Article
Virology
Helmi Suominen, Nelli Suominen, Kari Syrjaenen, Tim Waterboer, Seija Grenman, Stina Syrjaenen, Karolina Louvanto
Summary: This study found that a second pregnancy does not have a significant impact on HPV antibody levels, but it may influence serological outcomes, especially in ongoing second pregnancies.
Article
Immunology
Nelli T. Suominen, Tiina H. Luukkaala, Claudie Laprise, Marjut A. Haataja, Seija E. Grenman, Stina M. Syrjaenen, Karolina Louvanto
Summary: This study aimed to determine whether vertical human papillomavirus (HPV) transmission occurs from parents to their offspring before or during birth. The study included 321 mothers, 134 fathers, and their 321 newborn offspring. The results showed statistically significant genotype-specific HPV concordance between mother-newborn and father-newborn pairs, suggestive for vertical HPV transmission, but transmission from the father to the newborn remains uncertain.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Ping Gong, Bingwei Shi, Xing Cong, Liu Yang, Chunxiang Gong, Yilan Zhou, Xiaohong Li, Juan Wang
Summary: Human papillomavirus (HPV) infection is the primary cause of cervical cancer, and the prevalence of HPV genotypes in Changzhou has been previously reported. However, the distribution of multiple HPV infections and their roles in cervical injuries have not been thoroughly investigated. In this study, we assessed the prevalence of multiple HPV infections in Changzhou and analyzed whether these infections were associated with abnormalities in E6/E7 mRNA, liquid-based cytology, and cervical histopathology. Our findings indicate that multiple HPV infections containing the top five prevalent HPVs are closely linked to cervical disease progression and should be closely monitored for preventive strategies in Changzhou.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Infectious Diseases
Qinli Luo, Xianghua Zeng, Hanyi Luo, Ling Pan, Ying Huang, Haiyan Zhang, Na Han
Summary: This study found a stronger association between multiple HPV infections and high-grade and low-grade squamous intraepithelial lesions compared to single infections. Specific combinations of HPV types may synergistically affect the risk of HSIL and LSIL.
BMC INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Magdalena R. Vaenesbranden, Johanna Wiik, Katrine Sjoborg, Anne Cathrine Staff, Karin C. Lodrup Carlsen, Guttorm Haugen, Gunilla Hedlin, Katarina Hilde, Bjorn Nordlund, Camilla F. Nystrand, Anbjorg Rangberg, Eva Maria Rehbinder, Knut Rudi, Corina Silvia Rueegg, Yvonne Sandberg, Sigrid Sjelmo, Havard O. Skjerven, Cilla Soderhall, Riyas Vettukattil, Christine M. Jonassen
Summary: This study aimed to identify HPV prevalence and persistence rates in pregnant women, as well as risk factors for infection. The results showed higher HPV prevalence at mid-gestation compared to delivery, with low viral load associated with clearance of HPV infections at delivery. Factors like short pre-conception relationships and alcohol intake during pregnancy increased HPV infection risk.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biology
Vural Yilmaz, Panayiota Louca, Louiza Potamiti, Mihalis Panayiotidis, Katerina Strati
Summary: This study successfully generated an in vivo lineage-tracing model to track papillomavirus-harboring cells and their progeny. By observing MmuPV1-treated tissues, increased proliferation dynamics and decreased MHC-I cell surface expression were found, which may have implications in tissue regenerative capacity and virus clearance. This model provides a novel tool to study the biology of MmuPV1 host-pathogen interactions.
Article
Oncology
Annika Antonsson, Marjorie M. A. de Souza, Benedict J. Panizza, David C. Whiteman
Summary: Oropharyngeal cancer is increasingly caused by HPV, possibly due to changing sexual behavior. Sexual intercourse elicits a stronger immune response to HPV compared to oral sex, potentially leading to a weaker immune response in individuals who have their oral sex debut before or at the same time as sexual intercourse, increasing their risk of developing persistent oral HPV infection and oropharyngeal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Otorhinolaryngology
Barbara Kofler, Andreas Widschwendter, Benedikt Hofauer, Carina Gatt, Sophie Fabel, Anke Leichtle, Alexandra Ciresa-Koenig, Jozsef Dudas, Wegene Borena
Summary: This study investigated the relationship between genital HPV infection and undetected oropharyngeal HPV infection. The results showed a low rate of oropharyngeal HPV infection in the study population, with 2/142 (1.4%) women testing positive for a low-risk HPV genotype. In the genital brush test, 54/142 (38%) women tested positive for HPV, of which 41/142 (29%) were positive for a high-risk HPV genotype.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Annika Antonsson, Marjorie de Souza, Zoe C. Wood, Angela Carroll, Kim Van, Lachlan Paterson, Nirmala Pandeya, David C. Whiteman
Summary: Oral infection with HPV is likely to contribute to the increasing incidence of oropharyngeal squamous cell carcinoma, and is associated with sexual behaviors. New oral infections with HPV in the sample were not rare, with most infections being cleared but not universally, suggesting a reservoir of infection may predispose to oropharyngeal carcinogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Infectious Diseases
Agnieszka Denecke, Thomas Iftner, Angelika Iftner, Sebastian Riedle, Marion Ocak, Alexander Luyten, Isak Ueye, Kuebra Tunc, Karl Ulrich Petry
Summary: The study conducted long-term surveillance on young women in the Wolfsburg HPV epidemiological study (WOLVES) and found that an increase in vaccination coverage was associated with a decreased prevalence of genital warts. The quadrivalent vaccine had a protective effect on genital HPV 6 infection and an almost fully protective effect on the development of genital warts in the youngest population.
