Review
Microbiology
Hongyan Guo, Heather S. Koehler, Richard D. Dix, Edward S. Mocarski
Summary: HSV1 is a common human pathogen that can cause oral and ocular diseases. Host immune mechanisms and cell death pathways play important roles in controlling HSV1 infection, while the virus has evolved strategies to evade host cell death.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Abigail L. Whitford, Corinne A. Clinton, E. B. Lane Kennedy, Sara A. Dochnal, Jon B. Suzich, Anna R. Cliffe
Summary: The cellular protein DLK plays an essential role in the reactivation of herpes simplex virus, and the mechanisms of gene expression during reactivation are distinct from replication.
JOURNAL OF VIROLOGY
(2022)
Article
Infectious Diseases
Qinwei Yu, Chao Han, Lei Pei, Jinsha Huang, Yan Xu, Tao Wang
Summary: Compelling evidence suggests that status epilepticus is a common cause of rhabdomyolysis, but cases of rhabdomyolysis induced by a single seizure accompanied by viral encephalitis are rarely reported. This case highlights the need for careful analysis of rhabdomyolysis cases with unknown causes, minor seizures, and without status epilepticus, and suggests that HSV virus infection may contribute to rhabdomyolysis.
BMC INFECTIOUS DISEASES
(2021)
Review
Immunology
Iara M. M. Backes, David A. A. Leib, Margaret E. E. Ackerman
Summary: The fetal/neonatal period is a critical stage for interventions and also a vulnerable period for viral infections. Maternal transfer of antibodies can reduce the risk of neonatal herpes simplex virus (nHSV) infections. Exploring the combination of antibody-based interventions and antiviral therapy is important for reducing infant mortality and long-term morbidity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Dor Rafael, Enosh Tomer, Oren Kobiler
Summary: Latent infection is a characteristic feature of herpesviruses, where the number of latent viral genomes reactivating per cell is limited and typically only one genome reactivates in each cell.
MICROBIOLOGY SPECTRUM
(2022)
Article
Virology
Tajanna Stinn, Steve Kuntz, Dana Varon, Meei-Li Huang, Stacy Selke, Samuel Njikan, Emily S. Ford, Joan Dragavon, Robert W. Coombs, Christine Johnston, Marta E. Bull
Summary: This study suggests that subclinical HSV shedding in HIV/HSV-coinfected women during ART may sustain HIV tissue reservoirs through antigen exposure or HIV replication. Frequent subclinical HSV DNA shedding was associated with increased HIV DNA tissue concentrations and increased divergence from ancestral sequences, indicating a potential role of immune responses to common coinfections in sustaining HIV tissue reservoirs during suppressive ART.
JOURNAL OF VIROLOGY
(2021)
Review
Nanoscience & Nanotechnology
Oluwafemi Obisesan, Lebogang Katata-Seru, Steven Mufamadi, Hazel Mufhandu
Summary: Nanoparticles encapsulating drugs show better treatment outcomes in HSV and HIV infections, providing sustained drug release to improve therapeutic effect and mitigate the low drug compliance associated with standalone drugs.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Critical Care Medicine
Tanguy Chaumette, Raphael Cinotti, Alice Molle, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E. G. McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cedric Jacqueline, Mickael Vourc'h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Regis Josien, Jose A. Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, Antoine Roquilly
Summary: Brain injury induces immunosuppression, increasing the risk of viral reactivations and impairing neurological recovery. This study found that lung replication of herpesviridae is associated with poor recovery after brain injury, and a specific monocyte signature can predict the neurological outcome at 6 months.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Immunology
John S. Santelli, Ivy S. Chen, Dorean Nabukalu, Torn Lutalo, Esther J. Spindler, Larry W. Chang, Mary Kate Grabowski, Stephanie A. Grilo, Philip Kreniske, Ying Wei, Fred Nalugoda, Susie Hoffman, Mahiet Maw, Soda Chu, Fred M. Ssewamala, William Byansi, Joseph Kagaayi, Maria J. Wawer, Ronald H. Gray, David Serwadda, Fred Makumbi
Summary: The prevalence of orphanhood among adolescents in the Rakai region of Uganda declined significantly after the widespread availability and uptake of HIV combination prevention strategies such as ART and male circumcision. These reductions in orphanhood are promising for the health and social outcomes of young people.
