Article
Medicine, Research & Experimental
Guixiang Dai, Alanna Wanek, Taylor Eddens, Paul Volden, Jay K. Kolls
Summary: Recent genomic data suggest that divergence of major surface glycoproteins may play a role in speciation and host range selectivity of Pneumocystis fungus. Humanized mice provide information about human immune responses involved in controlling Pneumocystis infection. Experiments showed that CD34-engrafted huNOG-EXL mice were able to control fungal burdens more effectively and generate fungal-specific IgM.
Review
Multidisciplinary Sciences
Elahe Sasani, Fares Bahrami, Mohammadreza Salehi, Farzad Aala, Ronak Bakhtiari, Alireza Abdollahi, Bahareh Bashardoust, Mahsa Abdorahimi, Sadegh Khodavaisy
Summary: The admitted patients of intensive care units with COVID-19 face the challenges of subsequent infections, including opportunistic fungal infections such as PCP, which can affect illness severity and mortality. PCP can occur in both immunosuppressed and immunocompetent patients who develop immunosuppression during COVID-19 treatment. Low lymphocyte counts and corticosteroid therapy are major risk factors associated with COVID-19 patients with PCP. Diagnosing and treating PCP in COVID-19 patients can be complicated due to overlapping clinical and radiologic characteristics, thus physicians should evaluate high-risk patients comprehensively for PCP prophylaxis.
Article
Microbiology
Elena Charpentier, Catherine Marques, Sandie Menard, Pamela Chauvin, Emilie Guemas, Claire Cottrel, Sophie Cassaing, Judith Fillaux, Alexis Valentin, Nicolas Blanchard, Antoine Berry, Xavier Iriart
Summary: The host lymphocyte response is crucial in Pneumocystis pneumonia pathophysiology. This study found that low B cell count was associated with PCP, while deceased patients had lower Th1 and Tc1 populations, higher Th2 response, and higher effector TCD8. Factors such as Th1/Th2 ratio, CD8 Tc1, effector TCD8, central memory TCD8, NK cells count, and total lymphocyte count were associated with an increased risk of mortality in PCP.
Article
Medicine, General & Internal
Amjad Kanj, Bilal Samhouri, Nadine Abdallah, Omar Chehab, Misbah Baqir
Summary: The study examined host factors in PCP-related hospitalizations, finding that malignancy was the most prevalent factor, followed by HIV. The prevalence of HIV decreased over time, while non-HIV patients showed higher rates of interventions and worse outcomes compared to HIV patients.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Microbiology
Jessica S. Price, Melissa Fallon, Raquel Posso, Matthijs Backx, P. Lewis White
Summary: This study evaluated the clinical performance of the OLM PneumID real-time PCR assay in the diagnosis of PcP and found that it has high sensitivity and specificity. False positive results can be eliminated by applying specific thresholds. Combining it with (1-3)-beta-D-Glucan testing provides high probabilities of PcP diagnosis.
Article
Microbiology
Victor Gerber, Yvon Ruch, Thien-Nga Chamaraux-Tran, Walid Oulehri, Francis Schneider, Veronique Lindner, Valentin Greigert, Julie Denis, Julie Brunet, Francois Danion
Summary: This study found that cases of Pneumocystis jirovecii pneumonia occasionally occur in patients with COVID-19, particularly in elderly individuals with immunodeficiency or diabetes. These co-infections typically have a poor prognosis, leading to severe pneumonia progression and ultimately death.
Review
Microbiology
Elena Charpentier, Sandie Menard, Catherine Marques, Antoine Berry, Xavier Iriart
Summary: This review examines the host's immune response in Pneumocystis pneumonia, discussing the differences in immune reactions and pathophysiology between immunocompetent and immunodeficient hosts.
