Article
Microbiology
Mingze Cao, Weiwei Wang, Liwei Zhang, Guanhui Liu, Xuzheng Zhou, Bing Li, Yuxiang Shi, Zhen Zhu, Jiyu Zhang
Summary: This study investigated fluoroquinolone resistance and molecular characteristics of S. dysenteriae 1 isolated from calves. The study identified new sequence types ST228 and ST229, with 76.32% of isolates showing fluoroquinolone resistance and multidrug resistance. Continuous surveillance is necessary to control the increasing emergence of multidrug-resistant isolates.
Article
Multidisciplinary Sciences
Moti Iflah, Eias Kassem, Uri Rubinstein, Sophy Goren, Moshe Ephros, Dani Cohen, Khitam Muhsen
Summary: This study found that convulsions in children with AGE were associated with age, Shigella infection, rotavirus infection, body temperature, and high blood glucose levels.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Claire P. Mattison, Laura E. Calderwood, Zachary A. Marsh, Mary E. Wikswo, Neha Balachandran, Anita K. Kambhampati, Michelle E. Gleason, Hannah Lawinger, Sara A. Mirza
Summary: Acute gastroenteritis outbreaks are common in schools and childcare facilities in the United States, with norovirus and Shigella spp. being the main causative agents transmitted through person-to-person contact. The study also found that school outbreaks have higher case numbers but shorter duration compared to childcare outbreaks.
Article
Microbiology
Domonkos Svab, Linda Falgenhauer, Balazs Horvath, Gergely Maroti, Jane Falgenhauer, Trinad Chakraborty, Istvan Toth
Summary: Shigella dysenteriae are significant agents of bacillary dysentery. The Stx toxin is the key virulence factor of SD1 strains. The genomic analysis revealed uniformity among SD1 genomes and the existence of PT-I and PT-II subgroups of the Stx prophage.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Environmental Sciences
Hessamaddin Sohrabi, Mir Reza Majidi, Karim Asadpour-Zeynali, Alireza Khataee, Mahsa Dastborhan, Ahad Mokhtarzadeh
Summary: A gene detection platform was developed to detect Shigella dysenteriae in human plasma samples, incorporating biochar, MoS2 nanosheets, and Au nanoparticles. The platform demonstrated high selectivity and sensitivity, with LOD and LOQ values calculated under optimal conditions. The method also showed good repeatability and could be easily reused for subsequent detection assays, highlighting its potential for practical applications in genetic screening.
Article
Agriculture, Dairy & Animal Science
Xiuli Liang, Pengtao Wang, Kaiqi Lian, Fangfang Han, Yajie Tang, Shouming Zhang, Wenju Zhang
Summary: This study used 16S rRNA gene sequencing to compare the microbial phylum and genus of piglet's enteric microorganism in different experimental groups, and predict the metabolic function of the microbial flora. TGEV infection could cause an imbalance of intestinal microbes in piglets, but with the addition of APB-13, this problem can be alleviated, improving the balance of intestinal microorganisms.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Article
Medicine, Research & Experimental
Yadie Xiang, Xianke Zhou, Hong Zhou, Dier Li, Menghua Zhong, Xue Hong, Dongyan Song, Yinyi Long, Xi Zeng, Yudan Chen, Jiayi Zhou, Dongning Liang, Haiyan Fu
Summary: In this study, it was found that Limonin can improve the liver metabolic microenvironment by inhibiting 11 beta-HSD1, thus alleviating cisplatin-induced ALI. This provides new evidence for the potential of Limonin in the treatment of ALI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Dairy & Animal Science
Martin Peter Rydal, Sheeva Bhattarai, Jens Peter Nielsen
Summary: The study showed that severe iron deficiency anemia during gestation had adverse effects on sow and piglet health, resulting in reduced tissue iron stores post-farrowing.
Article
Immunology
Fatema Moni Chowdhury, Chowdhury Rafiqul Ahsan, Nils-Kare Birkeland
Summary: This study evaluated the efficacy of the non-pathogenic strain DM104 as a vaccine candidate against S. dysenteriae type 4 in a mouse model, showing that oral immunization of live DM104 bacteria provided better protective immunity and induced effective humoral and mucosal immune responses.
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2021)
Article
Multidisciplinary Sciences
Mariana Charleaux de Ponte, Vanessa Gerolde Cardoso, Guilherme Lopes Goncalves, Juliana Martins Costa-Pessoa, Maria Oliveira-Souza
Summary: Compared to the sham group, renal ischemia-reperfusion significantly increased plasma creatinine, urea, and albuminuria levels, while decreasing Nphs1 mRNA expression and nephrin and WT1 protein staining. Tubular injury was also observed with increased Havcr1 and Mki67 mRNA expression and reduced megalin staining. This study suggests that early diabetes could exacerbate renal ischemia-reperfusion-induced acute kidney injury by enhancing renal dysfunction, inflammation, and profibrotic responses.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
David Boulate, Myriam Amsallem, Jean-Baptiste Menager, Simon Dang Van, Peter Dorfmuller, Andrew Connolly, Alban Todesco, Benoit Decante, Elie Fadel, Francois Haddad, Olaf Mercier
Summary: The development of acute right heart failure in the context of chronic pulmonary hypertension is associated with poor outcomes. In this study, a method to induce acute right heart failure in a large animal model of chronic pulmonary hypertension was described. The right ventricular function was dynamically assessed using the gold standard pressure-volume loops and echocardiography. The model can be used for comparing treatments and validating non-invasive parameters of right ventricular function in acute right heart failure.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Gastroenterology & Hepatology
Chang-Ju Zhu, Wan-Guang Yang, De-Jian Li, Yao-Dong Song, San-Yang Chen, Qiao-Fang Wang, Yan-Na Liu, Yan Zhang, Bo Cheng, Zhong-Wei Wu, Zong-Chao Cui
Summary: The study aimed to investigate the role of Cal in SAP-ALI and its underlying mechanism. Results showed that Cal can protect mice against L-arg-induced SAP and associated ALI by attenuating local and systemic neutrophil infiltration and inflammatory response via inhibition of HMGB1 and the NF-kappa B signaling pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Urology & Nephrology
Daniel E. Leisman, Tiago D. Fernandes, Vanesa Bijol, Mabel N. Abraham, Jake R. Lehman, Matthew D. Taylor, Christine Capone, Omar Yaipan, Rinaldo Bellomo, Clifford S. Deutschman
Summary: The study found that sepsis reduces the expression of renal angiotensin II receptors, leading to changes in kidney blood flow and creatinine levels. Both mouse models and clinical observations suggest that angiotensin II prevents these functional changes, while AT1R blockade exacerbates them.
KIDNEY INTERNATIONAL
(2021)
Article
Microbiology
Mario Meza-Segura, James R. Birtley, Ana Maldonado-Contreras, Christian Mueller, Karl J. Simin, Lawrence J. Stern, Beth A. McCormick
Summary: Shigella spp. are highly adapted pathogens that cause bacillary dysentery by disrupting the intestinal epithelial barrier, with SepA releasing a neutrophil chemoattractant that promotes Shigella invasion.
Article
Agriculture, Dairy & Animal Science
Aimei Liu, Yaqin Yang, Jingchao Guo, Yan Gao, Qinghua Wu, Ling Zhao, Lv-hui Sun, Xu Wang
Summary: Deoxynivalenol (DON) is a contaminant in animal feed that can cause liver damage and growth inhibition. This study found that cytochrome P450 (CYP450) enzymes and DNA methylation are related to DON-induced liver injury. Decreasing the expression of CYP450 enzymes can counteract the hepatotoxic effect of DON.