期刊
JOURNAL OF INFECTIOUS DISEASES
卷 203, 期 2, 页码 175-179出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiq025
关键词
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资金
- National Institutes of Health (NIH) [U01-AI070330, ROI CA112021, 1UO1 AI074503, 1R21 AI077081]
- Defense Threat Reduction Agency Medical Biological Defense Research [4.10007_08_RD_B]
Mannose-binding lectin (MBL) targets diverse microorganisms for phagocytosis and complement-mediated lysis by binding specific surface glycans. Although recombinant human MBL (rhMBL) trials have focused on reconstitution therapy, safety studies have identified no barriers to its use at higher levels. Ebola viruses cause fatal hemorrhagic fevers for which no treatment exists and that are feared as potential biothreat agents. We found that mice whose rhMBL serum concentrations were increased >= 7-fold above average human levels survived otherwise. fatal Ebola virus infections and became immune to virus rechallenge. Because Ebola glycoproteins potentially model other glycosylated viruses, rhMBL may offer a novel broad-spectrum antiviral approach.
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