Article
Rheumatology
Wen-Hsiu Wang, Chien-Chih Lai, Yi-Fan Huang, Tzu-Hao Li, Yen-Po Tsao, Wei-Sheng Chen, Yu-Sheng Chang
Summary: This study evaluated the risk of Pneumocystis jirovecii pneumonia (PJP) infection in patients with systemic lupus erythematosus (SLE) in Taiwan. The results showed that SLE patients have a significantly higher risk of PJP compared to non-SLE controls. Male sex, end-stage renal disease (ESRD), recent use of mycofenolate mofetil (MMF), intravenous steroid pulse therapy, and high dosage of prednisolone or equivalent treatment were identified as risk factors for PJP in SLE patients. However, the use of hydroxychloroquine reduced the risk of PJP. Notably, cyclophosphamide was not associated with PJP infection in this study.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Biology
Ousmane H. Cisse, Liang Ma, John P. Dekker, Pavel P. Khil, Jung-Ho Youn, Jason M. Brenchley, Robert Blair, Bapi Pahar, Magali Chabe, Koen K. A. Van Rompay, Rebekah Keesler, Antti Sukura, Vanessa Hirsch, Geetha Kutty, Yueqin Liu, Li Peng, Jie Chen, Jun Song, Christiane Weissenbacher-Lang, Jie Xu, Nathan S. Upham, Jason E. Stajich, Christina A. Cuomo, Melanie T. Cushion, Joseph A. Kovacs
Summary: By sequencing and comparing the genomes of Pneumocystis species infecting different mammals, researchers gained insights into the molecular basis of host specificity in Pneumocystis.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diego A. Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado
Summary: The Pneumocystis genus is an opportunistic fungal pathogen that primarily infects AIDS patients and individuals with weakened immune systems. This study focuses on characterizing the function of a specific transcription factor called TFIIB from Pneumocystis carinii using a related model organism, Schizosaccharomyces pombe. The results show that P. carinii TFIIB is capable of replacing the essential function of S. pombe TFIIB, indicating a similar transcriptional machinery between the two organisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Tae-Ok Kim, Jae-Kyeong Lee, Yong-Soo Kwon, Yu-Il Kim, Sung-Chul Lim, Min-Seok Kim, Bo Gun Kho, Cheol-Kyu Park, In-Jae Oh, Young-Chul Kim, Ha Young Park, Hong-Joon Shin
Summary: This study compared the clinical characteristics and prognoses between patients with and without immunocompromised conditions who developed Pneumocystis jirovecii pneumonia (PCP). The findings revealed that patients without immunocompromised conditions had higher mortality rates and delayed anti-PCP treatment was associated with increased 90-day mortality.
Review
Infectious Diseases
Lalita Tancharoen, Soranart Muangsomboon, Patsharaporn T. Sarasombath, Nasikarn Angkasekwinai
Summary: This article presents the second reported case of paraspinal mass caused by P. jirovecii infection in an advanced HIV-infected patient. The patient presented with dyspnea and weight loss, and laboratory findings showed pancytopenia. Histopathological examination confirmed the diagnosis of Pneumocystis jirovecii infection. The patient responded well to a combination of trimethoprim-sulfamethoxazole and antiretroviral therapy.
BMC INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Gongmyung Lee, Tai Yeon Koo, Hyung Woo Kim, Dong Ryeol Lee, Dong Won Lee, Jieun Oh, Beom Seok Kim, Myoung Soo Kim, Jaeseok Yang
Summary: Late PJP after kidney transplantation is as common and risky as early PJP, necessitating individualized prophylaxis strategies.
SCIENTIFIC REPORTS
(2022)
Article
Computer Science, Interdisciplinary Applications
Hongqiang Xie, Tongtong Zhang, Weiwei Song, Shoujun Wang, Hongchang Zhu, Rumin Zhang, Weiping Zhang, Yong Yu, Yan Zhao
Summary: The study proposed an image super-resolution reconstruction model based on the SAGAN algorithm, and experimental results showed that this method outperformed other advanced algorithms in terms of quality and accuracy of pneumonia CT images.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Environmental Sciences
Patrizia Danesi, Matteo Petini, Christian Falcaro, Michela Bertola, Elisa Mazzotta, Tommaso Furlanello, Mark Krockenberger, Richard Malik