Article
Multidisciplinary Sciences
Moses Ocan, Frances Acheng, Carol Otike, Judith Beinomugisha, David Katete, Celestino Obua
Summary: The study investigated the extent of protective immune response and breakthrough hepatitis B virus infections among adult vaccinated healthcare workers in northern Uganda. The majority of healthcare workers showed protective levels of hepatitis B antibodies and the protective immune response persisted for over ten years.
Article
Immunology
Jingjing Zhang, Xingli Xu, Suqin Duan, Yang Gao, Danjing Ma, Rong Yue, Fengyuan Zeng, Xueqi Li, Ziyan Meng, Xinghang Li, Zhenye Niu, Guorun Jiang, Li Yu, Yun Liao, Dandan Li, Lichun Wang, Heng Zhao, Ying Zhang, Qihan Li
Summary: This study revealed the strategy of how HSV-1 infection of dendritic cells interferes with the immune system, by investigating the impact of virus infection on both innate and adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Kerry J. Laing, Werner J. D. Ouwendijk, Victoria L. Campbell, Christopher L. McClurkan, Shahin Mortazavi, Michael Elder Waters, Maxwell P. Krist, Richard Tu, Nhi Nguyen, Krithi Basu, Congrong Miao, D. Scott Schmid, Christine Johnston, Georges M. G. M. Verjans, David M. Koelle
Summary: This study reveals that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in the rash-involved skin after recovery from zoster, indicating their importance in controlling skin infections.
NATURE COMMUNICATIONS
(2022)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kavitha K. Prabaker, Annabelle de St Maurice, Daniel Z. Uslan, Gorge C. Yen, Shadi Manavi, Hannah K. Gray, Juan R. Caldera, June L. Chan, Omai B. Garner, Shangxin Yang
Summary: A 39-year-old male presented with fatigue, malaise, and rash on his perianal region. PCR testing confirmed coinfection with monkeypox and herpes simplex virus type 2. It is difficult to distinguish between the two viruses based solely on history and examination.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Engineering, Biomedical
Fuyong Xing, Toby C. Cornish, Tell Bennett, Debashis Ghosh, Lin Yang
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2019)
Article
Pathology
Lindsey M. Westbrook, Patrick A. Henn, Toby C. Cornish
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2020)
Review
Pathology
Toby C. Cornish
ADVANCES IN ANATOMIC PATHOLOGY
(2020)
Editorial Material
Gastroenterology & Hepatology
Jennifer M. Kolb, Hiroyuki Aihara, Sachin Wani, Toby C. Cornish, Hazem Hammad
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Medical Laboratory Technology
Larry J. Kricka, Toby C. Cornish, Jason Y. Park
Summary: Through manual and computerized searches, over 300 eponyms were identified in the field of clinical chemistry, with 97 commonly used in PubMed. The journals CCA and CCJ peaked in eponym citations in 1977, followed by a steady decline.
CLINICA CHIMICA ACTA
(2021)
Editorial Material
Medicine, Research & Experimental
Toby C. Cornish
Summary: Artificial intelligence, including deep learning and generative adversarial networks, has shown promising results in automating the analysis of histopathology images. Utilizing GANs, researchers were able to predict survival outcomes in p16-positive oropharyngeal squamous cell carcinoma, highlighting the potential of deep learning in prognostic analysis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher J. Roth, David A. Clunie, David J. Vining, Seth J. Berkowitz, Alejandro Berlin, Jean-Pierre Bissonnette, Shawn D. Clark, Toby C. Cornish, Monief Eid, Cree M. Gaskin, Alexander K. Goel, Genevieve C. Jacobs, David Kwan, Damien M. Luviano, Morgan P. McBee, Kelly Miller, Abdul Moiz Hafiz, Ceferino Obcemea, Anil Parwani, Veronica Rotemberg, Elliot L. Silver, Erik S. Storm, James E. Tcheng, Karen S. Thullner, Les R. Folio
Summary: Medical disciplines capture diagnostic and evidential static image, video clip, and sound multimedia during routine clinical care, but integrating visual communication aids remains technically challenging.