BMC INFECTIOUS DISEASES
(2021)
Article
Virology
Moonsik Kim, Nora Jee-Young Park, Ji Yun Jeong, Ji Young Park
Summary: Multiple HPV infections are associated with high-grade SIL and persistent HPV infection compared to single HPV infection, with distinct clinicopathologic characteristics. Close follow up and reporting of multiple HPV infection is warranted.
Article
Immunology
Abbey B. Berenson, Jacqueline M. Hirth, Mihyun Chang
Summary: The study found variations in penile HPV infection prevalence among US males by race/ethnicity and age, with Black males and older age groups exhibiting higher prevalence. Even after controlling for confounders, certain populations still showed significantly elevated HPV infection prevalence.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Bac Nguyen Hoai, Thang Nguyen Cao, Lan Anh Luong Thi, Minh Nam Nguyen, Hong-Quan Duong, Van Thai Than
Summary: The study investigated the prevalence and genotypes of HPVs in Vietnamese male patients hospitalized with sexually transmitted infection symptoms between 2016 and 2020, finding a high prevalence and diversity of HPV infections. It is recommended to include HPV vaccination into the national vaccination program for public health and cancer prevention.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Cintia Munoz-Quiles, Monica Lopez-Lacort, Javier Diez-Domingo, Vallivana Rodrigo-Casares, Alejandro Orrico-Sanchez
Summary: This study aimed to assess the effectiveness of HPV vaccines in preventing genital warts in women. The results showed that a complete schedule of the quadrivalent HPV vaccine was 74% effective in reducing genital warts. The study also suggested indirect protection for unvaccinated and HPV2v vaccinated girls.
Article
Multidisciplinary Sciences
Ming Zhao, Dan Zhou, Min Zhang, Peipei Kang, Meimei Cui, Liling Zhu, Limei Luo
Summary: This study aimed to estimate the genotype distribution of persistent HPV infection in females worldwide, and provide a scientific basis for the prevention strategies of CC and the development of HPV vaccines.
Review
Oncology
Matti Lehtinen, Ville N. Pimenoff, Belinda Nedjai, Karolina Louvanto, Lisanne Verhoef, Danielle A. M. Heideman, Mariam El-Zein, Martin Widschwendter, Joakim Dillner
Summary: This article is based on a recent scientific session that discussed the risk assessment of cervical cancer in the post-vaccination era. The study highlighted the impact of decreasing prevalence of vaccine-targeted high-risk HPV types on the triage methods for cervical intraepithelial neoplasia (CIN)/squamous intraepithelial lesion (SIL). The research emphasized the importance of evaluating new triage modalities in vaccinated women with CIN/SIL associated with nonvaccine HPV types.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Public, Environmental & Occupational Health
Suvi Rintala, Kristina R. Dahlstrom, Eduardo L. Franco, Karolina Louvanto
Summary: The goal of cancer screening guidelines is to provide evidence-based recommendations for cancer prevention. Various organizations have conflicting recommendations, but current guidelines suggest colorectal cancer screening with fecal occult blood test or fecal immunochemical test, cervical cancer screening with Pap-test, HPV-test, or co-testing, and breast cancer screening with mammography. Guidelines differ in terms of age to start and end screening and testing frequency. Constant review of screening guidelines is important to evaluate new screening tests.