Summary: Pneumocystis, an atypical fungus found in the pulmonary parenchyma of mammals, including humans and dogs, was detected in the bronchoalveolar lavage fluid of 9% of dogs with respiratory distress and/or chronic cough. This suggests that Pneumocystis might play a role as a co-pathogen in some dogs with lower respiratory disease.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Nicolas Benech, Oana Dumitrescu, Anne Conrad, Marie Balsat, Etienne Paubelle, Sophie Ducastelle-Lepretre, Helene Labussiere-Wallet, Gilles Salles, Sabine Cohen, Sylvain Goutelle, Florence Ader, F. Ader, V. Alcazer, E. Bachy, M. Balsat, F. Barraco, M. Boccard, G. Billaud, C. Chidiac, A. Conrad, S. Ducastelle-Lepretre, O. Dumitrescu, D. Dupont, V. Escuret, T. Ferry, E. Frobert, H. Ghesquieres, M. Heiblig, H. Labussiere-Wallet, M-V. Larcher, F. Laurent, B. Lina, G. Lina, J. Menotti, P. Miailhes, G. Monneret, F. Morfin-Sherpa, E. Paubelle, T. Perpoint, M. Rabodonirina, M. Renault, C. Roure-Sobas, G. Salles, X. Thomas, F. Valour, F. Venet, F. Wallet, M. Wallon
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Infectious Diseases
Damien Dupont, Pauline Tirard-Collet, Florence Persat, Jean Menotti, Emilie Josse, Martine Wallon, Maxime Pichon
Article
Infectious Diseases
Anne-Lise Bienvenu, Pierre Pradat, Claude Guerin, Frederic Aubrun, Jean-Luc Fellahi, Arnaud Friggeri, Celine Guichon, Romain Hernu, Jean Menotti, Celine Monard, Sylvie Paulus, Thomas Rimmele, Vincent Piriou, Christian Chidiac, Laurent Argaud, Gilles Leboucher
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Respiratory System
S. Gazaignes, A. Bergeron, J. Menotti, K. Desseaux, J-M Molina, N. De Castro
REVUE DES MALADIES RESPIRATOIRES
(2020)
Article
Medical Laboratory Technology
Emilie Frealle, Stephane Valot, Renaud Piarroux, Jean Menotti, Laurence Lachaud, Florence Persat, Arezki Izri, Odile Villard, Helene Yera, Eric Dannaoui, Florent Morio, Sandrine Houze
ANNALES DE BIOLOGIE CLINIQUE
(2020)
Article
Infectious Diseases
Damien Dupont, Jean Menotti, Jean Turc, Charline Miossec, Florent Wallet, Jean-Christophe Richard, Laurent Argaud, Sylvie Paulus, Martine Wallon, Florence Ader, Florence Persat
Article
Microbiology
Damien Costa, Romy Razakandrainibe, Stephane Valot, Margot Vannier, Marc Sautour, Louise Basmaciyan, Gilles Gargala, Venceslas Viller, Denis Lemeteil, Jean-Jacques Ballet, Frederic Dalle, Loic Favennec
Article
Microbiology
Romy Razakandrainibe, Celia Merat, Nathalie Kapel, Marc Sautour, Karine Guyot, Gilles Gargala, Jean-Jacques Ballet, Patrice Le Pape, Frederic Dalle, Loic Favennec
Summary: The coproantigen ELISA test shows high sensitivity and specificity for routine diagnosis of Cryptosporidium spp., indicating its potential usefulness for large-scale epidemiological studies of cryptosporidiosis.
Article
Infectious Diseases
Sarah Soueges, Claire Triffault-Fillit, Sandrine Roux, Helene Labussiere-Wallet, David Lebeaux, Oana Dumitrescu, Isabelle Morelec, Elisabeth Hodille, Florence Ader
Summary: Successful adjunctive use of liposomal nebulized amikacin and tedizolid in a recipient of allogeneic hematopoietic stem cell transplantation infected with Nocardia nova complex presented multiple complications to conventional therapeutic options.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Immunology
Clement Dumond, Florence Aulagnon, Isabelle Etienne, Anne-Elisabeth Heng, Marie-Elisabeth Bougnoux, Loic Favennec, Nassim Kamar, Xavier Iriart, Bruno Pereira, Mathias Buchler, Guillaume Desoubeaux, Hannah Kaminski, Florian Lussac-Sorton, Gilles Gargala, Dany Anglicheau, Philippe Poirier, Anne Scemla, Cyril Garrouste
Summary: Microsporidiosis is an emerging opportunistic infection in renal transplantation recipients, predominantly manifesting as diarrhea and acute renal injury. Treatment involves reducing immunosuppression and administering drugs such as fumagillin, with a high overall clinical remission rate.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Immunology
Jerome Dumortier, Sylvie Radenne, Nassim Kamar, Filomena Conti, Armand Abergel, Audrey Coilly, Claire Francoz, Pauline Houssel-Debry, Claire Vanlemmens, Noemie Laverdure, Christophe Duvoux, Xavier Iriart, Marc Thellier, Adela Angoulvant, Nicolas Argy, Brice Autier, Anne-Pauline Bellanger, Francoise Botterel, Cyril Garrouste, Meja Rabodonirina, Philippe Poirier
