiq076
关键词
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资金
- Protein Sciences
- Vaxinnate
- sanofi pasteur
- Wyeth
- MedImmune
- Centers for Disease Control and Prevention (CDC)
- National Institutes of Health
- PATH through the Gates Foundation
- Vaccine and Treatment Evaluation Units of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health [N01 AI25462]
- Centers for Disease Control and Prevention [1U181P000184-01]
- National Center for Research Resources at the National Institutes of Health [5 K12 RR017697-05]
- National Institute of Allergy and Infectious Diseases at the National Institutes of Health [1K23AI074863-01]
- Vanderbilt Clinical and Translational Science Award [1 UL1 RR024975]
Background. Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient. Methods. During 3 influenza seasons, 2006-2009, community-dwelling adults aged >= 50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment. Results. Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%). Conclusion. Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations.
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