PREVENTIVE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Hanna K. Laine, Tim Waterboer, Kari Syrjanen, Seija Grenman, Karolina Louvanto, Stina Syrjanen
Summary: This study analyzed the seroprevalence and antibody levels of BKPyV and JCPyV in 327 pregnant women and their 132 spouses in Finland. The results showed that BKPyV and JCPyV infections were common in married couples, with slightly higher prevalence in women and stable antibody levels.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Virology
Tina Dalianis, Christian von Buchwald, Anders Nasman, Stina Syrjanen
Article
Immunology
Hanna K. Laine, Tim Waterboer, Kari Syrjaenen, Seija Grenman, Karolina Louvanto, Stina Syrjaenen
Summary: This study aimed to investigate the association between BK (BKPyV) and/or JC (JCPyV) polyomavirus serology and HPV in Finnish women. The results showed no significant association between BKPyV or JCPyV seropositivity and HPV seropositivity, HPV DNA positivity, HPV16 persistence, Pap smear grade, or development of CIN.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Niina Kuusisto, Jussi Hirvonen, Auli Suominen, Stina Syrjanen, Sisko Huumonen, Pekka Vallittu, Ilpo Kinnunen
Summary: The study assessed the frequency and location of artifacts in cone beam computed tomography (CBCT) images used to confirm chronic rhinosinusitis (CRS). It was found that large dental fillings or crowns, as well as endodontic fillings, were the main origins of the artifacts. The presence of artifacts might lead to difficulties in diagnosing apical periodontitis (AP) and could also affect the diagnosis of CRS.
Article
Immunology
Nelli T. Suominen, Tiina H. Luukkaala, Claudie Laprise, Marjut A. Haataja, Seija E. Grenman, Stina M. Syrjaenen, Karolina Louvanto
Summary: This study aimed to determine whether vertical human papillomavirus (HPV) transmission occurs from parents to their offspring before or during birth. The study included 321 mothers, 134 fathers, and their 321 newborn offspring. The results showed statistically significant genotype-specific HPV concordance between mother-newborn and father-newborn pairs, suggestive for vertical HPV transmission, but transmission from the father to the newborn remains uncertain.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Helmi Suominen, Nelli Suominen, Kari Syrjaenen, Tim Waterboer, Seija Grenman, Stina Syrjaenen, Karolina Louvanto
Summary: This study found that a second pregnancy does not have a significant impact on HPV antibody levels, but it may influence serological outcomes, especially in ongoing second pregnancies.
Article
Medicine, General & Internal
Laura Bergqvist, Annu Heinonen, Xavier Carcopino, Charles Redman, Karoliina Aro, Mari Kiviharju, Seppo Virtanen, Pirjo-Liisa Omar, Laura Kotaniemi-Talonen, Karolina Louvanto, Pekka Nieminen, Ilkka Kalliala
Summary: This study aimed to evaluate whether electrical impedance spectroscopy (EIS) as an adjunctive technology improves the performance of colposcopy. The results showed that colposcopy with EIS had higher sensitivity but lower specificity to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+). However, the prevalence rates of CIN2+ were not consistently higher in the EIS cohort, indicating the need for further research on the effectiveness of EIS.
Article
Genetics & Heredity
Vivian Reinhold, Stina Syrjanen, Minna Kankuri-Tammilehto
Summary: This study reports a severe case of oligodontia in a female patient with the EDA gene variant c.742-2A>G. The results strongly suggest that this variant is pathogenic and the oligodontia in the patient is exceptionally severe. Early identification of this variant is crucial for planning adequate treatment and follow-up.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Pediatrics
Hanna K. Laine, Tim Waterboer, Kari Syrjanen, Seija Grenman, Karolina Louvanto, Stina Syrjanen
Summary: BK (BKPyV) and JC (JCPyV) polyomaviruses are common in infants, with high correlation of antibody levels between mother-infant pairs. The correlation differs between father-child pairs and may be related to predisposition to allergies.
Article
Biochemistry & Molecular Biology
Nelli T. Suominen, Michel Roger, Marie-Claude Faucher, Kari J. Syrjaenen, Seija E. Grenman, Stina M. Syrjaenen, Karolina Louvanto
Summary: This study evaluated the importance of human leukocyte antigen (HLA)-G alleles in father-to-child human papillomavirus (HPV) transmission during the perinatal period. The results showed that HLA-G allele concordance was associated with the father's urethral and child's oral high-risk HPV concordance at birth. In addition, HLA-G allele concordance increased the risk of father's oral and child's postpartum oral any- and high-risk HPV concordance.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Microbiology
Ville N. Pimenoff, Penelope Gray, Karolina Louvanto, Tiina Eriksson, Camilla Lagheden, Anna Soderlund-Strand, Joakim Dillner, Matti Lehtinen
Summary: The long-term effect of HPV vaccination on non-targeted HPVs is not well understood. An 8-year follow-up study found that gender-neutral vaccination communities showed increased HPV diversity 4 to 8 years post-vaccination, despite the clearance of targeted HPVs. This may impact future cervical cancer screening programs but not the WHO's mission to eliminate cervical cancer.
CELL HOST & MICROBE
(2023)