Summary: Microsporidiosis is a rare infection after liver transplantation that can lead to severe complications like dehydration and renal failure. Treatment includes changes in immunosuppressive therapy and specific therapy against microsporidiosis. It is important to systematically screen for microsporidiosis in cases of persistent diarrhea after ruling out common infectious causes.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Infectious Diseases
Loic Simon, Tanguy Demeautis, Damien Dupont, Rolf Kramer, Heloise Garnier, Isabelle Durieu, Agathe Senechal, Philippe Reix, Sebastien Couraud, Gilles Devouassoux, Bruno Lina, Meja Rabodonirina, Martine Wallon, Eric Dannaoui, Florence Persat, Jean Menotti
Summary: The prevalence of azole resistance in Aspergillus fumigatus isolates in Lyon was found to be 2.1%, with four isolates exhibiting resistance. Significant induction of expression of the cyp51 genes and two genes encoding efflux transporters was observed, indicating a diversity of resistance mechanisms.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Biochemistry & Molecular Biology
Caroline De Witte, El Moukhtar Aliouat, Cerina Chhuon, Ida Chiara Guerrera, Christine Pierrot, Jamal Khalife
Summary: In this study, the researchers investigated the interactions of protein phosphatase 1 (PP1c) in Plasmodium berghei, a malaria parasite, during both asexual and sexual stages. They identified a variety of proteins that interact with PP1c and found that these interactions play important roles in the parasite's life cycle. Additionally, they discovered potential therapeutic targets that could be used to develop alternative treatment strategies for malaria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Anne-Lise Bienvenu, Pierre Pradat, Alexandra Plesa, Vincent Leclerc, Vincent Piriou, Jean-Luc Fellahi, Laurent Argaud, Thomas Rimmele, Jean Menotti, Frederic Aubrun, Jean-Christophe Richard, Marie-Claude Gagnieu, Francois Parant, Christian Chidiac, Gilles Leboucher, Michel Tod, Sylvain Goutelle
Summary: Therapeutic drug monitoring is crucial for voriconazole to ensure optimal drug exposure in critically ill patients due to the large variability. Factors associated with trough voriconazole concentrations and the impact on adverse effects were studied in a multi-center cohort, showing an association between high SOFA scores, increased voriconazole concentrations, and adverse effects in critically ill patients receiving treatment with voriconazole.
Article
Critical Care Medicine
Jean-Pierre Gangneux, Eric Dannaoui, Arnaud Fekkar, Charles-Edouard Luyt, Francoise Botterel, Nicolas De Prost, Jean-Marc Tadie, Florian Reizine, Sandrine Houze, Jean-Francois Timsit, Xavier Iriart, Beatrice Riu-Poulenc, Boualem Sendid, Saad Nseir, Florence Persat, Florent Wallet, Patrice Le Pape, Emmanuel Canet, Ana Novara, Melek Manai, Estelle Cateau, Arnaud W. Thille, Sophie Brun, Yves Cohen, Alexandre Alanio, Bruno Megarbane, Muriel Cornet, Nicolas Terzi, Lionel Lamhaut, Estelle Sabourin, Guillaume Desoubeaux, Stephan Ehrmann, Christophe Hennequin, Guillaume Voiriot, Gilles Nevez, Cecile Aubron, Valerie Letscher-Bru, Ferhat Meziani, Marion Blaize, Julien Mayaux, Antoine Monsel, Frederique Boquel, Florence Robert-Gangneux, Yves Le Tulzo, Philippe Seguin, Helene Guegan, Brice Autier, Matthieu Lesouhaitier, Romain Pelletier, Sorya Belaz, Christine Bonnal, Antoine Berry, Jordan Leroy, Nadine Francois, Jean-Christophe Richard, Sylvie Paulus, Laurent Argaud, Damien Dupont, Jean Menotti, Florent Morio, Marie Soulie, Carole Schwebel, Cecile Garnaud, Juliette Guitard, Solene Le Gal, Dorothee Quinio, Jeff Morcet, Bruno Laviolle, Jean-Ralph Zahar, Marie-Elisabeth Bougnoux
Summary: This study demonstrates a high prevalence of invasive pulmonary aspergillosis and candidemia in mechanically ventilated patients with severe COVID-19, and a high mortality associated with pr/pb CAPA. These findings highlight the importance of active surveillance for fungal pathogens in patients with severe COVID-19.
LANCET RESPIRATORY MEDICINE
(2022)