JOURNAL OF DIGITAL IMAGING
(2021)
Editorial Material
Pathology
Toby C. Cornish, David S. McClintock
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Fuyong Xing, Toby C. Cornish, Tellen D. Bennett, Debashis Ghosh
Summary: This study introduces a method for nucleus detection in cross-modality microscopy image data through bidirectional adversarial domain adaptation, extending unsupervised domain adaptation to semi-supervised learning to improve nucleus detection performance.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seth J. Berkowitz, David Kwan, Toby C. Cornish, Elliot L. Silver, Karen S. Thullner, Alex Aisen, Marilyn M. Bui, Shawn D. Clark, David A. Clunie, Monief Eid, Douglas J. Hartman, Kinson Ho, Andrei Leontiev, Damien M. Luviano, Peter E. O'Toole, Anil V. Parwani, Nielsen S. Pereira, Veronica Rotemberg, David J. Vining, Cree M. Gaskin, Christopher J. Roth, Les R. Folio
Summary: Despite advancements in digital image analysis, many healthcare systems lack the ability to connect textual descriptions of image findings with the actual images. International standards for digitizing image acquisition, storage, viewing, and reporting provide a foundation for enhanced reporting. This paper describes the standard-based infrastructure and communications that fulfill clinical requirements and pave the way for interoperable interactive multimedia reporting.
JOURNAL OF DIGITAL IMAGING
(2022)
Article
Biochemical Research Methods
Ashley L. Kiemen, Alicia M. Braxton, Mia P. Grahn, Kyu Sang Han, Jaanvi Mahesh Babu, Rebecca Reichel, Ann C. Jiang, Bridgette Kim, Jocelyn Hsu, Falone Amoa, Sashank Reddy, Seung-Mo Hong, Toby C. Cornish, Elizabeth D. Thompson, Peng Huang, Laura D. Wood, Ralph H. Hruban, Denis Wirtz, Pei-Hsun Wu
Summary: This study introduces a method called CODA for reconstructing three-dimensional microanatomical structures in large tissues using serially sectioned stained sections. The researchers demonstrated the effectiveness of CODA in reconstructing structures in pancreas, skin, lung, and liver tissues. They also applied CODA to analyze the microanatomy of the human pancreas during tumorigenesis.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Fuyong Xing, Toby C. Cornish
Summary: This paper explores a more realistic and challenging scenario for unsupervised domain adaptation in nucleus detection, where target training data is very scarce. The proposed method augments a dual GAN network with a task-specific model and a stochastic, differentiable data augmentation module, achieving competitive or superior performance over fully supervised models on multiple microscopy image datasets.
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION, MICCAI 2022, PT VII
(2022)
Article
Multidisciplinary Sciences
Toby C. Cornish, Larry J. Kricka, Jason Y. Park
Summary: This method allows for rapid searching and characterization of eponyms in any medical specialty, including non-eponymous terms, by modifying an existing Biopython method. By manually collecting eponym lists, creating permutations, and automatically searching PubMed, this method efficiently enables retrieval of eponyms.
Article
Oncology
Xuhong Zhang, Toby C. Cornish, Lin Yang, Tellen D. Bennett, Debashis Ghosh, Fuyong Xing
JCO CLINICAL CANCER INFORMATICS
(2020)
Meeting Abstract
Pathology
Scott Robertson, Toby Cornish